INTU report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0008589Biological processregulation of smoothened signaling pathway
GO_1905515Biological processnon-motile cilium assembly
GO_0060271Biological processcilium assembly
GO_0030216Biological processkeratinocyte differentiation
GO_0007224Biological processsmoothened signaling pathway
GO_0044458Biological processmotile cilium assembly
GO_0060173Biological processlimb development
GO_0031069Biological processhair follicle morphogenesis
GO_0051782Biological processnegative regulation of cell division
GO_0042733Biological processembryonic digit morphogenesis
GO_0051301Biological processcell division
GO_0033365Biological processprotein localization to organelle
GO_1902017Biological processregulation of cilium assembly
GO_0010839Biological processnegative regulation of keratinocyte proliferation
GO_0045880Biological processpositive regulation of smoothened signaling pathway
GO_0016192Biological processvesicle-mediated transport
GO_0060021Biological processroof of mouth development
GO_0030278Biological processregulation of ossification
GO_0042073Biological processintraciliary transport
GO_0021915Biological processneural tube development
GO_0021513Biological processspinal cord dorsal/ventral patterning
GO_0007399Biological processnervous system development
GO_0043587Biological processtongue morphogenesis
GO_0001736Biological processestablishment of planar polarity
GO_0031514Cellular componentmotile cilium
GO_0005814Cellular componentcentriole
GO_0009986Cellular componentcell surface
GO_0005929Cellular componentcilium
GO_0035869Cellular componentciliary transition zone
GO_0005737Cellular componentcytoplasm
GO_0036064Cellular componentciliary basal body
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameINTU
Protein nameProtein inturned (Inturned planar cell polarity effector homolog) (PDZ domain-containing protein 6)
Inturned planar cell polarity protein
SynonymsKIAA1284
PDZK6
PDZD6
DescriptionFUNCTION: Plays a key role in ciliogenesis and embryonic development. Regulator of cilia formation by controlling the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell surface, which in turn is essential for the normal orientation of elongating ciliary microtubules. Plays a key role in definition of cell polarity via its role in ciliogenesis but not via conversion extension. Has an indirect effect on hedgehog signaling (By similarity). Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies . .

AccessionsH0YA54
ENST00000510766.1
J3QTA5
ENST00000504491.1
ENST00000503952.5 [Q9ULD6-3]
H0YAI1
Q9ULD6
ENST00000335251.11 [Q9ULD6-1]
ENST00000506283.1
ENST00000503626.5 [Q9ULD6-2]