JAG1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
pericyte	26 studies	36% ± 19%	Explore
smooth muscle cell	24 studies	33% ± 12%	Explore
endothelial cell	18 studies	29% ± 9%	Explore
basal cell	9 studies	30% ± 14%	Explore
endothelial cell of vascular tree	7 studies	31% ± 9%	Explore
endothelial cell of artery	6 studies	40% ± 11%	Explore
epithelial cell	6 studies	36% ± 15%	Explore
ciliated cell	5 studies	32% ± 24%	Explore
endothelial cell of lymphatic vessel	4 studies	19% ± 3%	Explore
vein endothelial cell	4 studies	30% ± 9%	Explore
fibroblast	4 studies	39% ± 15%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	30% ± 3%	Explore
myofibroblast cell	3 studies	34% ± 21%	Explore
connective tissue cell	3 studies	34% ± 8%	Explore
keratinocyte	3 studies	23% ± 9%	Explore

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of JAG1 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
prostate	100%	8450.33	245 / 245	97%	58.51	485 / 502
esophagus	97%	7953.15	1398 / 1445	99%	122.50	182 / 183
intestine	99%	5710.05	952 / 966	96%	39.86	507 / 527
uterus	100%	9610.52	170 / 170	94%	61.68	433 / 459
breast	100%	9707.33	459 / 459	91%	32.30	1012 / 1118
bladder	100%	8272.71	21 / 21	90%	52.77	452 / 504
thymus	99%	6552.86	649 / 653	89%	29.24	537 / 605
stomach	89%	4116.97	321 / 359	96%	40.82	274 / 286
lung	99%	7282.35	574 / 578	81%	68.88	933 / 1155
pancreas	81%	2404.19	267 / 328	97%	53.29	172 / 178
kidney	83%	3816.54	74 / 89	89%	63.42	801 / 901
ovary	96%	5920.44	172 / 180	66%	17.26	282 / 430
skin	84%	12435.93	1527 / 1809	65%	22.79	308 / 472
brain	22%	583.36	594 / 2642	78%	28.21	551 / 705
adipose	100%	11680.37	1204 / 1204	0%	0	0 / 0
blood vessel	100%	24391.95	1335 / 1335	0%	0	0 / 0
spleen	99%	4936.97	239 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	98%	77.67	44 / 45
adrenal gland	28%	689.24	71 / 258	66%	22.17	151 / 230
heart	93%	3741.99	799 / 861	0%	0	0 / 0
liver	4%	104.14	9 / 226	33%	14.68	136 / 406
muscle	35%	947.14	284 / 803	0%	0	0 / 0
eye	0%	0	0 / 0	28%	5.11	22 / 80
lymph node	0%	0	0 / 0	7%	2.82	2 / 29
peripheral blood	4%	118.73	34 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0030216	Biological process	keratinocyte differentiation
GO_0001525	Biological process	angiogenesis
GO_0001974	Biological process	blood vessel remodeling
GO_0097150	Biological process	neuronal stem cell population maintenance
GO_0030097	Biological process	hemopoiesis
GO_0072017	Biological process	distal tubule development
GO_0007219	Biological process	Notch signaling pathway
GO_0002011	Biological process	morphogenesis of an epithelial sheet
GO_0001709	Biological process	cell fate determination
GO_0045446	Biological process	endothelial cell differentiation
GO_0061444	Biological process	endocardial cushion cell development
GO_0060411	Biological process	cardiac septum morphogenesis
GO_0032495	Biological process	response to muramyl dipeptide
GO_0042491	Biological process	inner ear auditory receptor cell differentiation
GO_0001953	Biological process	negative regulation of cell-matrix adhesion
GO_0045599	Biological process	negative regulation of fat cell differentiation
GO_0003180	Biological process	aortic valve morphogenesis
GO_0061309	Biological process	cardiac neural crest cell development involved in outflow tract morphogenesis
GO_0045669	Biological process	positive regulation of osteoblast differentiation
GO_0045602	Biological process	negative regulation of endothelial cell differentiation
GO_2000241	Biological process	regulation of reproductive process
GO_0002085	Biological process	inhibition of neuroepithelial cell differentiation
GO_0061073	Biological process	ciliary body morphogenesis
GO_0072070	Biological process	loop of Henle development
GO_0022408	Biological process	negative regulation of cell-cell adhesion
GO_0061101	Biological process	neuroendocrine cell differentiation
GO_0045665	Biological process	negative regulation of neuron differentiation
GO_0062043	Biological process	positive regulation of cardiac epithelial to mesenchymal transition
GO_0050678	Biological process	regulation of epithelial cell proliferation
GO_0072006	Biological process	nephron development
GO_0035909	Biological process	aorta morphogenesis
GO_0045445	Biological process	myoblast differentiation
GO_2000737	Biological process	negative regulation of stem cell differentiation
GO_0072015	Biological process	podocyte development
GO_0061156	Biological process	pulmonary artery morphogenesis
GO_0030336	Biological process	negative regulation of cell migration
GO_0003184	Biological process	pulmonary valve morphogenesis
GO_0045639	Biological process	positive regulation of myeloid cell differentiation
GO_0045747	Biological process	positive regulation of Notch signaling pathway
GO_0002456	Biological process	T cell mediated immunity
GO_0007399	Biological process	nervous system development
GO_0042127	Biological process	regulation of cell population proliferation
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0003215	Biological process	cardiac right ventricle morphogenesis
GO_0016324	Cellular component	apical plasma membrane
GO_0005576	Cellular component	extracellular region
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0005912	Cellular component	adherens junction
GO_0060090	Molecular function	molecular adaptor activity
GO_0005543	Molecular function	phospholipid binding
GO_0005112	Molecular function	Notch binding
GO_0005198	Molecular function	structural molecule activity
GO_0008083	Molecular function	growth factor activity
GO_0005509	Molecular function	calcium ion binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	JAG1
Protein name	Protein jagged-1 (Jagged1) (hJ1) (CD antigen CD339) Jagged canonical Notch ligand 1 Delta-like protein Jagged 1
Synonyms	JAGL1
Description	FUNCTION: Ligand for multiple Notch receptors and involved in the mediation of Notch signaling . May be involved in cell-fate decisions during hematopoiesis . Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation (By similarity). Enhances fibroblast growth factor-induced angiogenesis (in vitro). . FUNCTION: Putative Notch ligand involved in the mediation of Notch signaling. .
Accessions	ENST00000613518.1 P78504 A0A087WXH5 B7U6M8 ENST00000622545.1 Q4KMR2 ENST00000254958.10 [P78504-1] B5M914 A0A087X1E8 B7U6M9

JAG1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review