Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| epithelial cell | 7 studies | 39% ± 16% | |
| goblet cell | 7 studies | 29% ± 9% | |
| intestinal crypt stem cell | 6 studies | 36% ± 12% | |
| hepatocyte | 5 studies | 69% ± 18% | |
| enterocyte | 4 studies | 26% ± 8% | |
| progenitor cell | 4 studies | 45% ± 11% | |
| transit amplifying cell | 4 studies | 30% ± 8% | |
| renal principal cell | 4 studies | 39% ± 22% | |
| endothelial cell | 3 studies | 21% ± 7% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| liver | 100% | 68460.29 | 226 / 226 | 91% | 1161.59 | 371 / 406 |
| prostate | 84% | 1908.04 | 207 / 245 | 66% | 124.73 | 329 / 502 |
| stomach | 75% | 5536.45 | 269 / 359 | 62% | 204.28 | 176 / 286 |
| intestine | 56% | 11389.84 | 540 / 966 | 67% | 207.63 | 352 / 527 |
| kidney | 98% | 5913.19 | 87 / 89 | 22% | 42.76 | 198 / 901 |
| bladder | 57% | 2898.67 | 12 / 21 | 53% | 273.19 | 266 / 504 |
| breast | 45% | 1097.22 | 208 / 459 | 26% | 82.42 | 294 / 1118 |
| skin | 60% | 983.25 | 1085 / 1809 | 0% | 0 | 0 / 472 |
| pancreas | 27% | 322.16 | 89 / 328 | 31% | 66.60 | 56 / 178 |
| heart | 49% | 1425.02 | 419 / 861 | 0% | 0 | 0 / 0 |
| esophagus | 14% | 135.20 | 204 / 1445 | 24% | 82.84 | 44 / 183 |
| muscle | 24% | 337.40 | 194 / 803 | 0% | 0 | 0 / 0 |
| lung | 4% | 33.56 | 26 / 578 | 9% | 17.63 | 109 / 1155 |
| uterus | 1% | 6.56 | 1 / 170 | 6% | 10.88 | 27 / 459 |
| thymus | 4% | 30.88 | 26 / 653 | 1% | 0.84 | 4 / 605 |
| adipose | 3% | 31.41 | 41 / 1204 | 0% | 0 | 0 / 0 |
| peripheral blood | 3% | 41.44 | 30 / 929 | 0% | 0 | 0 / 0 |
| ovary | 0% | 0 | 0 / 180 | 3% | 2.50 | 11 / 430 |
| adrenal gland | 1% | 4.59 | 3 / 258 | 0% | 0 | 0 / 230 |
| blood vessel | 1% | 5.85 | 8 / 1335 | 0% | 0 | 0 / 0 |
| spleen | 0% | 69.95 | 1 / 241 | 0% | 0 | 0 / 0 |
| brain | 0% | 0.98 | 3 / 2642 | 0% | 0.06 | 1 / 705 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 45 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0007584 | Biological process | response to nutrient |
| GO_0033574 | Biological process | response to testosterone |
| GO_0010038 | Biological process | response to metal ion |
| GO_0030324 | Biological process | lung development |
| GO_0032869 | Biological process | cellular response to insulin stimulus |
| GO_0070543 | Biological process | response to linoleic acid |
| GO_0009266 | Biological process | response to temperature stimulus |
| GO_0007494 | Biological process | midgut development |
| GO_0001822 | Biological process | kidney development |
| GO_0001889 | Biological process | liver development |
| GO_0033762 | Biological process | response to glucagon |
| GO_0045471 | Biological process | response to ethanol |
| GO_0006084 | Biological process | acetyl-CoA metabolic process |
| GO_0042594 | Biological process | response to starvation |
| GO_0034284 | Biological process | response to monosaccharide |
| GO_0060416 | Biological process | response to growth hormone |
| GO_0051591 | Biological process | response to cAMP |
| GO_0033555 | Biological process | multicellular organismal response to stress |
| GO_0034696 | Biological process | response to prostaglandin F |
| GO_0071230 | Biological process | cellular response to amino acid stimulus |
| GO_0060612 | Biological process | adipose tissue development |
| GO_0071222 | Biological process | cellular response to lipopolysaccharide |
| GO_0071385 | Biological process | cellular response to glucocorticoid stimulus |
| GO_0046951 | Biological process | ketone body biosynthetic process |
| GO_0009410 | Biological process | response to xenobiotic stimulus |
| GO_0034014 | Biological process | response to triglyceride |
| GO_0006695 | Biological process | cholesterol biosynthetic process |
| GO_0010142 | Biological process | farnesyl diphosphate biosynthetic process, mevalonate pathway |
| GO_0071398 | Biological process | cellular response to fatty acid |
| GO_0005739 | Cellular component | mitochondrion |
| GO_0005759 | Cellular component | mitochondrial matrix |
| GO_0004421 | Molecular function | hydroxymethylglutaryl-CoA synthase activity |
| GO_0042802 | Molecular function | identical protein binding |
| Gene name | HMGCS2 |
| Protein name | Hydroxymethylglutaryl-CoA synthase, mitochondrial (HMG-CoA synthase) (EC 2.3.3.10) (3-hydroxy-3-methylglutaryl coenzyme A synthase) |
| Synonyms | |
| Description | FUNCTION: Catalyzes the first irreversible step in ketogenesis, condensing acetyl-CoA to acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate. . |
| Accessions | P54868 ENST00000369406.8 [P54868-1] ENST00000544913.2 [P54868-2] |
