Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 15 studies | 26% ± 8% | |
fibroblast | 10 studies | 20% ± 5% | |
ciliated cell | 8 studies | 25% ± 9% | |
glutamatergic neuron | 7 studies | 42% ± 26% | |
oligodendrocyte | 7 studies | 24% ± 8% | |
epithelial cell | 6 studies | 36% ± 14% | |
basal cell | 6 studies | 24% ± 7% | |
GABAergic neuron | 6 studies | 40% ± 22% | |
macrophage | 6 studies | 24% ± 5% | |
B cell | 5 studies | 20% ± 3% | |
microglial cell | 5 studies | 23% ± 5% | |
myeloid cell | 5 studies | 21% ± 3% | |
adipocyte | 5 studies | 20% ± 4% | |
type I pneumocyte | 5 studies | 20% ± 4% | |
type II pneumocyte | 5 studies | 19% ± 4% | |
astrocyte | 5 studies | 31% ± 7% | |
oligodendrocyte precursor cell | 5 studies | 30% ± 7% | |
goblet cell | 5 studies | 29% ± 14% | |
neuron | 4 studies | 31% ± 12% | |
club cell | 4 studies | 24% ± 10% | |
pericyte | 4 studies | 21% ± 5% | |
smooth muscle cell | 4 studies | 19% ± 2% | |
endothelial cell of lymphatic vessel | 4 studies | 21% ± 4% | |
pancreatic A cell | 3 studies | 46% ± 25% | |
type B pancreatic cell | 3 studies | 46% ± 24% | |
classical monocyte | 3 studies | 24% ± 5% | |
retinal cone cell | 3 studies | 24% ± 7% | |
lymphocyte | 3 studies | 24% ± 1% | |
muscle cell | 3 studies | 22% ± 5% | |
natural killer cell | 3 studies | 18% ± 3% | |
abnormal cell | 3 studies | 28% ± 5% | |
enteroendocrine cell | 3 studies | 24% ± 5% | |
alveolar macrophage | 3 studies | 20% ± 5% | |
transit amplifying cell | 3 studies | 24% ± 10% | |
plasmacytoid dendritic cell | 3 studies | 23% ± 3% | |
mast cell | 3 studies | 20% ± 0% | |
interneuron | 3 studies | 43% ± 14% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 5864.70 | 1445 / 1445 | 100% | 53.87 | 183 / 183 |
lung | 100% | 5175.01 | 578 / 578 | 100% | 39.42 | 1155 / 1155 |
stomach | 100% | 4039.42 | 359 / 359 | 100% | 34.96 | 286 / 286 |
intestine | 100% | 5069.13 | 966 / 966 | 100% | 31.11 | 526 / 527 |
ovary | 100% | 4354.28 | 180 / 180 | 100% | 42.17 | 429 / 430 |
breast | 100% | 4695.87 | 459 / 459 | 100% | 45.76 | 1115 / 1118 |
prostate | 100% | 4934.25 | 245 / 245 | 99% | 34.95 | 499 / 502 |
skin | 100% | 6211.74 | 1809 / 1809 | 99% | 40.26 | 469 / 472 |
uterus | 100% | 5753.64 | 170 / 170 | 99% | 35.62 | 456 / 459 |
thymus | 100% | 4906.65 | 653 / 653 | 99% | 38.36 | 601 / 605 |
bladder | 100% | 5253.62 | 21 / 21 | 99% | 31.74 | 500 / 504 |
brain | 99% | 3747.12 | 2615 / 2642 | 100% | 32.41 | 705 / 705 |
pancreas | 100% | 2483.10 | 327 / 328 | 99% | 30.44 | 176 / 178 |
kidney | 100% | 3674.65 | 89 / 89 | 98% | 29.07 | 879 / 901 |
adrenal gland | 100% | 4971.83 | 258 / 258 | 92% | 24.11 | 212 / 230 |
liver | 100% | 2743.86 | 226 / 226 | 90% | 15.34 | 366 / 406 |
adipose | 100% | 4824.67 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 5637.70 | 1335 / 1335 | 0% | 0 | 0 / 0 |
muscle | 100% | 7569.23 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 4006.90 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 39.61 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 16.46 | 1 / 1 |
heart | 98% | 4569.61 | 842 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 97% | 3188.76 | 900 / 929 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 97% | 22.89 | 28 / 29 |
eye | 0% | 0 | 0 / 0 | 94% | 17.95 | 75 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0075506 | Biological process | entry of viral genome into host nucleus through nuclear pore complex via importin |
GO_0006366 | Biological process | transcription by RNA polymerase II |
GO_1903902 | Biological process | positive regulation of viral life cycle |
GO_1900017 | Biological process | positive regulation of cytokine production involved in inflammatory response |
GO_0060135 | Biological process | maternal process involved in female pregnancy |
GO_0019079 | Biological process | viral genome replication |
GO_0006606 | Biological process | protein import into nucleus |
GO_0006607 | Biological process | NLS-bearing protein import into nucleus |
GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
GO_0043657 | Cellular component | host cell |
GO_0042564 | Cellular component | NLS-dependent protein nuclear import complex |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005829 | Cellular component | cytosol |
GO_0016020 | Cellular component | membrane |
GO_0005634 | Cellular component | nucleus |
GO_0008139 | Molecular function | nuclear localization sequence binding |
GO_0005515 | Molecular function | protein binding |
GO_0061608 | Molecular function | nuclear import signal receptor activity |
Gene name | KPNA6 |
Protein name | Importin subunit alpha-7 Alternative protein KPNA6 Importin subunit alpha-7 (Karyopherin subunit alpha-6) Karyopherin subunit alpha 6 |
Synonyms | IPOA7 |
Description | FUNCTION: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. . |
Accessions | Q5TFJ7 L8E7Z7 O60684 ENST00000373625.8 ENST00000471599.5 G1UI19 S4R3E5 ENST00000446515.1 |