Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| endothelial cell | 5 studies | 24% ± 11% | |
| epithelial cell | 4 studies | 33% ± 10% | |
| classical monocyte | 3 studies | 21% ± 3% | |
| ciliated cell | 3 studies | 26% ± 7% | |
| basal cell | 3 studies | 20% ± 4% | |
| astrocyte | 3 studies | 20% ± 3% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 4 studies | 32% ± 14% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| breast | 100% | 7641.22 | 459 / 459 | 100% | 64.96 | 1118 / 1118 |
| esophagus | 100% | 8200.56 | 1445 / 1445 | 100% | 53.90 | 183 / 183 |
| prostate | 100% | 7852.00 | 245 / 245 | 100% | 44.93 | 502 / 502 |
| skin | 100% | 9488.54 | 1809 / 1809 | 100% | 60.04 | 472 / 472 |
| stomach | 100% | 6280.98 | 359 / 359 | 100% | 54.72 | 286 / 286 |
| bladder | 100% | 7977.48 | 21 / 21 | 100% | 51.49 | 503 / 504 |
| uterus | 100% | 11901.52 | 170 / 170 | 100% | 66.94 | 458 / 459 |
| ovary | 100% | 11834.81 | 180 / 180 | 100% | 47.32 | 429 / 430 |
| lung | 100% | 8621.41 | 578 / 578 | 100% | 51.48 | 1152 / 1155 |
| thymus | 100% | 9333.79 | 653 / 653 | 100% | 55.77 | 603 / 605 |
| intestine | 100% | 8073.67 | 966 / 966 | 100% | 55.11 | 525 / 527 |
| adrenal gland | 100% | 8506.76 | 258 / 258 | 100% | 45.30 | 229 / 230 |
| pancreas | 100% | 4526.14 | 328 / 328 | 99% | 46.35 | 176 / 178 |
| kidney | 100% | 5808.96 | 89 / 89 | 98% | 37.59 | 882 / 901 |
| brain | 98% | 5426.52 | 2596 / 2642 | 100% | 52.35 | 702 / 705 |
| liver | 100% | 3986.23 | 226 / 226 | 90% | 23.91 | 365 / 406 |
| adipose | 100% | 6754.77 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 100% | 39.82 | 80 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 53.30 | 29 / 29 |
| muscle | 100% | 8912.32 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 9519.87 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 47.83 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 15.89 | 1 / 1 |
| blood vessel | 100% | 7164.91 | 1334 / 1335 | 0% | 0 | 0 / 0 |
| peripheral blood | 99% | 7072.44 | 916 / 929 | 0% | 0 | 0 / 0 |
| heart | 98% | 4534.63 | 842 / 861 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0006338 | Biological process | chromatin remodeling |
| GO_0009636 | Biological process | response to toxic substance |
| GO_0048511 | Biological process | rhythmic process |
| GO_0045892 | Biological process | negative regulation of DNA-templated transcription |
| GO_0006355 | Biological process | regulation of DNA-templated transcription |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005829 | Cellular component | cytosol |
| GO_0000785 | Cellular component | chromatin |
| GO_0005634 | Cellular component | nucleus |
| GO_0032453 | Molecular function | histone H3K4 demethylase activity |
| GO_0003677 | Molecular function | DNA binding |
| GO_0032452 | Molecular function | histone demethylase activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0008270 | Molecular function | zinc ion binding |
| GO_0034647 | Molecular function | histone H3K4me/H3K4me2/H3K4me3 demethylase activity |
| Gene name | KDM5C |
| Protein name | [histone H3]-trimethyl-L-lysine(4) demethylase (EC 1.14.11.67) Lysine demethylase 5C Alternative protein KDM5C Lysine-specific demethylase 5C (EC 1.14.11.67) (Histone demethylase JARID1C) (Jumonji/ARID domain-containing protein 1C) (Protein SmcX) (Protein Xe169) ([histone H3]-trimethyl-L-lysine(4) demethylase 5C) |
| Synonyms | JARID1C XE169 SMCX DXS1272E |
| Description | FUNCTION: Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code . Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity). . |
| Accessions | ENST00000685423.1 ENST00000429877.5 ENST00000428012.1 A0A8I5QL21 F8WF56 L8E945 A0A8I5KQR8 P41229 ENST00000685641.1 ENST00000452825.7 [P41229-4] ENST00000688699.1 A0A8I5KPH7 ENST00000404049.7 [P41229-5] A0A8I5KYW1 ENST00000375383.7 [P41229-3] ENST00000375379.7 [P41229-2] ENST00000375401.8 [P41229-1] ENST00000693277.1 F8WDK1 ENST00000687695.1 A0A8I5KXH7 ENST00000691505.1 A0A6M4C8G8 A0A8I5KTT1 |
