I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| mast cell | 15 studies | 24% ± 6% | |
| plasma cell | 6 studies | 25% ± 7% | |
| natural killer cell | 3 studies | 16% ± 0% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| mast cell | 15 studies | 24% ± 6% | |
| plasma cell | 6 studies | 25% ± 7% | |
| natural killer cell | 3 studies | 16% ± 0% |
Insufficient scRNA-seq data for expression of LAX1 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| lung | 100% | 181.17 | 576 / 578 | 88% | 5.81 | 1016 / 1155 |
| stomach | 95% | 91.80 | 340 / 359 | 70% | 3.60 | 199 / 286 |
| esophagus | 88% | 75.18 | 1272 / 1445 | 63% | 3.14 | 115 / 183 |
| breast | 86% | 61.83 | 396 / 459 | 65% | 3.33 | 722 / 1118 |
| bladder | 100% | 103.19 | 21 / 21 | 46% | 1.53 | 230 / 504 |
| intestine | 84% | 208.66 | 809 / 966 | 60% | 2.35 | 314 / 527 |
| uterus | 85% | 45.02 | 145 / 170 | 42% | 1.47 | 195 / 459 |
| skin | 62% | 41.08 | 1130 / 1809 | 51% | 3.36 | 240 / 472 |
| prostate | 82% | 55.62 | 202 / 245 | 26% | 0.58 | 129 / 502 |
| kidney | 45% | 40.22 | 40 / 89 | 55% | 1.89 | 499 / 901 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 26.62 | 29 / 29 |
| spleen | 100% | 848.19 | 241 / 241 | 0% | 0 | 0 / 0 |
| peripheral blood | 98% | 486.12 | 908 / 929 | 0% | 0 | 0 / 0 |
| thymus | 57% | 67.81 | 369 / 653 | 39% | 2.35 | 238 / 605 |
| adipose | 95% | 82.08 | 1142 / 1204 | 0% | 0 | 0 / 0 |
| liver | 65% | 23.65 | 148 / 226 | 17% | 0.50 | 70 / 406 |
| tonsil | 0% | 0 | 0 / 0 | 78% | 6.62 | 35 / 45 |
| pancreas | 16% | 4.77 | 51 / 328 | 55% | 2.25 | 98 / 178 |
| ovary | 19% | 6.98 | 35 / 180 | 28% | 0.81 | 120 / 430 |
| blood vessel | 41% | 21.56 | 545 / 1335 | 0% | 0 | 0 / 0 |
| adrenal gland | 34% | 12.34 | 89 / 258 | 4% | 0.07 | 9 / 230 |
| heart | 17% | 6.14 | 145 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 9% | 0.29 | 7 / 80 |
| brain | 3% | 0.71 | 68 / 2642 | 6% | 0.13 | 39 / 705 |
| muscle | 5% | 1.35 | 40 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0046649 | Biological process | lymphocyte activation |
| GO_0006955 | Biological process | immune response |
| GO_0002250 | Biological process | adaptive immune response |
| GO_0050868 | Biological process | negative regulation of T cell activation |
| GO_0050851 | Biological process | antigen receptor-mediated signaling pathway |
| GO_0035556 | Biological process | intracellular signal transduction |
| GO_0042113 | Biological process | B cell activation |
| GO_0043409 | Biological process | negative regulation of MAPK cascade |
| GO_0045121 | Cellular component | membrane raft |
| GO_0005829 | Cellular component | cytosol |
| GO_0005794 | Cellular component | Golgi apparatus |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0016020 | Cellular component | membrane |
| GO_0042169 | Molecular function | SH2 domain binding |
| GO_0019901 | Molecular function | protein kinase binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | LAX1 |
| Protein name | Lymphocyte transmembrane adapter 1 (Linker for activation of X cells) (Membrane-associated adapter protein LAX) |
| Synonyms | LAX |
| Description | FUNCTION: Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and BCR (B-cell antigen receptor)-mediated signaling in B-cells. . |
| Accessions | Q8IWV1 ENST00000442561.7 [Q8IWV1-1] ENST00000367217.5 [Q8IWV1-3] |
