ISL2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of ISL2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ISL2 at tissue level.

III. Associated gene sets

GO_0007409Biological processaxonogenesis
GO_0021520Biological processspinal cord motor neuron cell fate specification
GO_0048665Biological processneuron fate specification
GO_0045665Biological processnegative regulation of neuron differentiation
GO_0021524Biological processvisceral motor neuron differentiation
GO_0031290Biological processretinal ganglion cell axon guidance
GO_0048935Biological processperipheral nervous system neuron development
GO_0048666Biological processneuron development
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0005515Molecular functionprotein binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0000987Molecular functioncis-regulatory region sequence-specific DNA binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameISL2
Protein nameInsulin gene enhancer protein ISL-2 (Islet-2)
ISL LIM homeobox 2
Insulin gene enhancer protein ISL-2
Synonyms
DescriptionFUNCTION: Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. .

AccessionsH0YN25
ENST00000290759.9
Q96A47
ENST00000558656.1
F1T0J9