KIAA0586 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0060271Biological processcilium assembly
GO_0007224Biological processsmoothened signaling pathway
GO_0070201Biological processregulation of establishment of protein localization
GO_0005814Cellular componentcentriole
GO_0005813Cellular componentcentrosome
GO_0036064Cellular componentciliary basal body
GO_0001917Cellular componentphotoreceptor inner segment
GO_0005737Cellular componentcytoplasm
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameKIAA0586
Protein nameAlternative protein KIAA0586
KIAA0586
Protein TALPID3
SynonymsTALPID3
DescriptionFUNCTION: Required for ciliogenesis and sonic hedgehog/SHH signaling. Required for the centrosomal recruitment of RAB8A and for the targeting of centriole satellite proteins to centrosomes such as of PCM1. May play a role in early ciliogenesis in the disappearance of centriolar satellites that preceeds ciliary vesicle formation . Involved in regulation of cell intracellular organization. Involved in regulation of cell polarity (By similarity). Required for asymmetrical localization of CEP120 to daughter centrioles (By similarity). .

AccessionsG3V2T5
A0A494C0Z1
A0A494C058
ENST00000651596.1
ENST00000650904.1
ENST00000354386.10 [Q9BVV6-3]
ENST00000555833.5
H0YJF0
A0A494C110
ENST00000423743.7 [Q9BVV6-4]
A0A087WYM5
A0A494C1C3
L0R885
ENST00000652732.1
ENST00000652414.1
ENST00000651937.1
ENST00000619416.4 [Q9BVV6-1]
Q9BVV6
G3V4J0
ENST00000554463.5
A0A494C0M8
ENST00000651852.1
A0A494C133
ENST00000651759.1
ENST00000652326.2
A0A494C075
A0A494C171
ENST00000261244.9 [Q9BVV6-2]
ENST00000619722.5
ENST00000555397.1