Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| GABAergic neuron | 6 studies | 33% ± 18% | |
| astrocyte | 5 studies | 25% ± 10% | |
| oligodendrocyte | 5 studies | 25% ± 8% | |
| glutamatergic neuron | 4 studies | 39% ± 20% | |
| oligodendrocyte precursor cell | 4 studies | 32% ± 11% | |
| interneuron | 4 studies | 39% ± 23% | |
| GABAergic interneuron | 3 studies | 24% ± 9% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 5 studies | 35% ± 7% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 99% | 2124.91 | 2613 / 2642 | 65% | 1.28 | 460 / 705 |
| ovary | 100% | 1963.36 | 180 / 180 | 53% | 1.11 | 230 / 430 |
| esophagus | 100% | 1128.79 | 1444 / 1445 | 52% | 1.06 | 95 / 183 |
| stomach | 99% | 770.70 | 354 / 359 | 36% | 0.77 | 104 / 286 |
| uterus | 100% | 1679.06 | 170 / 170 | 31% | 0.53 | 144 / 459 |
| lung | 98% | 803.27 | 568 / 578 | 31% | 0.56 | 361 / 1155 |
| kidney | 100% | 1254.01 | 89 / 89 | 28% | 0.49 | 255 / 901 |
| adrenal gland | 100% | 1131.36 | 258 / 258 | 28% | 0.43 | 64 / 230 |
| intestine | 100% | 1210.12 | 966 / 966 | 27% | 0.49 | 143 / 527 |
| bladder | 100% | 1210.81 | 21 / 21 | 26% | 0.60 | 133 / 504 |
| thymus | 100% | 1970.18 | 653 / 653 | 26% | 0.37 | 156 / 605 |
| breast | 100% | 1097.53 | 458 / 459 | 19% | 0.34 | 212 / 1118 |
| pancreas | 95% | 491.34 | 311 / 328 | 22% | 0.37 | 40 / 178 |
| prostate | 100% | 1722.05 | 245 / 245 | 14% | 0.20 | 70 / 502 |
| spleen | 100% | 1268.76 | 241 / 241 | 0% | 0 | 0 / 0 |
| skin | 84% | 700.61 | 1521 / 1809 | 15% | 0.24 | 73 / 472 |
| blood vessel | 99% | 1152.00 | 1327 / 1335 | 0% | 0 | 0 / 0 |
| muscle | 98% | 645.03 | 783 / 803 | 0% | 0 | 0 / 0 |
| adipose | 97% | 660.98 | 1168 / 1204 | 0% | 0 | 0 / 0 |
| heart | 91% | 561.57 | 781 / 861 | 0% | 0 | 0 / 0 |
| liver | 57% | 204.71 | 128 / 226 | 4% | 0.06 | 17 / 406 |
| peripheral blood | 39% | 222.18 | 365 / 929 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 20% | 0.32 | 9 / 45 |
| lymph node | 0% | 0 | 0 / 0 | 10% | 0.12 | 3 / 29 |
| eye | 0% | 0 | 0 / 0 | 9% | 0.13 | 7 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0006325 | Biological process | chromatin organization |
| GO_0030097 | Biological process | hemopoiesis |
| GO_0045652 | Biological process | regulation of megakaryocyte differentiation |
| GO_0031507 | Biological process | heterochromatin formation |
| GO_0045892 | Biological process | negative regulation of DNA-templated transcription |
| GO_0051726 | Biological process | regulation of cell cycle |
| GO_0007088 | Biological process | regulation of mitotic nuclear division |
| GO_0005730 | Cellular component | nucleolus |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0061793 | Cellular component | chromatin lock complex |
| GO_0000793 | Cellular component | condensed chromosome |
| GO_0000785 | Cellular component | chromatin |
| GO_0005634 | Cellular component | nucleus |
| GO_0035064 | Molecular function | methylated histone binding |
| GO_0042393 | Molecular function | histone binding |
| GO_0003682 | Molecular function | chromatin binding |
| GO_0042802 | Molecular function | identical protein binding |
| GO_0032093 | Molecular function | SAM domain binding |
| GO_0008270 | Molecular function | zinc ion binding |
| GO_0031491 | Molecular function | nucleosome binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | L3MBTL1 |
| Protein name | L3MBTL histone methyl-lysine binding protein 1 Lethal(3)malignant brain tumor-like protein 1 (H-l(3)mbt) (H-l(3)mbt protein) (L(3)mbt-like) (L(3)mbt protein homolog) (L3MBTL1) |
| Synonyms | KIAA0681 L3MBTL L3MBT |
| Description | FUNCTION: Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, therey acting as a 'reader' of a network of post-translational modifications. PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/H1-4 at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription. Recognizes and binds p53/TP53 monomethylated at 'Lys-382', leading to repress p53/TP53-target genes. Also recognizes and binds RB1/RB monomethylated at 'Lys-860'. Participates in the ETV6-mediated repression. Probably plays a role in cell proliferation. Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis. . |
| Accessions | ENST00000649698.1 A0A3B3ISV7 ENST00000373135.8 [Q9Y468-1] ENST00000648774.1 ENST00000373134.5 A0A3B3ISP5 A0A3F2YNZ1 A0A3B3ISB7 ENST00000439769.2 ENST00000647860.1 A0A3B3ITG5 H0Y7I2 ENST00000649501.1 A0A3B3IS65 ENST00000648570.1 B0QYN4 A0A3B3ISK5 ENST00000649917.1 B0QYN5 ENST00000648421.1 ENST00000650484.1 ENST00000650349.1 ENST00000427442.8 [Q9Y468-5] A0A994J4Z1 Q9Y468 ENST00000473981.2 A0A0A0MRR4 A0A3B3IUA3 ENST00000422861.3 [Q9Y468-4] A0A3B3ISS0 ENST00000445228.6 A0A3B3IT75 ENST00000704961.1 ENST00000434666.6 ENST00000649084.1 ENST00000418998.7 |
