LDLRAP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1905581Biological processpositive regulation of low-density lipoprotein particle clearance
GO_0031623Biological processreceptor internalization
GO_0006898Biological processreceptor-mediated endocytosis
GO_0008203Biological processcholesterol metabolic process
GO_0090205Biological processpositive regulation of cholesterol metabolic process
GO_0043393Biological processregulation of protein binding
GO_0048260Biological processpositive regulation of receptor-mediated endocytosis
GO_0071345Biological processcellular response to cytokine stimulus
GO_0034383Biological processlow-density lipoprotein particle clearance
GO_0090118Biological processreceptor-mediated endocytosis involved in cholesterol transport
GO_1905602Biological processpositive regulation of receptor-mediated endocytosis involved in cholesterol transport
GO_0042982Biological processamyloid precursor protein metabolic process
GO_1903076Biological processregulation of protein localization to plasma membrane
GO_1904707Biological processpositive regulation of vascular associated smooth muscle cell proliferation
GO_0030301Biological processcholesterol transport
GO_0042632Biological processcholesterol homeostasis
GO_0005886Cellular componentplasma membrane
GO_0055037Cellular componentrecycling endosome
GO_0005769Cellular componentearly endosome
GO_0005883Cellular componentneurofilament
GO_0009898Cellular componentcytoplasmic side of plasma membrane
GO_0030669Cellular componentclathrin-coated endocytic vesicle membrane
GO_0009925Cellular componentbasal plasma membrane
GO_0005829Cellular componentcytosol
GO_0030424Cellular componentaxon
GO_0035612Molecular functionAP-2 adaptor complex binding
GO_0001540Molecular functionamyloid-beta binding
GO_0005546Molecular functionphosphatidylinositol-4,5-bisphosphate binding
GO_0050750Molecular functionlow-density lipoprotein particle receptor binding
GO_0035591Molecular functionsignaling adaptor activity
GO_0030159Molecular functionsignaling receptor complex adaptor activity
GO_0035615Molecular functionclathrin adaptor activity
GO_0030276Molecular functionclathrin binding
GO_0035650Molecular functionAP-1 adaptor complex binding
GO_0005515Molecular functionprotein binding
GO_0001784Molecular functionphosphotyrosine residue binding

IV. Literature review

[source]
Gene nameLDLRAP1
Protein nameLow density lipoprotein receptor adapter protein 1 (Autosomal recessive hypercholesterolemia protein)
SynonymsARH
DescriptionFUNCTION: Adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). May be required for LDL binding and internalization but not for receptor clustering in coated pits. May facilitate the endocytosis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits. May also be involved in the internalization of other LDLR family members. Binds to phosphoinositides, which regulate clathrin bud assembly at the cell surface. Required for trafficking of LRP2 to the endocytic recycling compartment which is necessary for LRP2 proteolysis, releasing a tail fragment which translocates to the nucleus and mediates transcriptional repression (By similarity). .

AccessionsENST00000374338.5
Q5SW96