IFT27 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0060271Biological processcilium assembly
GO_0007224Biological processsmoothened signaling pathway
GO_0007283Biological processspermatogenesis
GO_0001822Biological processkidney development
GO_0006886Biological processintracellular protein transport
GO_0060122Biological processinner ear receptor cell stereocilium organization
GO_0016192Biological processvesicle-mediated transport
GO_0090102Biological processcochlea development
GO_0035720Biological processintraciliary anterograde transport
GO_0042073Biological processintraciliary transport
GO_0036126Cellular componentsperm flagellum
GO_0005813Cellular componentcentrosome
GO_0031514Cellular componentmotile cilium
GO_0030992Cellular componentintraciliary transport particle B
GO_0005794Cellular componentGolgi apparatus
GO_0097542Cellular componentciliary tip
GO_0000139Cellular componentGolgi membrane
GO_0097228Cellular componentsperm principal piece
GO_0005929Cellular componentcilium
GO_0005737Cellular componentcytoplasm
GO_0097225Cellular componentsperm midpiece
GO_0005634Cellular componentnucleus
GO_0005525Molecular functionGTP binding
GO_0005515Molecular functionprotein binding
GO_0003924Molecular functionGTPase activity

IV. Literature review

[source]
Gene nameIFT27
Protein nameIntraflagellar transport protein 27 homolog (Putative GTP-binding protein RAY-like) (Rab-like protein 4)
Intraflagellar transport 27
SynonymsRAYL
RABL4
DescriptionFUNCTION: Small GTPase-like component of the intraflagellar transport (IFT) complex B that promotes the exit of the BBSome complex from cilia via its interaction with ARL6 . Not involved in entry of the BBSome complex into cilium. Prevents aggregation of GTP-free ARL6 . Required for hedgehog signaling. Forms a subcomplex within the IFT complex B with IFT25. Its role in intraflagellar transport is mainly seen in tissues rich in ciliated cells such as kidney and testis. Essential for male fertility, spermiogenesis and sperm flagella formation. Plays a role in the early development of the kidney. May be involved in the regulation of ureteric bud initiation (By similarity). .

AccessionsENST00000440696.2
H0Y6C7
ENST00000415653.5
B1AH56
ENST00000430701.5
Q9BW83
B1AH58
ENST00000433985.7 [Q9BW83-1]
ENST00000417951.6
F5GZ09
ENST00000340630.9 [Q9BW83-2]