Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| classical monocyte | 12 studies | 27% ± 8% | |
| conventional dendritic cell | 11 studies | 32% ± 16% | |
| dendritic cell | 9 studies | 28% ± 11% | |
| neutrophil | 9 studies | 47% ± 19% | |
| monocyte | 3 studies | 28% ± 6% | |
| mononuclear phagocyte | 3 studies | 45% ± 16% | |
| myeloid cell | 3 studies | 29% ± 12% | |
| basal cell | 3 studies | 20% ± 4% | |
| regulatory T cell | 3 studies | 17% ± 1% | |
| inflammatory macrophage | 3 studies | 30% ± 6% |
Insufficient scRNA-seq data for expression of IL1R2 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| lung | 85% | 2683.43 | 492 / 578 | 74% | 12.74 | 853 / 1155 |
| liver | 50% | 318.34 | 113 / 226 | 92% | 10.17 | 372 / 406 |
| intestine | 54% | 636.61 | 525 / 966 | 87% | 15.78 | 459 / 527 |
| stomach | 55% | 512.43 | 198 / 359 | 84% | 13.17 | 239 / 286 |
| esophagus | 49% | 1120.24 | 714 / 1445 | 89% | 25.40 | 163 / 183 |
| skin | 75% | 1006.75 | 1352 / 1809 | 30% | 1.48 | 143 / 472 |
| kidney | 52% | 370.40 | 46 / 89 | 52% | 16.48 | 468 / 901 |
| adrenal gland | 73% | 423.28 | 189 / 258 | 29% | 4.13 | 67 / 230 |
| spleen | 97% | 7432.28 | 233 / 241 | 0% | 0 | 0 / 0 |
| pancreas | 6% | 34.56 | 20 / 328 | 90% | 28.55 | 161 / 178 |
| tonsil | 0% | 0 | 0 / 0 | 96% | 85.33 | 43 / 45 |
| bladder | 33% | 328.29 | 7 / 21 | 60% | 7.40 | 303 / 504 |
| uterus | 23% | 173.22 | 39 / 170 | 63% | 14.01 | 287 / 459 |
| peripheral blood | 85% | 52067.48 | 788 / 929 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 72% | 10.61 | 21 / 29 |
| ovary | 11% | 45.92 | 19 / 180 | 53% | 3.38 | 230 / 430 |
| thymus | 20% | 92.68 | 129 / 653 | 35% | 3.13 | 214 / 605 |
| breast | 36% | 197.38 | 163 / 459 | 17% | 1.69 | 187 / 1118 |
| adipose | 52% | 761.37 | 627 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 31% | 250.63 | 419 / 1335 | 0% | 0 | 0 / 0 |
| prostate | 26% | 152.48 | 63 / 245 | 5% | 0.13 | 23 / 502 |
| heart | 24% | 160.60 | 209 / 861 | 0% | 0 | 0 / 0 |
| brain | 2% | 15.15 | 65 / 2642 | 17% | 1.19 | 117 / 705 |
| eye | 0% | 0 | 0 / 0 | 5% | 0.16 | 4 / 80 |
| muscle | 3% | 12.45 | 28 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_2000660 | Biological process | negative regulation of interleukin-1-mediated signaling pathway |
| GO_0006955 | Biological process | immune response |
| GO_0019221 | Biological process | cytokine-mediated signaling pathway |
| GO_0016485 | Biological process | protein processing |
| GO_1900016 | Biological process | negative regulation of cytokine production involved in inflammatory response |
| GO_0032690 | Biological process | negative regulation of interleukin-1 alpha production |
| GO_0010955 | Biological process | negative regulation of protein processing |
| GO_0005576 | Cellular component | extracellular region |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0004908 | Molecular function | interleukin-1 receptor activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0019966 | Molecular function | interleukin-1 binding |
| GO_0004910 | Molecular function | interleukin-1, type II, blocking receptor activity |
| Gene name | IL1R2 |
| Protein name | IL1R2 protein Interleukin 1 receptor type 2 Interleukin-1 receptor type 2 (IL-1R-2) (IL-1RT-2) (IL-1RT2) (CD121 antigen-like family member B) (CDw121b) (IL-1 type II receptor) (Interleukin-1 receptor beta) (IL-1R-beta) (Interleukin-1 receptor type II) (CD antigen CD121b) [Cleaved into: Interleukin-1 receptor type 2, membrane form (mIL-1R2) (mIL-1RII); Interleukin-1 receptor type 2, soluble form (sIL-1R2) (sIL-1RII)] |
| Synonyms | IL1RB |
| Description | FUNCTION: Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competitive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. . |
| Accessions | ENST00000441002.1 [P27930-2] ENST00000457817.5 C9JNR0 ENST00000332549.8 [P27930-1] ENST00000393414.6 [P27930-1] P27930 Q6PIW7 |
