Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| B cell | 19 studies | 20% ± 5% | |
| endothelial cell | 12 studies | 32% ± 17% | |
| astrocyte | 11 studies | 26% ± 12% | |
| microglial cell | 9 studies | 33% ± 13% | |
| oligodendrocyte precursor cell | 9 studies | 31% ± 14% | |
| naive B cell | 9 studies | 22% ± 5% | |
| glutamatergic neuron | 8 studies | 37% ± 22% | |
| adipocyte | 8 studies | 27% ± 9% | |
| fibroblast | 8 studies | 25% ± 11% | |
| macrophage | 7 studies | 32% ± 17% | |
| memory B cell | 7 studies | 19% ± 3% | |
| GABAergic neuron | 7 studies | 37% ± 18% | |
| oligodendrocyte | 7 studies | 28% ± 9% | |
| interneuron | 6 studies | 36% ± 20% | |
| retina horizontal cell | 5 studies | 29% ± 14% | |
| retinal cone cell | 5 studies | 29% ± 11% | |
| ciliated cell | 5 studies | 22% ± 6% | |
| amacrine cell | 4 studies | 27% ± 9% | |
| neuron | 4 studies | 38% ± 10% | |
| myeloid cell | 4 studies | 20% ± 6% | |
| epithelial cell | 4 studies | 42% ± 19% | |
| immature B cell | 4 studies | 25% ± 8% | |
| cardiac muscle cell | 4 studies | 25% ± 4% | |
| retinal rod cell | 4 studies | 33% ± 12% | |
| monocyte | 4 studies | 23% ± 6% | |
| smooth muscle cell | 4 studies | 18% ± 3% | |
| classical monocyte | 3 studies | 20% ± 3% | |
| GABAergic interneuron | 3 studies | 26% ± 14% | |
| granule cell | 3 studies | 30% ± 5% | |
| retinal ganglion cell | 3 studies | 21% ± 4% | |
| Mueller cell | 3 studies | 23% ± 6% | |
| hepatocyte | 3 studies | 45% ± 17% | |
| dendritic cell | 3 studies | 22% ± 4% | |
| alveolar macrophage | 3 studies | 22% ± 6% | |
| endothelial cell of lymphatic vessel | 3 studies | 21% ± 4% | |
| pericyte | 3 studies | 23% ± 5% | |
| lymphocyte | 3 studies | 23% ± 3% | |
| basal cell | 3 studies | 39% ± 22% | |
| goblet cell | 3 studies | 42% ± 25% | |
| mucus secreting cell | 3 studies | 22% ± 4% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| prostate | 100% | 8037.38 | 245 / 245 | 100% | 30.03 | 502 / 502 |
| thymus | 100% | 9465.90 | 653 / 653 | 99% | 19.19 | 601 / 605 |
| breast | 100% | 5557.78 | 459 / 459 | 99% | 39.55 | 1110 / 1118 |
| skin | 100% | 5357.20 | 1809 / 1809 | 98% | 11.70 | 463 / 472 |
| pancreas | 100% | 2246.31 | 328 / 328 | 98% | 10.27 | 174 / 178 |
| esophagus | 100% | 4512.48 | 1445 / 1445 | 97% | 11.87 | 178 / 183 |
| kidney | 100% | 2738.34 | 89 / 89 | 97% | 12.60 | 876 / 901 |
| uterus | 100% | 5840.31 | 170 / 170 | 97% | 11.88 | 446 / 459 |
| bladder | 100% | 4001.76 | 21 / 21 | 97% | 11.30 | 489 / 504 |
| brain | 98% | 2968.13 | 2578 / 2642 | 99% | 22.73 | 700 / 705 |
| intestine | 100% | 4062.81 | 966 / 966 | 96% | 9.92 | 508 / 527 |
| adrenal gland | 100% | 5425.20 | 258 / 258 | 95% | 12.76 | 219 / 230 |
| lung | 100% | 3915.44 | 576 / 578 | 95% | 10.44 | 1095 / 1155 |
| stomach | 100% | 3013.13 | 359 / 359 | 94% | 9.36 | 269 / 286 |
| ovary | 100% | 5028.91 | 180 / 180 | 92% | 10.38 | 394 / 430 |
| liver | 100% | 3669.40 | 226 / 226 | 83% | 7.06 | 337 / 406 |
| adipose | 100% | 3578.83 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 17.77 | 29 / 29 |
| muscle | 100% | 5253.02 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 6335.67 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 12.62 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 10.84 | 1 / 1 |
| blood vessel | 100% | 2952.44 | 1333 / 1335 | 0% | 0 | 0 / 0 |
| peripheral blood | 99% | 7837.90 | 917 / 929 | 0% | 0 | 0 / 0 |
| heart | 98% | 2731.75 | 840 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 91% | 7.54 | 73 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0007420 | Biological process | brain development |
| GO_0010468 | Biological process | regulation of gene expression |
| GO_0006338 | Biological process | chromatin remodeling |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0000785 | Cellular component | chromatin |
| GO_0005634 | Cellular component | nucleus |
| GO_0032452 | Molecular function | histone demethylase activity |
| GO_0140684 | Molecular function | histone H3K9me2/H3K9me3 demethylase activity |
| GO_0032454 | Molecular function | histone H3K9 demethylase activity |
| GO_0046872 | Molecular function | metal ion binding |
| GO_0051864 | Molecular function | histone H3K36 demethylase activity |
| Gene name | KDM4B |
| Protein name | [histone H3]-trimethyl-L-lysine(9) demethylase (EC 1.14.11.66) Lysine demethylase 4B Lysine-specific demethylase 4B (EC 1.14.11.66) (JmjC domain-containing histone demethylation protein 3B) (Jumonji domain-containing protein 2B) ([histone H3]-trimethyl-L-lysine(9) demethylase 4B) |
| Synonyms | JMJD2B KIAA0876 JHDM3B |
| Description | FUNCTION: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate . Plays a critical role in the development of the central nervous system (CNS). . |
| Accessions | F5GX28 ENST00000381759.8 [O94953-2] ENST00000588361.1 K7ES23 A0A0C4DFL8 ENST00000536461.5 ENST00000611640.4 K7EQ54 O94953 ENST00000588337.5 ENST00000159111.9 |