KDM4B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007420Biological processbrain development
GO_0010468Biological processregulation of gene expression
GO_0006338Biological processchromatin remodeling
GO_0005654Cellular componentnucleoplasm
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0032452Molecular functionhistone demethylase activity
GO_0140684Molecular functionhistone H3K9me2/H3K9me3 demethylase activity
GO_0032454Molecular functionhistone H3K9 demethylase activity
GO_0046872Molecular functionmetal ion binding
GO_0051864Molecular functionhistone H3K36 demethylase activity

IV. Literature review

[source]
Gene nameKDM4B
Protein name[histone H3]-trimethyl-L-lysine(9) demethylase (EC 1.14.11.66)
Lysine demethylase 4B
Lysine-specific demethylase 4B (EC 1.14.11.66) (JmjC domain-containing histone demethylation protein 3B) (Jumonji domain-containing protein 2B) ([histone H3]-trimethyl-L-lysine(9) demethylase 4B)
SynonymsJMJD2B
KIAA0876
JHDM3B
DescriptionFUNCTION: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate . Plays a critical role in the development of the central nervous system (CNS). .

AccessionsF5GX28
ENST00000381759.8 [O94953-2]
ENST00000588361.1
K7ES23
A0A0C4DFL8
ENST00000536461.5
ENST00000611640.4
K7EQ54
O94953
ENST00000588337.5
ENST00000159111.9