HVCN1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of HVCN1 at tissue level.

III. Associated gene sets

GO_0045454Biological processcell redox homeostasis
GO_0071467Biological processcellular response to pH
GO_0045087Biological processinnate immune response
GO_0071294Biological processcellular response to zinc ion
GO_0060046Biological processregulation of acrosome reaction
GO_0009268Biological processresponse to pH
GO_1903426Biological processregulation of reactive oxygen species biosynthetic process
GO_0010043Biological processresponse to zinc ion
GO_0032930Biological processpositive regulation of superoxide anion generation
GO_0051453Biological processregulation of intracellular pH
GO_0007338Biological processsingle fertilization
GO_1902600Biological processproton transmembrane transport
GO_0016324Cellular componentapical plasma membrane
GO_0030667Cellular componentsecretory granule membrane
GO_0036126Cellular componentsperm flagellum
GO_0035579Cellular componentspecific granule membrane
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0034702Cellular componentmonoatomic ion channel complex
GO_0030670Cellular componentphagocytic vesicle membrane
GO_0042803Molecular functionprotein homodimerization activity
GO_0030171Molecular functionvoltage-gated proton channel activity
GO_0022843Molecular functionvoltage-gated monoatomic cation channel activity
GO_0042802Molecular functionidentical protein binding

IV. Literature review

[source]
Gene nameHVCN1
Protein nameVoltage-gated hydrogen channel 1 (Hydrogen voltage-gated channel 1)
Hydrogen voltage gated channel 1
Voltage-gated hydrogen channel 1 (Hydrogen voltage-gated channel 1) (HV1) (Voltage sensor domain-only protein)
SynonymsVSOP
UNQ578/PRO1140
DescriptionFUNCTION: Voltage-gated proton-selective channel that conducts outward proton currents in response to intracellular acidification. Lacks a canonical ion-channel pore domain and mediates proton permeability via its voltage sensor domain . Appears to play a dominant role in regulation of CO2/HCO3(-)/H(+) equilibrium in sperm flagellum. Prevents the acidification resulting from HCO3(-) synthesis and thus sustains high HCO3(-) levels inside sperm for capacitation . Provides for proton efflux that compensates for electron charge generated by NADPH oxidase activity either in the extracellular or phagosomal compartments, thus enabling the production of high levels of bactericidal reactive oxygen species during the respiratory burst . Opens when the pH of airway surface liquid exceeds 7 and contributes to respiratory epithelial acid secretion to maintain pH in the mucosa . .

AccessionsENST00000242607.13 [Q96D96-1]
ENST00000546713.5
ENST00000549442.5
ENST00000356742.9 [Q96D96-1]
F8VS40
ENST00000548312.5 [Q96D96-3]
ENST00000547887.1
F8W0B3
Q96D96
ENST00000439744.6 [Q96D96-4]
D2KFF9
ENST00000620084.4 [Q96D96-1]
F8VPF7