IFNL1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of IFNL1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of IFNL1 at tissue level.

III. Associated gene sets

GO_0042531Biological processpositive regulation of tyrosine phosphorylation of STAT protein
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0045581Biological processnegative regulation of T cell differentiation
GO_0045087Biological processinnate immune response
GO_0051607Biological processdefense response to virus
GO_0045345Biological processpositive regulation of MHC class I biosynthetic process
GO_0002829Biological processnegative regulation of type 2 immune response
GO_0098586Biological processcellular response to virus
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0032696Biological processnegative regulation of interleukin-13 production
GO_0043381Biological processnegative regulation of memory T cell differentiation
GO_0032729Biological processpositive regulation of type II interferon production
GO_0050778Biological processpositive regulation of immune response
GO_0032714Biological processnegative regulation of interleukin-5 production
GO_0046427Biological processpositive regulation of receptor signaling pathway via JAK-STAT
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0007259Biological processcell surface receptor signaling pathway via JAK-STAT
GO_0038196Biological processtype III interferon-mediated signaling pathway
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0032002Cellular componentinterleukin-28 receptor complex
GO_0032003Molecular functioninterleukin-28 receptor binding
GO_0005102Molecular functionsignaling receptor binding
GO_0005125Molecular functioncytokine activity

IV. Literature review

[source]
Gene nameIFNL1
Protein nameInterferon lambda-1 (IFN-lambda-1) (Cytokine Zcyto21) (Interleukin-29) (IL-29)
SynonymsZCYTO21
IL29
DescriptionFUNCTION: Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.

AccessionsENST00000709027.1
Q8IU54
ENST00000333625.3