IFIT5 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of IFIT5 at tissue level.

III. Associated gene sets

GO_0051607Biological processdefense response to virus
GO_0045071Biological processnegative regulation of viral genome replication
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0045087Biological processinnate immune response
GO_0032587Cellular componentruffle membrane
GO_0008385Cellular componentIkappaB kinase complex
GO_0015629Cellular componentactin cytoskeleton
GO_0005829Cellular componentcytosol
GO_0045177Cellular componentapical part of cell
GO_0005886Cellular componentplasma membrane
GO_0003690Molecular functiondouble-stranded DNA binding
GO_0000339Molecular functionRNA cap binding
GO_0000049Molecular functiontRNA binding
GO_0008266Molecular functionpoly(U) RNA binding
GO_0005515Molecular functionprotein binding
GO_0003727Molecular functionsingle-stranded RNA binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameIFIT5
Protein nameInterferon induced protein with tetratricopeptide repeats 5
Interferon-induced protein with tetratricopeptide repeats 5 (IFIT-5) (Interferon-induced 58 kDa protein) (Retinoic acid- and interferon-inducible 58 kDa protein) (P58)
SynonymsRI58
ISG58
DescriptionFUNCTION: Interferon-induced RNA-binding protein involved in the human innate immune response. Has a broad and adaptable RNA structure recognition important for RNA recognition specificity in antiviral defense. Binds precursor and processed tRNAs as well as poly-U-tailed tRNA fragments . Specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner . Also recognizes and selectively binds AT-rich dsDNA . Additionally, as a mediator in innate immunity, positively regulates IKK-NFKB signaling by sinergizing the recruitment of IKK to MAP3K7 . .

AccessionsENST00000681163.1
A0A7P0TB01
A0A7P0Z4E6
ENST00000371795.5 [Q13325-1]
A0A7P0T9H9
Q13325
ENST00000679632.1
A0A7P0TBP9
ENST00000680591.1
ENST00000681422.1
ENST00000681348.1 [Q13325-2]