KIDINS220 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0038180Biological processnerve growth factor signaling pathway
GO_0001701Biological processin utero embryonic development
GO_0010976Biological processpositive regulation of neuron projection development
GO_1990090Biological processcellular response to nerve growth factor stimulus
GO_0048813Biological processdendrite morphogenesis
GO_0032991Cellular componentprotein-containing complex
GO_0005829Cellular componentcytosol
GO_0005770Cellular componentlate endosome
GO_0016020Cellular componentmembrane
GO_0030165Molecular functionPDZ domain binding
GO_0019887Molecular functionprotein kinase regulator activity

IV. Literature review

[source]
Gene nameKIDINS220
Protein nameKinase D interacting substrate 220
Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein)
Truncated KIDINS220 isoform h2
Truncated KIDINS220 isoform h3
Kinase D-interacting substrate of 220 kDa
Truncated KIDINS220 isoform h1
SynonymsKIAA1250
ARMS
DescriptionFUNCTION: Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. .

AccessionsENST00000689369.1
A0A8I5KTL1
ENST00000687894.1
ENST00000687912.1
ENST00000473731.5 [Q9ULH0-4]
ENST00000488729.5
ENST00000692419.1
A0A8I5KT58
ENST00000691030.1
A0A8I5QL22
ENST00000686906.1
Q9ULH0
A0A076N408
A0A8I5QJC0
ENST00000638224.1
ENST00000689531.1
A0A8I5KX08
A0A1W2PPY4
A0A1W2PPB7
ENST00000569008.2
A0A8I5KQK7
A0A076NBC8
ENST00000319688.5 [Q9ULH0-3]
A0A8I5KPM9
G1UI41
ENST00000689852.1
F8WAY8
ENST00000496383.5
ENST00000459813.2
H0Y8E4
ENST00000489024.5
A0A076N8A7
E9PH70
ENST00000693432.1
ENST00000685097.1 [Q9ULH0-2]
A0A8I5KTG3
ENST00000256707.8 [Q9ULH0-1]
A0A8I5KZ42
H7C584
ENST00000693394.1