KLHDC10 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0032874Biological processpositive regulation of stress-activated MAPK cascade
GO_0140627Biological processubiquitin-dependent protein catabolic process via the C-end degron rule pathway
GO_0072344Biological processrescue of stalled ribosome
GO_0005654Cellular componentnucleoplasm
GO_0031462Cellular componentCul2-RING ubiquitin ligase complex
GO_0005737Cellular componentcytoplasm
GO_1990756Molecular functionubiquitin-like ligase-substrate adaptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameKLHDC10
Protein nameAlternative protein KLHDC10
Kelch domain-containing protein 10
Kelch domain containing 10
SynonymsKIAA0265
DescriptionFUNCTION: Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation . The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms . The CRL2(KLHDC10) complex specifically recognizes proteins with a proline-glycine (Pro-Gly) or an alanine tail (CAT tail) at the C-terminus, leading to their ubiquitination and degradation . The CRL2(KLHDC10) complex is involved in the ribosome-associated quality control (RQC) pathway, which mediates the extraction of incompletely synthesized nascent chains from stalled ribosomes: CRL2(KLHDC10) acts downstream of NEMF and recognizes CAT tails associated with stalled nascent chains, leading to their ubiquitination and degradation . Participates in the oxidative stress-induced cell death through MAP3K5 activation . Inhibits PPP5C phosphatase activity on MAP3K5 . Acts as a regulator of necroptosis (By similarity). .

AccessionsENST00000335420.10 [Q6PID8-1]
C9JRX2
ENST00000468226.1
ENST00000463413.1
Q6PID8
C9JRT7
L8E8L8
Q96G43