KPNA2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0075506Biological processentry of viral genome into host nucleus through nuclear pore complex via importin
GO_1903902Biological processpositive regulation of viral life cycle
GO_0032481Biological processpositive regulation of type I interferon production
GO_0000018Biological processregulation of DNA recombination
GO_0006259Biological processDNA metabolic process
GO_0006606Biological processprotein import into nucleus
GO_0006607Biological processNLS-bearing protein import into nucleus
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005654Cellular componentnucleoplasm
GO_0000139Cellular componentGolgi membrane
GO_0042564Cellular componentNLS-dependent protein nuclear import complex
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0043657Cellular componenthost cell
GO_0031965Cellular componentnuclear membrane
GO_0005634Cellular componentnucleus
GO_0008139Molecular functionnuclear localization sequence binding
GO_0061608Molecular functionnuclear import signal receptor activity
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding
GO_0042826Molecular functionhistone deacetylase binding

IV. Literature review

[source]
Gene nameKPNA2
Protein nameImportin subunit alpha
Importin subunit alpha-1
Karyopherin subunit alpha 2
Importin subunit alpha-1 (Karyopherin subunit alpha-2) (RAG cohort protein 1) (SRP1-alpha)
SynonymsSRP1
RCH1
DescriptionFUNCTION: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

FUNCTION: Functions in nuclear protein import. .

FUNCTION: Functions in nuclear protein import. .

FUNCTION: Functions in nuclear protein import. .

FUNCTION: Functions in nuclear protein import. .

AccessionsENST00000584026.6
ENST00000679078.1
ENST00000579754.2
ENST00000677827.1
ENST00000677086.1
ENST00000537025.6
A0A7I2V487
A0A7I2YQE1
ENST00000584026
Q7Z726
ENST00000583269.5
ENST00000579754
ENST00000678388.1
J3QLL0
ENST00000676857.1
A0A7I2V351
P52292
ENST00000330459.8
J3KS65
A0A7I2V3Z3
J3QL07
ENST00000676594.1