LCLAT1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006654Biological processphosphatidic acid biosynthetic process
GO_0036149Biological processphosphatidylinositol acyl-chain remodeling
GO_0035965Biological processcardiolipin acyl-chain remodeling
GO_0016024Biological processCDP-diacylglycerol biosynthetic process
GO_0012505Cellular componentendomembrane system
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0003841Molecular function1-acylglycerol-3-phosphate O-acyltransferase activity
GO_0008374Molecular functionO-acyltransferase activity
GO_0016746Molecular functionacyltransferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameLCLAT1
Protein nameLysocardiolipin acyltransferase 1
Lysocardiolipin acyltransferase 1 (EC 2.3.1.-) (1-acylglycerol-3-phosphate O-acyltransferase 8) (1-AGP acyltransferase 8) (1-AGPAT 8) (EC 2.3.1.51) (Acyl-CoA:lysocardiolipin acyltransferase 1)
SynonymsAGPAT8
LYCAT
ALCAT1
UNQ1849/PRO3579
DescriptionFUNCTION: Exhibits acyl-CoA:lysocardiolipin acyltransferase (ALCAT) activity; catalyzes the reacylation of lyso-cardiolipin to cardiolipin (CL), a key step in CL remodeling (By similarity). Recognizes both monolysocardiolipin and dilysocardiolipin as substrates with a preference for linoleoyl-CoA and oleoyl-CoA as acyl donors (By similarity). Also exhibits 1-acyl-sn-glycerol-3-phosphate acyltransferase activity (AGPAT) activity; converts 1-acyl-sn-glycerol-3- phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3- phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone . Possesses both lysophosphatidylinositol acyltransferase (LPIAT) and lysophosphatidylglycerol acyltransferase (LPGAT) activities . Required for establishment of the hematopoietic and endothelial lineages (By similarity). .

AccessionsENST00000379509.8 [Q6UWP7-3]
C9JXY8
ENST00000466477.5
C9JA02
Q6UWP7
C9J5S5
ENST00000476038.5
ENST00000488144.5
ENST00000497423.1
C9K0C3
C9J6F4
ENST00000465200.5
C9JUV9
F8WEY2
C9JMW2
ENST00000309052.8 [Q6UWP7-1]
ENST00000478015.5
ENST00000319406.8 [Q6UWP7-2]
ENST00000465538.5
ENST00000476535.1