Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| type II pneumocyte | 11 studies | 32% ± 12% | |
| astrocyte | 11 studies | 30% ± 11% | |
| oligodendrocyte precursor cell | 11 studies | 26% ± 13% | |
| epithelial cell | 8 studies | 37% ± 17% | |
| retinal ganglion cell | 7 studies | 63% ± 22% | |
| ciliated cell | 7 studies | 25% ± 5% | |
| goblet cell | 7 studies | 26% ± 11% | |
| neuron | 6 studies | 28% ± 10% | |
| endothelial cell | 6 studies | 31% ± 13% | |
| GABAergic neuron | 6 studies | 40% ± 10% | |
| glutamatergic neuron | 6 studies | 45% ± 19% | |
| amacrine cell | 5 studies | 28% ± 6% | |
| basal cell | 5 studies | 28% ± 9% | |
| retinal pigment epithelial cell | 5 studies | 32% ± 15% | |
| hepatocyte | 5 studies | 47% ± 27% | |
| club cell | 5 studies | 19% ± 3% | |
| T cell | 4 studies | 23% ± 8% | |
| fibroblast | 4 studies | 18% ± 1% | |
| adipocyte | 4 studies | 32% ± 18% | |
| keratinocyte | 4 studies | 23% ± 6% | |
| progenitor cell | 3 studies | 26% ± 3% | |
| naive B cell | 3 studies | 18% ± 2% | |
| enterocyte | 3 studies | 20% ± 5% | |
| respiratory goblet cell | 3 studies | 21% ± 6% | |
| secretory cell | 3 studies | 22% ± 6% | |
| luminal cell of prostate epithelium | 3 studies | 27% ± 7% | |
| pancreatic ductal cell | 3 studies | 34% ± 10% | |
| neural progenitor cell | 3 studies | 39% ± 17% | |
| mast cell | 3 studies | 25% ± 7% | |
| megakaryocyte-erythroid progenitor cell | 3 studies | 19% ± 3% | |
| transit amplifying cell | 3 studies | 28% ± 12% | |
| interneuron | 3 studies | 33% ± 13% | |
| oligodendrocyte | 3 studies | 31% ± 11% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| stomach | 99% | 3673.72 | 355 / 359 | 97% | 33.94 | 278 / 286 |
| breast | 99% | 1979.96 | 454 / 459 | 96% | 32.07 | 1077 / 1118 |
| liver | 100% | 10155.46 | 226 / 226 | 95% | 59.89 | 386 / 406 |
| intestine | 97% | 3061.86 | 939 / 966 | 97% | 42.95 | 512 / 527 |
| brain | 95% | 3362.80 | 2520 / 2642 | 99% | 58.98 | 697 / 705 |
| lung | 95% | 4544.94 | 547 / 578 | 97% | 45.64 | 1116 / 1155 |
| esophagus | 92% | 6451.78 | 1332 / 1445 | 97% | 46.86 | 178 / 183 |
| pancreas | 93% | 1871.70 | 304 / 328 | 97% | 28.33 | 172 / 178 |
| bladder | 95% | 1773.29 | 20 / 21 | 94% | 33.23 | 472 / 504 |
| uterus | 98% | 2368.31 | 167 / 170 | 90% | 32.24 | 415 / 459 |
| prostate | 95% | 1768.82 | 232 / 245 | 94% | 24.63 | 470 / 502 |
| skin | 100% | 6706.16 | 1804 / 1809 | 82% | 19.08 | 388 / 472 |
| adrenal gland | 99% | 6406.29 | 256 / 258 | 80% | 65.35 | 184 / 230 |
| kidney | 94% | 1993.64 | 84 / 89 | 83% | 15.62 | 752 / 901 |
| thymus | 97% | 1819.06 | 632 / 653 | 78% | 10.59 | 469 / 605 |
| ovary | 94% | 2492.28 | 169 / 180 | 73% | 11.87 | 315 / 430 |
| ureter | 0% | 0 | 0 / 0 | 100% | 10.64 | 1 / 1 |
| adipose | 98% | 2058.01 | 1183 / 1204 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 96% | 39.17 | 43 / 45 |
| blood vessel | 91% | 1583.37 | 1218 / 1335 | 0% | 0 | 0 / 0 |
| spleen | 89% | 1229.74 | 214 / 241 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 76% | 12.46 | 22 / 29 |
| muscle | 69% | 847.60 | 553 / 803 | 0% | 0 | 0 / 0 |
| heart | 60% | 870.74 | 517 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 28% | 2.65 | 22 / 80 |
| peripheral blood | 23% | 1728.44 | 214 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0006629 | Biological process | lipid metabolic process |
| GO_0006695 | Biological process | cholesterol biosynthetic process |
| GO_0010142 | Biological process | farnesyl diphosphate biosynthetic process, mevalonate pathway |
| GO_0006084 | Biological process | acetyl-CoA metabolic process |
| GO_0005829 | Cellular component | cytosol |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0042803 | Molecular function | protein homodimerization activity |
| GO_0004421 | Molecular function | hydroxymethylglutaryl-CoA synthase activity |
| Gene name | HMGCS1 |
| Protein name | Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMG-CoA synthase) (EC 2.3.3.10) (3-hydroxy-3-methylglutaryl coenzyme A synthase) 3-hydroxy-3-methylglutaryl-CoA synthase 1 |
| Synonyms | HMGCS |
| Description | FUNCTION: Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate, a precursor for cholesterol synthesis. . |
| Accessions | ENST00000325110.11 Q01581 ENST00000511774.1 ENST00000433297.2 D6RIW1 |