Name | Number of supported studies | Average coverage | |
---|---|---|---|
basal cell | 22 studies | 64% ± 20% | |
plasmacytoid dendritic cell | 12 studies | 21% ± 6% | |
epithelial cell | 5 studies | 51% ± 13% | |
keratinocyte | 5 studies | 65% ± 15% | |
hillock cell | 3 studies | 68% ± 35% | |
secretory cell | 3 studies | 28% ± 10% | |
myoepithelial cell | 3 studies | 66% ± 30% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 38% | 228543.15 | 556 / 1445 | 61% | 3103.83 | 111 / 183 |
tonsil | 0% | 0 | 0 / 0 | 98% | 11412.72 | 44 / 45 |
skin | 72% | 296256.02 | 1304 / 1809 | 11% | 319.19 | 51 / 472 |
breast | 45% | 23671.30 | 206 / 459 | 17% | 170.32 | 192 / 1118 |
uterus | 1% | 3341.83 | 2 / 170 | 60% | 4486.94 | 277 / 459 |
prostate | 27% | 10081.90 | 67 / 245 | 16% | 63.49 | 78 / 502 |
lung | 0% | 50.49 | 1 / 578 | 37% | 1919.22 | 433 / 1155 |
bladder | 0% | 0 | 0 / 21 | 31% | 1350.79 | 156 / 504 |
thymus | 0% | 51.04 | 1 / 653 | 15% | 338.25 | 90 / 605 |
pancreas | 0% | 0 | 0 / 328 | 10% | 219.59 | 17 / 178 |
ovary | 0% | 0 | 0 / 180 | 4% | 18.36 | 17 / 430 |
lymph node | 0% | 0 | 0 / 0 | 3% | 9.43 | 1 / 29 |
intestine | 0% | 0 | 0 / 966 | 3% | 73.02 | 18 / 527 |
adipose | 1% | 479.77 | 7 / 1204 | 0% | 0 | 0 / 0 |
stomach | 1% | 371.67 | 2 / 359 | 0% | 0 | 0 / 286 |
muscle | 0% | 70.74 | 2 / 803 | 0% | 0 | 0 / 0 |
kidney | 0% | 0 | 0 / 89 | 0% | 0.38 | 1 / 901 |
blood vessel | 0% | 190.56 | 1 / 1335 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
adrenal gland | 0% | 0 | 0 / 258 | 0% | 0 | 0 / 230 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
brain | 0% | 0 | 0 / 2642 | 0% | 0 | 0 / 705 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
heart | 0% | 0 | 0 / 861 | 0% | 0 | 0 / 0 |
liver | 0% | 0 | 0 / 226 | 0% | 0 | 0 / 406 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
peripheral blood | 0% | 0 | 0 / 929 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spleen | 0% | 0 | 0 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0045109 | Biological process | intermediate filament organization |
GO_0032880 | Biological process | regulation of protein localization |
GO_0009612 | Biological process | response to mechanical stimulus |
GO_0031424 | Biological process | keratinization |
GO_0008544 | Biological process | epidermis development |
GO_0030334 | Biological process | regulation of cell migration |
GO_0045107 | Biological process | intermediate filament polymerization |
GO_0005882 | Cellular component | intermediate filament |
GO_0070062 | Cellular component | extracellular exosome |
GO_0005829 | Cellular component | cytosol |
GO_0045095 | Cellular component | keratin filament |
GO_0016020 | Cellular component | membrane |
GO_0005737 | Cellular component | cytoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0005200 | Molecular function | structural constituent of cytoskeleton |
GO_0097110 | Molecular function | scaffold protein binding |
GO_0030280 | Molecular function | structural constituent of skin epidermis |
GO_0005515 | Molecular function | protein binding |
Gene name | KRT5 |
Protein name | Keratin, type II cytoskeletal 5 (58 kDa cytokeratin) (Cytokeratin-5) (CK-5) (Keratin-5) (K5) (Type-II keratin Kb5) Keratin Keratin, type II cytoskeletal 5 (Cytokeratin-5) (Keratin-5) (Type-II keratin Kb5) Keratin 5 |
Synonyms | |
Description | FUNCTION: Required for the formation of keratin intermediate filaments in the basal epidermis and maintenance of the skin barrier in response to mechanical stress (By similarity). Regulates the recruitment of Langerhans cells to the epidermis, potentially by modulation of the abundance of macrophage chemotactic cytokines, macrophage inflammatory cytokines and CTNND1 localization in keratinocytes (By similarity). . |
Accessions | F8VV57 ENST00000551275.1 ENST00000548409.5 ENST00000549420.1 ENST00000252242.9 ENST00000546577.1 F8VU69 H0YI76 ENST00000551188.5 H0YIN9 F8W0C6 Q9UEK9 P13647 |