Name | Number of supported studies | Average coverage | |
---|---|---|---|
astrocyte | 15 studies | 44% ± 20% | |
ciliated cell | 14 studies | 32% ± 12% | |
glutamatergic neuron | 8 studies | 37% ± 23% | |
retinal rod cell | 7 studies | 30% ± 9% | |
retinal cone cell | 7 studies | 35% ± 14% | |
GABAergic neuron | 7 studies | 36% ± 18% | |
interneuron | 6 studies | 39% ± 25% | |
neuron | 4 studies | 24% ± 10% | |
endothelial cell | 4 studies | 30% ± 13% | |
oligodendrocyte precursor cell | 4 studies | 21% ± 5% | |
epithelial cell | 4 studies | 32% ± 12% | |
adipocyte | 4 studies | 27% ± 5% | |
oligodendrocyte | 4 studies | 36% ± 9% | |
GABAergic interneuron | 3 studies | 22% ± 4% | |
ependymal cell | 3 studies | 61% ± 16% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
breast | 100% | 1862.46 | 458 / 459 | 94% | 4.18 | 1054 / 1118 |
prostate | 100% | 2472.45 | 245 / 245 | 94% | 2.64 | 471 / 502 |
thymus | 100% | 2916.92 | 653 / 653 | 94% | 4.59 | 567 / 605 |
esophagus | 100% | 1743.60 | 1442 / 1445 | 93% | 3.21 | 171 / 183 |
kidney | 100% | 1451.17 | 89 / 89 | 93% | 3.53 | 840 / 901 |
brain | 99% | 2063.15 | 2627 / 2642 | 92% | 3.56 | 651 / 705 |
lung | 100% | 1695.76 | 576 / 578 | 90% | 2.43 | 1038 / 1155 |
ovary | 100% | 3920.66 | 180 / 180 | 88% | 2.40 | 379 / 430 |
pancreas | 97% | 914.97 | 319 / 328 | 90% | 2.63 | 160 / 178 |
adrenal gland | 99% | 1081.56 | 256 / 258 | 88% | 2.60 | 202 / 230 |
uterus | 100% | 3259.98 | 170 / 170 | 86% | 2.69 | 395 / 459 |
bladder | 100% | 1682.00 | 21 / 21 | 82% | 2.28 | 414 / 504 |
stomach | 99% | 1635.60 | 357 / 359 | 76% | 1.69 | 216 / 286 |
intestine | 97% | 1635.77 | 933 / 966 | 73% | 1.44 | 383 / 527 |
skin | 100% | 1340.20 | 1801 / 1809 | 68% | 1.98 | 323 / 472 |
ureter | 0% | 0 | 0 / 0 | 100% | 1.03 | 1 / 1 |
blood vessel | 100% | 2150.47 | 1331 / 1335 | 0% | 0 | 0 / 0 |
spleen | 99% | 906.32 | 239 / 241 | 0% | 0 | 0 / 0 |
adipose | 99% | 1491.08 | 1188 / 1204 | 0% | 0 | 0 / 0 |
heart | 93% | 1276.51 | 802 / 861 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 80% | 2.22 | 36 / 45 |
muscle | 60% | 355.35 | 479 / 803 | 0% | 0 | 0 / 0 |
liver | 27% | 136.03 | 61 / 226 | 20% | 0.42 | 81 / 406 |
eye | 0% | 0 | 0 / 0 | 46% | 1.22 | 37 / 80 |
peripheral blood | 0% | 0.44 | 1 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0008589 | Biological process | regulation of smoothened signaling pathway |
GO_1905515 | Biological process | non-motile cilium assembly |
GO_0060271 | Biological process | cilium assembly |
GO_0030216 | Biological process | keratinocyte differentiation |
GO_0007224 | Biological process | smoothened signaling pathway |
GO_0044458 | Biological process | motile cilium assembly |
GO_0060173 | Biological process | limb development |
GO_0031069 | Biological process | hair follicle morphogenesis |
GO_0051782 | Biological process | negative regulation of cell division |
GO_0042733 | Biological process | embryonic digit morphogenesis |
GO_0051301 | Biological process | cell division |
GO_0033365 | Biological process | protein localization to organelle |
GO_1902017 | Biological process | regulation of cilium assembly |
GO_0010839 | Biological process | negative regulation of keratinocyte proliferation |
GO_0045880 | Biological process | positive regulation of smoothened signaling pathway |
GO_0016192 | Biological process | vesicle-mediated transport |
GO_0060021 | Biological process | roof of mouth development |
GO_0030278 | Biological process | regulation of ossification |
GO_0042073 | Biological process | intraciliary transport |
GO_0021915 | Biological process | neural tube development |
GO_0021513 | Biological process | spinal cord dorsal/ventral patterning |
GO_0007399 | Biological process | nervous system development |
GO_0043587 | Biological process | tongue morphogenesis |
GO_0001736 | Biological process | establishment of planar polarity |
GO_0031514 | Cellular component | motile cilium |
GO_0005814 | Cellular component | centriole |
GO_0009986 | Cellular component | cell surface |
GO_0005929 | Cellular component | cilium |
GO_0035869 | Cellular component | ciliary transition zone |
GO_0005737 | Cellular component | cytoplasm |
GO_0036064 | Cellular component | ciliary basal body |
GO_0005515 | Molecular function | protein binding |
Gene name | INTU |
Protein name | Protein inturned (Inturned planar cell polarity effector homolog) (PDZ domain-containing protein 6) Inturned planar cell polarity protein |
Synonyms | KIAA1284 PDZK6 PDZD6 |
Description | FUNCTION: Plays a key role in ciliogenesis and embryonic development. Regulator of cilia formation by controlling the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell surface, which in turn is essential for the normal orientation of elongating ciliary microtubules. Plays a key role in definition of cell polarity via its role in ciliogenesis but not via conversion extension. Has an indirect effect on hedgehog signaling (By similarity). Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies . . |
Accessions | H0YA54 ENST00000510766.1 J3QTA5 ENST00000504491.1 ENST00000503952.5 [Q9ULD6-3] H0YAI1 Q9ULD6 ENST00000335251.11 [Q9ULD6-1] ENST00000506283.1 ENST00000503626.5 [Q9ULD6-2] |