IFT20 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
ciliated cell	13 studies	35% ± 15%	Explore
conventional dendritic cell	9 studies	28% ± 13%	Explore
endothelial cell	9 studies	22% ± 8%	Explore
classical monocyte	7 studies	26% ± 10%	Explore
fibroblast	7 studies	24% ± 9%	Explore
epithelial cell	4 studies	43% ± 17%	Explore
connective tissue cell	4 studies	23% ± 8%	Explore
B cell	3 studies	22% ± 2%	Explore
CD8-positive, alpha-beta T cell	3 studies	21% ± 4%	Explore
non-classical monocyte	3 studies	31% ± 7%	Explore
retinal bipolar neuron	3 studies	25% ± 7%	Explore
myofibroblast cell	3 studies	16% ± 0%	Explore
pericyte	3 studies	21% ± 4%	Explore
plasma cell	3 studies	22% ± 3%	Explore
macrophage	3 studies	23% ± 2%	Explore
glutamatergic neuron	3 studies	36% ± 21%	Explore
dendritic cell	3 studies	44% ± 20%	Explore
goblet cell	3 studies	27% ± 6%	Explore
interneuron	3 studies	28% ± 16%	Explore
plasmacytoid dendritic cell	3 studies	23% ± 4%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	5 studies	22% ± 5%	Explore
brain	3 studies	34% ± 16%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	774.15	1445 / 1445	100%	10.39	183 / 183
pancreas	100%	1653.21	328 / 328	100%	17.44	178 / 178
stomach	100%	994.98	359 / 359	100%	13.04	286 / 286
lung	100%	824.51	577 / 578	100%	16.96	1155 / 1155
prostate	100%	1085.39	245 / 245	100%	19.72	501 / 502
brain	100%	938.11	2635 / 2642	100%	18.15	705 / 705
breast	100%	813.68	459 / 459	100%	16.86	1114 / 1118
ovary	100%	871.91	180 / 180	100%	11.57	428 / 430
thymus	100%	1085.78	653 / 653	100%	17.48	602 / 605
intestine	100%	973.99	966 / 966	99%	13.84	524 / 527
uterus	100%	922.05	170 / 170	99%	16.42	456 / 459
bladder	100%	911.38	21 / 21	99%	20.49	500 / 504
liver	100%	636.23	226 / 226	99%	12.46	402 / 406
kidney	100%	852.42	89 / 89	98%	11.67	886 / 901
adrenal gland	100%	960.26	258 / 258	97%	11.41	224 / 230
skin	100%	782.22	1806 / 1809	95%	12.22	448 / 472
adipose	100%	740.07	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	12.58	29 / 29
spleen	100%	841.10	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	12.39	45 / 45
ureter	0%	0	0 / 0	100%	14.25	1 / 1
blood vessel	100%	899.99	1333 / 1335	0%	0	0 / 0
heart	96%	396.37	824 / 861	0%	0	0 / 0
peripheral blood	90%	419.15	838 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	83%	7.04	66 / 80
muscle	80%	214.47	639 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0060271	Biological process	cilium assembly
GO_0061512	Biological process	protein localization to cilium
GO_0045198	Biological process	establishment of epithelial cell apical/basal polarity
GO_0007224	Biological process	smoothened signaling pathway
GO_0007283	Biological process	spermatogenesis
GO_0072659	Biological process	protein localization to plasma membrane
GO_0035845	Biological process	photoreceptor cell outer segment organization
GO_0055007	Biological process	cardiac muscle cell differentiation
GO_0051642	Biological process	centrosome localization
GO_0001822	Biological process	kidney development
GO_0061351	Biological process	neural precursor cell proliferation
GO_0060122	Biological process	inner ear receptor cell stereocilium organization
GO_1902017	Biological process	regulation of cilium assembly
GO_2000583	Biological process	regulation of platelet-derived growth factor receptor-alpha signaling pathway
GO_0008542	Biological process	visual learning
GO_0034067	Biological process	protein localization to Golgi apparatus
GO_0036372	Biological process	opsin transport
GO_0090102	Biological process	cochlea development
GO_0045724	Biological process	positive regulation of cilium assembly
GO_2000785	Biological process	regulation of autophagosome assembly
GO_0035720	Biological process	intraciliary anterograde transport
GO_0042073	Biological process	intraciliary transport
GO_0060828	Biological process	regulation of canonical Wnt signaling pathway
GO_0001736	Biological process	establishment of planar polarity
GO_0071806	Biological process	protein transmembrane transport
GO_0005902	Cellular component	microvillus
GO_0032420	Cellular component	stereocilium
GO_0005801	Cellular component	cis-Golgi network
GO_0032391	Cellular component	photoreceptor connecting cilium
GO_0001669	Cellular component	acrosomal vesicle
GO_0001750	Cellular component	photoreceptor outer segment
GO_0005813	Cellular component	centrosome
GO_0031514	Cellular component	motile cilium
GO_0002177	Cellular component	manchette
GO_0030992	Cellular component	intraciliary transport particle B
GO_0005794	Cellular component	Golgi apparatus
GO_0044292	Cellular component	dendrite terminus
GO_0005814	Cellular component	centriole
GO_0097542	Cellular component	ciliary tip
GO_1902636	Cellular component	kinociliary basal body
GO_0000139	Cellular component	Golgi membrane
GO_0005929	Cellular component	cilium
GO_0005737	Cellular component	cytoplasm
GO_0097546	Cellular component	ciliary base
GO_0036064	Cellular component	ciliary basal body
GO_0002046	Molecular function	opsin binding
GO_0031267	Molecular function	small GTPase binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	IFT20
Protein name	Intraflagellar transport protein 20 homolog (hIFT20) Intraflagellar transport 20
Synonyms	hCG_31823
Description	FUNCTION: Part of intraflagellar transport (IFT) particles involved in ciliary process assembly . May play a role in the trafficking of ciliary membrane proteins from the Golgi complex to the cilium . Regulates the platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway. Required for protein stability of E3 ubiquitin ligases CBL and CBLB that mediate ubiquitination and internalization of PDGFRA for proper feedback inhibition of PDGFRA signaling . Essential for male fertility. Plays an important role in spermatogenesis, particularly spermiogenesis, when germ cells form flagella. May play a role in the transport of flagellar proteins ODF2 and SPAG16 to build sperm flagella and in the removal of redundant sperm cytoplasm (By similarity). Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment (By similarity). .
Accessions	ENST00000588477.5 ENST00000395418.8 [Q8IY31-1] A0A087X2B4 J3QRC6 ENST00000578009.5 J3QRH2 J3QR43 ENST00000585313.5 [Q8IY31-1] ENST00000578122.5 Q8IY31 ENST00000585089.5 [Q8IY31-2] J3KRU2 ENST00000578985.5 ENST00000357896.7 [Q8IY31-3] ENST00000579419.5 [Q8IY31-4] ENST00000577498.1

IFT20 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review