Insufficient scRNA-seq data for expression of HNF1A at single-cell level.
Insufficient scRNA-seq data for expression of HNF1A at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
liver | 100% | 810.91 | 226 / 226 | 90% | 9.08 | 364 / 406 |
stomach | 89% | 275.53 | 318 / 359 | 97% | 13.43 | 276 / 286 |
kidney | 100% | 667.16 | 89 / 89 | 83% | 9.64 | 747 / 901 |
pancreas | 100% | 391.60 | 328 / 328 | 74% | 3.86 | 131 / 178 |
intestine | 67% | 303.57 | 643 / 966 | 95% | 12.24 | 502 / 527 |
esophagus | 4% | 2.22 | 61 / 1445 | 48% | 7.00 | 88 / 183 |
bladder | 5% | 1.24 | 1 / 21 | 24% | 2.86 | 122 / 504 |
lung | 3% | 1.04 | 17 / 578 | 23% | 2.14 | 265 / 1155 |
uterus | 4% | 2.29 | 7 / 170 | 10% | 0.78 | 48 / 459 |
prostate | 2% | 0.51 | 4 / 245 | 9% | 0.57 | 46 / 502 |
breast | 2% | 2.51 | 10 / 459 | 1% | 0.02 | 7 / 1118 |
ovary | 0% | 0 | 0 / 180 | 3% | 0.30 | 12 / 430 |
adrenal gland | 0% | 0 | 0 / 258 | 1% | 0.15 | 2 / 230 |
peripheral blood | 1% | 0.30 | 5 / 929 | 0% | 0 | 0 / 0 |
adipose | 0% | 0.36 | 6 / 1204 | 0% | 0 | 0 / 0 |
spleen | 0% | 1.16 | 1 / 241 | 0% | 0 | 0 / 0 |
skin | 0% | 0.08 | 5 / 1809 | 0% | 0 | 0 / 472 |
blood vessel | 0% | 0.04 | 2 / 1335 | 0% | 0 | 0 / 0 |
brain | 0% | 0.01 | 1 / 2642 | 0% | 0 | 0 / 705 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
heart | 0% | 0 | 0 / 861 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
muscle | 0% | 0 | 0 / 803 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
thymus | 0% | 0 | 0 / 653 | 0% | 0 | 0 / 605 |
tonsil | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 45 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0031016 | Biological process | pancreas development |
GO_0035565 | Biological process | regulation of pronephros size |
GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
GO_0035623 | Biological process | renal glucose absorption |
GO_0001889 | Biological process | liver development |
GO_0060261 | Biological process | positive regulation of transcription initiation by RNA polymerase II |
GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
GO_0030073 | Biological process | insulin secretion |
GO_0046323 | Biological process | glucose import |
GO_0042593 | Biological process | glucose homeostasis |
GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
GO_0032991 | Cellular component | protein-containing complex |
GO_0005737 | Cellular component | cytoplasm |
GO_0000785 | Cellular component | chromatin |
GO_0005634 | Cellular component | nucleus |
GO_0003677 | Molecular function | DNA binding |
GO_0000978 | Molecular function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
GO_0001228 | Molecular function | DNA-binding transcription activator activity, RNA polymerase II-specific |
GO_0000981 | Molecular function | DNA-binding transcription factor activity, RNA polymerase II-specific |
GO_0000976 | Molecular function | transcription cis-regulatory region binding |
GO_0003700 | Molecular function | DNA-binding transcription factor activity |
GO_0046983 | Molecular function | protein dimerization activity |
GO_0005515 | Molecular function | protein binding |
Gene name | HNF1A |
Protein name | HNF1 alpha A splice variant 3 HNF1 homeobox A (Transcription factor 1, hepatic LF-B1, hepatic nuclear factor (HNF1), albumin proximal factor, isoform CRA_b) Hepatocyte nuclear factor 1-alpha (HNF-1-alpha) (HNF-1A) (Liver-specific transcription factor LF-B1) (LFB1) (Transcription factor 1) (TCF-1) HNF1 alpha A splice variant 2 (HNF1 homeobox A) HNF1 alpha A splice variant 5 HNF1 alpha A splice variant 7 HNF1 alpha B splice variant 6 HNF1 alpha A splice variant 4 HNF1 alpha B splice variant 3 (HNF1 alpha B splice variant 5) HNF1 alpha A splice variant 6 HNF1 alpha A splice variant 1 HNF1 alpha A splice variant 8 HNF1 homeobox A |
Synonyms | hCG_27361 TCF1 |
Description | FUNCTION: Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver (By similarity). Binds to the inverted palindrome 5'-GTTAATNATTAAC-3' . Activates the transcription of CYP1A2, CYP2E1 and CYP3A11 (By similarity). .; FUNCTION: (Microbial infection) Plays a crucial role for hepatitis B virus gene transcription and DNA replication. Mechanistically, synergistically cooperates with NR5A2 to up-regulate the activity of one of the critical cis-elements in the hepatitis B virus genome enhancer II (ENII). . |
Accessions | ENST00000538646.5 [P20823-4] U3KQS6 E0YMI9 ENST00000541395.5 E0YMK2 ENST00000544574.5 ENST00000544413.2 E0YMJ4 F5H0K0 E0YMJ2 E0YMK3 E0YMJ0 ENST00000541924.5 [P20823-5] F5H3Z5 A0A0A0MTK8 P20823 ENST00000257555.11 E0YMI7 E0YMI8 E0YMJ3 ENST00000400024.6 A0A0A0MQU7 E0YMJ1 ENST00000560968.6 ENST00000540108.1 [P20823-8] |