Name | Number of supported studies | Average coverage | |
---|---|---|---|
B cell | 40 studies | 45% ± 15% | |
macrophage | 37 studies | 52% ± 19% | |
conventional dendritic cell | 29 studies | 67% ± 17% | |
dendritic cell | 23 studies | 54% ± 25% | |
classical monocyte | 21 studies | 33% ± 12% | |
memory B cell | 20 studies | 47% ± 11% | |
naive B cell | 20 studies | 52% ± 12% | |
plasmacytoid dendritic cell | 19 studies | 52% ± 13% | |
monocyte | 18 studies | 36% ± 17% | |
non-classical monocyte | 17 studies | 28% ± 13% | |
myeloid cell | 10 studies | 49% ± 19% | |
alveolar macrophage | 7 studies | 46% ± 16% | |
leukocyte | 7 studies | 30% ± 9% | |
microglial cell | 7 studies | 46% ± 28% | |
mononuclear phagocyte | 6 studies | 58% ± 24% | |
precursor B cell | 6 studies | 39% ± 8% | |
immature B cell | 6 studies | 58% ± 6% | |
endothelial cell | 5 studies | 21% ± 4% | |
enterocyte | 4 studies | 22% ± 4% | |
germinal center B cell | 4 studies | 47% ± 20% | |
monocyte-derived dendritic cell | 3 studies | 68% ± 28% | |
hematopoietic precursor cell | 3 studies | 30% ± 11% | |
capillary endothelial cell | 3 studies | 27% ± 3% | |
pro-B cell | 3 studies | 27% ± 3% | |
endothelial cell of vascular tree | 3 studies | 19% ± 4% | |
intermediate monocyte | 3 studies | 46% ± 17% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
thymus | 100% | 2518.32 | 652 / 653 | 99% | 52.46 | 599 / 605 |
kidney | 99% | 1619.36 | 88 / 89 | 92% | 36.68 | 832 / 901 |
breast | 99% | 1710.42 | 455 / 459 | 92% | 25.41 | 1024 / 1118 |
lung | 100% | 4051.71 | 577 / 578 | 89% | 35.95 | 1025 / 1155 |
prostate | 90% | 878.18 | 221 / 245 | 82% | 38.55 | 413 / 502 |
uterus | 92% | 838.41 | 156 / 170 | 80% | 28.37 | 366 / 459 |
intestine | 90% | 1797.92 | 869 / 966 | 69% | 17.66 | 361 / 527 |
stomach | 73% | 691.47 | 263 / 359 | 75% | 20.46 | 215 / 286 |
skin | 69% | 652.48 | 1255 / 1809 | 76% | 27.47 | 359 / 472 |
bladder | 76% | 675.38 | 16 / 21 | 65% | 17.89 | 326 / 504 |
adrenal gland | 97% | 2129.17 | 250 / 258 | 41% | 6.14 | 94 / 230 |
esophagus | 75% | 533.23 | 1078 / 1445 | 63% | 11.20 | 115 / 183 |
ovary | 43% | 289.66 | 77 / 180 | 90% | 32.80 | 387 / 430 |
pancreas | 27% | 192.19 | 87 / 328 | 89% | 29.16 | 158 / 178 |
brain | 35% | 341.45 | 915 / 2642 | 77% | 24.89 | 540 / 705 |
lymph node | 0% | 0 | 0 / 0 | 100% | 225.92 | 29 / 29 |
spleen | 100% | 7054.68 | 241 / 241 | 0% | 0 | 0 / 0 |
adipose | 98% | 2182.66 | 1183 / 1204 | 0% | 0 | 0 / 0 |
peripheral blood | 96% | 3593.34 | 894 / 929 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 89% | 33.45 | 40 / 45 |
blood vessel | 84% | 1134.30 | 1117 / 1335 | 0% | 0 | 0 / 0 |
liver | 23% | 121.37 | 51 / 226 | 47% | 9.30 | 191 / 406 |
heart | 48% | 293.21 | 416 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 26% | 4.99 | 21 / 80 |
muscle | 16% | 81.03 | 131 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_2001190 | Biological process | positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell |
GO_0019886 | Biological process | antigen processing and presentation of exogenous peptide antigen via MHC class II |
GO_0002250 | Biological process | adaptive immune response |
GO_0050870 | Biological process | positive regulation of T cell activation |
GO_0042102 | Biological process | positive regulation of T cell proliferation |
GO_0050778 | Biological process | positive regulation of immune response |
GO_0002399 | Biological process | MHC class II protein complex assembly |
GO_0002503 | Biological process | peptide antigen assembly with MHC class II protein complex |
GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
GO_0031902 | Cellular component | late endosome membrane |
GO_0042613 | Cellular component | MHC class II protein complex |
GO_0005765 | Cellular component | lysosomal membrane |
GO_0023026 | Molecular function | MHC class II protein complex binding |
GO_0005515 | Molecular function | protein binding |
GO_0042605 | Molecular function | peptide antigen binding |
Gene name | HLA-DMB |
Protein name | HLA class II histocompatibility antigen, DM beta chain (MHC class II antigen DMB) (Really interesting new gene 7 protein) MHC class II antigen Major histocompatibility complex, class II, DM beta MHC class II HLA-DMB HLA-DMB MHC class II antigen HLA-DM beta chain HLA-DMB (MHC class II antigen) HLA-DMB protein HLA class II histocompatibility antigen, DM beta chain MHC class II antigen beta chain |
Synonyms | RING7 DMB |
Description | FUNCTION: Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. . |
Accessions | A0A140T9C9 ENST00000415927.1 A0A140T9B6 ENST00000428864.6 ENST00000418107.3 ENST00000438310.5 ENST00000440078.6 ENST00000421456.5 ENST00000428420.6 A0A140T9I2 P28068 A0A140T9R2 Q52RG1 A0A0G2JIJ2 A0A1V0E3K4 A0A140T9U6 ENST00000383231.6 ENST00000395312.7 ENST00000413617.6 A0A140T9C6 A0A1V0E3P2 A8CGH8 Q6LEU6 A0A140T946 ENST00000448590.1 ENST00000430099.1 ENST00000447454.6 ENST00000414017.5 A0A1V0E3L6 ENST00000418759.6 A0A140T9T8 ENST00000450897.6 Q29709 ENST00000413696.5 H0Y4B8 ENST00000437583.5 ENST00000438510.5 ENST00000412948.6 A0A140T926 A0A140T987 A0A140T9F5 A0A140T9F6 ENST00000413038.5 A0A140T9Q5 ENST00000440269.5 ENST00000424874.5 A0A1V0E3N8 X5CKA5 ENST00000439344.6 A0A140T9E3 ENST00000449417.1 ENST00000456428.6 ENST00000448798.5 A0A140T9R0 ENST00000441177.5 A0A140T9K0 ENST00000435056.1 ENST00000451921.5 ENST00000430115.5 A0A140T9K4 A0A140T943 A0A140T9K9 ENST00000435204.5 A8CGH7 A0A140T9Q8 ENST00000424822.6 H0Y7A2 ENST00000437382.5 A8CGH9 A0A0G2JI43 ENST00000415090.1 ENST00000452407.6 ENST00000449679.1 A0A140T965 O02952 ENST00000433242.5 |