Name | Number of supported studies | Average coverage | |
---|---|---|---|
B cell | 34 studies | 34% ± 12% | |
naive B cell | 20 studies | 47% ± 14% | |
memory B cell | 18 studies | 34% ± 11% | |
plasmacytoid dendritic cell | 9 studies | 30% ± 10% | |
non-classical monocyte | 7 studies | 25% ± 7% | |
classical monocyte | 6 studies | 27% ± 9% | |
macrophage | 6 studies | 20% ± 4% | |
CD16-negative, CD56-bright natural killer cell, human | 5 studies | 17% ± 2% | |
immature B cell | 5 studies | 49% ± 14% | |
natural killer cell | 4 studies | 21% ± 4% | |
precursor B cell | 3 studies | 33% ± 11% | |
germinal center B cell | 3 studies | 26% ± 3% | |
astrocyte | 3 studies | 38% ± 10% |
Insufficient scRNA-seq data for expression of HVCN1 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 99% | 482.14 | 2615 / 2642 | 100% | 11.07 | 704 / 705 |
lung | 98% | 375.45 | 569 / 578 | 97% | 4.98 | 1116 / 1155 |
breast | 97% | 255.64 | 447 / 459 | 97% | 3.63 | 1088 / 1118 |
ovary | 100% | 443.01 | 180 / 180 | 92% | 2.79 | 394 / 430 |
thymus | 94% | 206.13 | 615 / 653 | 96% | 3.42 | 580 / 605 |
prostate | 98% | 258.93 | 241 / 245 | 88% | 2.28 | 442 / 502 |
uterus | 99% | 402.37 | 169 / 170 | 87% | 3.08 | 399 / 459 |
bladder | 100% | 265.52 | 21 / 21 | 86% | 2.96 | 434 / 504 |
intestine | 98% | 351.69 | 942 / 966 | 79% | 2.53 | 414 / 527 |
stomach | 86% | 167.73 | 308 / 359 | 85% | 3.08 | 242 / 286 |
adrenal gland | 96% | 191.01 | 247 / 258 | 72% | 1.92 | 165 / 230 |
kidney | 75% | 137.85 | 67 / 89 | 91% | 5.10 | 820 / 901 |
esophagus | 81% | 165.24 | 1172 / 1445 | 79% | 2.35 | 144 / 183 |
skin | 62% | 82.55 | 1125 / 1809 | 89% | 5.87 | 419 / 472 |
pancreas | 14% | 17.18 | 46 / 328 | 94% | 5.12 | 167 / 178 |
lymph node | 0% | 0 | 0 / 0 | 100% | 41.78 | 29 / 29 |
spleen | 100% | 1688.22 | 241 / 241 | 0% | 0 | 0 / 0 |
heart | 99% | 459.22 | 856 / 861 | 0% | 0 | 0 / 0 |
adipose | 99% | 358.67 | 1195 / 1204 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 99% | 6.02 | 79 / 80 |
peripheral blood | 99% | 1932.98 | 917 / 929 | 0% | 0 | 0 / 0 |
blood vessel | 97% | 271.15 | 1291 / 1335 | 0% | 0 | 0 / 0 |
muscle | 94% | 216.64 | 757 / 803 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 93% | 6.35 | 42 / 45 |
liver | 15% | 17.01 | 33 / 226 | 48% | 1.24 | 195 / 406 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0045454 | Biological process | cell redox homeostasis |
GO_0071467 | Biological process | cellular response to pH |
GO_0045087 | Biological process | innate immune response |
GO_0071294 | Biological process | cellular response to zinc ion |
GO_0060046 | Biological process | regulation of acrosome reaction |
GO_0009268 | Biological process | response to pH |
GO_1903426 | Biological process | regulation of reactive oxygen species biosynthetic process |
GO_0010043 | Biological process | response to zinc ion |
GO_0032930 | Biological process | positive regulation of superoxide anion generation |
GO_0051453 | Biological process | regulation of intracellular pH |
GO_0007338 | Biological process | single fertilization |
GO_1902600 | Biological process | proton transmembrane transport |
GO_0016324 | Cellular component | apical plasma membrane |
GO_0030667 | Cellular component | secretory granule membrane |
GO_0036126 | Cellular component | sperm flagellum |
GO_0035579 | Cellular component | specific granule membrane |
GO_0005886 | Cellular component | plasma membrane |
GO_0016020 | Cellular component | membrane |
GO_0034702 | Cellular component | monoatomic ion channel complex |
GO_0030670 | Cellular component | phagocytic vesicle membrane |
GO_0042803 | Molecular function | protein homodimerization activity |
GO_0030171 | Molecular function | voltage-gated proton channel activity |
GO_0022843 | Molecular function | voltage-gated monoatomic cation channel activity |
GO_0042802 | Molecular function | identical protein binding |
Gene name | HVCN1 |
Protein name | Voltage-gated hydrogen channel 1 (Hydrogen voltage-gated channel 1) Hydrogen voltage gated channel 1 Voltage-gated hydrogen channel 1 (Hydrogen voltage-gated channel 1) (HV1) (Voltage sensor domain-only protein) |
Synonyms | VSOP UNQ578/PRO1140 |
Description | FUNCTION: Voltage-gated proton-selective channel that conducts outward proton currents in response to intracellular acidification. Lacks a canonical ion-channel pore domain and mediates proton permeability via its voltage sensor domain . Appears to play a dominant role in regulation of CO2/HCO3(-)/H(+) equilibrium in sperm flagellum. Prevents the acidification resulting from HCO3(-) synthesis and thus sustains high HCO3(-) levels inside sperm for capacitation . Provides for proton efflux that compensates for electron charge generated by NADPH oxidase activity either in the extracellular or phagosomal compartments, thus enabling the production of high levels of bactericidal reactive oxygen species during the respiratory burst . Opens when the pH of airway surface liquid exceeds 7 and contributes to respiratory epithelial acid secretion to maintain pH in the mucosa . . |
Accessions | ENST00000242607.13 [Q96D96-1] ENST00000546713.5 ENST00000549442.5 ENST00000356742.9 [Q96D96-1] F8VS40 ENST00000548312.5 [Q96D96-3] ENST00000547887.1 F8W0B3 Q96D96 ENST00000439744.6 [Q96D96-4] D2KFF9 ENST00000620084.4 [Q96D96-1] F8VPF7 |