Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| classical monocyte | 11 studies | 27% ± 11% | |
| non-classical monocyte | 6 studies | 21% ± 6% | |
| monocyte | 4 studies | 20% ± 3% | |
| epithelial cell | 4 studies | 23% ± 2% | |
| respiratory goblet cell | 3 studies | 24% ± 5% | |
| intestinal crypt stem cell | 3 studies | 22% ± 4% |
Insufficient scRNA-seq data for expression of KCNE3 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| stomach | 96% | 679.77 | 343 / 359 | 97% | 55.57 | 276 / 286 |
| kidney | 100% | 756.11 | 89 / 89 | 85% | 37.52 | 767 / 901 |
| pancreas | 99% | 458.30 | 325 / 328 | 86% | 27.12 | 153 / 178 |
| ovary | 100% | 664.89 | 180 / 180 | 84% | 13.58 | 362 / 430 |
| intestine | 84% | 659.74 | 811 / 966 | 97% | 45.42 | 513 / 527 |
| lung | 99% | 626.67 | 571 / 578 | 77% | 19.72 | 892 / 1155 |
| esophagus | 84% | 193.71 | 1215 / 1445 | 62% | 38.89 | 114 / 183 |
| bladder | 100% | 406.14 | 21 / 21 | 45% | 14.97 | 226 / 504 |
| thymus | 99% | 683.77 | 646 / 653 | 46% | 6.77 | 276 / 605 |
| uterus | 99% | 487.40 | 168 / 170 | 37% | 6.75 | 170 / 459 |
| adrenal gland | 86% | 175.50 | 222 / 258 | 34% | 6.01 | 78 / 230 |
| breast | 97% | 413.83 | 447 / 459 | 18% | 1.27 | 204 / 1118 |
| prostate | 99% | 665.24 | 243 / 245 | 16% | 1.47 | 79 / 502 |
| spleen | 100% | 912.49 | 241 / 241 | 0% | 0 | 0 / 0 |
| adipose | 97% | 397.39 | 1167 / 1204 | 0% | 0 | 0 / 0 |
| peripheral blood | 81% | 2038.58 | 752 / 929 | 0% | 0 | 0 / 0 |
| brain | 54% | 83.95 | 1416 / 2642 | 24% | 2.36 | 171 / 705 |
| heart | 75% | 161.81 | 649 / 861 | 0% | 0 | 0 / 0 |
| liver | 53% | 82.44 | 120 / 226 | 19% | 1.73 | 79 / 406 |
| blood vessel | 51% | 105.47 | 682 / 1335 | 0% | 0 | 0 / 0 |
| skin | 24% | 34.29 | 439 / 1809 | 23% | 1.87 | 108 / 472 |
| lymph node | 0% | 0 | 0 / 0 | 45% | 3.90 | 13 / 29 |
| tonsil | 0% | 0 | 0 / 0 | 24% | 5.01 | 11 / 45 |
| muscle | 3% | 3.12 | 23 / 803 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 1% | 0.07 | 1 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0060307 | Biological process | regulation of ventricular cardiac muscle cell membrane repolarization |
| GO_1903817 | Biological process | negative regulation of voltage-gated potassium channel activity |
| GO_1903765 | Biological process | negative regulation of potassium ion export across plasma membrane |
| GO_1905025 | Biological process | negative regulation of membrane repolarization during ventricular cardiac muscle cell action potential |
| GO_0086011 | Biological process | membrane repolarization during action potential |
| GO_0086005 | Biological process | ventricular cardiac muscle cell action potential |
| GO_0098915 | Biological process | membrane repolarization during ventricular cardiac muscle cell action potential |
| GO_1902260 | Biological process | negative regulation of delayed rectifier potassium channel activity |
| GO_0097623 | Biological process | potassium ion export across plasma membrane |
| GO_0006814 | Biological process | sodium ion transport |
| GO_0086091 | Biological process | regulation of heart rate by cardiac conduction |
| GO_0030644 | Biological process | intracellular chloride ion homeostasis |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0045121 | Cellular component | membrane raft |
| GO_0043204 | Cellular component | perikaryon |
| GO_0032809 | Cellular component | neuronal cell body membrane |
| GO_0030425 | Cellular component | dendrite |
| GO_1990794 | Cellular component | basolateral part of cell |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0031982 | Cellular component | vesicle |
| GO_0008076 | Cellular component | voltage-gated potassium channel complex |
| GO_0005251 | Molecular function | delayed rectifier potassium channel activity |
| GO_1902282 | Molecular function | voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization |
| GO_0015459 | Molecular function | potassium channel regulator activity |
| GO_0044325 | Molecular function | transmembrane transporter binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | KCNE3 |
| Protein name | Cardiac voltage-gated potassium channel accessory subunit isoform 3a (Cardiac voltage-gated potassium channel accessory subunit isoform 3b) (Potassium voltage-gated channel subfamily E regulatory subunit 3) KCNE3 protein (Potassium voltage-gated channel subfamily E member 3) (Potassium voltage-gated channel, Isk-related family, member 3) (cDNA, FLJ92142, Homo sapiens potassium voltage-gated channel, Isk-related family,member 3 (KCNE3), mRNA) Potassium voltage-gated channel subfamily E member 3 (MinK-related peptide 2) (Minimum potassium ion channel-related peptide 2) (Potassium channel subunit beta MiRP2) Potassium voltage-gated channel subfamily E regulatory subunit 3 |
| Synonyms | DKFZp781H21101 hCG_27327 |
| Description | FUNCTION: Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 . Associated with KCNC4/Kv3.4 is proposed to form the subthreshold voltage-gated potassium channel in skeletal muscle and to establish the resting membrane potential (RMP) in muscle cells. Associated with KCNQ1/KCLQT1 may form the intestinal cAMP-stimulated potassium channel involved in chloride secretion that produces a current with nearly instantaneous activation with a linear current-voltage relationship. . |
| Accessions | ENST00000529425.5 ENST00000310128.9 Q9Y6H6 E9PJV9 ENST00000525550.1 ENST00000526855.1 Q6IAE6 E9PN03 Q2N1I1 ENST00000532569.5 E9PJQ7 ENST00000531854.5 |
