KPNA6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0075506Biological processentry of viral genome into host nucleus through nuclear pore complex via importin
GO_0006366Biological processtranscription by RNA polymerase II
GO_1903902Biological processpositive regulation of viral life cycle
GO_1900017Biological processpositive regulation of cytokine production involved in inflammatory response
GO_0060135Biological processmaternal process involved in female pregnancy
GO_0019079Biological processviral genome replication
GO_0006606Biological processprotein import into nucleus
GO_0006607Biological processNLS-bearing protein import into nucleus
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0043657Cellular componenthost cell
GO_0042564Cellular componentNLS-dependent protein nuclear import complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0016020Cellular componentmembrane
GO_0005634Cellular componentnucleus
GO_0008139Molecular functionnuclear localization sequence binding
GO_0005515Molecular functionprotein binding
GO_0061608Molecular functionnuclear import signal receptor activity

IV. Literature review

[source]
Gene nameKPNA6
Protein nameImportin subunit alpha-7
Alternative protein KPNA6
Importin subunit alpha-7 (Karyopherin subunit alpha-6)
Karyopherin subunit alpha 6
SynonymsIPOA7
DescriptionFUNCTION: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. .

AccessionsQ5TFJ7
L8E7Z7
O60684
ENST00000373625.8
ENST00000471599.5
G1UI19
S4R3E5
ENST00000446515.1