KRT5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045109Biological processintermediate filament organization
GO_0032880Biological processregulation of protein localization
GO_0009612Biological processresponse to mechanical stimulus
GO_0031424Biological processkeratinization
GO_0008544Biological processepidermis development
GO_0030334Biological processregulation of cell migration
GO_0045107Biological processintermediate filament polymerization
GO_0005882Cellular componentintermediate filament
GO_0070062Cellular componentextracellular exosome
GO_0005829Cellular componentcytosol
GO_0045095Cellular componentkeratin filament
GO_0016020Cellular componentmembrane
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0005200Molecular functionstructural constituent of cytoskeleton
GO_0097110Molecular functionscaffold protein binding
GO_0030280Molecular functionstructural constituent of skin epidermis
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameKRT5
Protein nameKeratin, type II cytoskeletal 5 (58 kDa cytokeratin) (Cytokeratin-5) (CK-5) (Keratin-5) (K5) (Type-II keratin Kb5)
Keratin
Keratin, type II cytoskeletal 5 (Cytokeratin-5) (Keratin-5) (Type-II keratin Kb5)
Keratin 5
Synonyms
DescriptionFUNCTION: Required for the formation of keratin intermediate filaments in the basal epidermis and maintenance of the skin barrier in response to mechanical stress (By similarity). Regulates the recruitment of Langerhans cells to the epidermis, potentially by modulation of the abundance of macrophage chemotactic cytokines, macrophage inflammatory cytokines and CTNND1 localization in keratinocytes (By similarity). .

AccessionsF8VV57
ENST00000551275.1
ENST00000548409.5
ENST00000549420.1
ENST00000252242.9
ENST00000546577.1
F8VU69
H0YI76
ENST00000551188.5
H0YIN9
F8W0C6
Q9UEK9
P13647