Name | Number of supported studies | Average coverage | |
---|---|---|---|
astrocyte | 14 studies | 36% ± 18% | |
endothelial cell | 14 studies | 38% ± 17% | |
glutamatergic neuron | 13 studies | 60% ± 21% | |
microglial cell | 13 studies | 51% ± 15% | |
fibroblast | 12 studies | 28% ± 12% | |
GABAergic neuron | 11 studies | 63% ± 25% | |
oligodendrocyte precursor cell | 11 studies | 26% ± 9% | |
oligodendrocyte | 11 studies | 32% ± 17% | |
adipocyte | 9 studies | 53% ± 8% | |
endothelial cell of lymphatic vessel | 7 studies | 39% ± 13% | |
neuron | 6 studies | 41% ± 17% | |
interneuron | 6 studies | 73% ± 18% | |
macrophage | 6 studies | 32% ± 12% | |
pericyte | 6 studies | 29% ± 17% | |
T cell | 6 studies | 23% ± 10% | |
amacrine cell | 5 studies | 35% ± 18% | |
cardiac muscle cell | 5 studies | 35% ± 9% | |
natural killer cell | 5 studies | 31% ± 9% | |
type I pneumocyte | 5 studies | 29% ± 7% | |
type II pneumocyte | 5 studies | 42% ± 9% | |
granule cell | 4 studies | 65% ± 9% | |
myeloid cell | 4 studies | 19% ± 2% | |
retina horizontal cell | 4 studies | 49% ± 13% | |
retinal ganglion cell | 4 studies | 27% ± 12% | |
club cell | 4 studies | 30% ± 6% | |
smooth muscle cell | 4 studies | 19% ± 3% | |
basal cell | 4 studies | 38% ± 19% | |
GABAergic interneuron | 3 studies | 70% ± 2% | |
epithelial cell | 3 studies | 30% ± 9% | |
mesothelial cell | 3 studies | 35% ± 9% | |
GABAergic amacrine cell | 3 studies | 53% ± 11% | |
Mueller cell | 3 studies | 40% ± 4% | |
glycinergic amacrine cell | 3 studies | 37% ± 6% | |
CD8-positive, alpha-beta T cell | 3 studies | 20% ± 4% | |
dendritic cell | 3 studies | 22% ± 2% | |
monocyte | 3 studies | 25% ± 2% | |
lymphocyte | 3 studies | 25% ± 6% | |
mucus secreting cell | 3 studies | 28% ± 2% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
breast | 100% | 1495.07 | 458 / 459 | 100% | 8.18 | 1115 / 1118 |
thymus | 100% | 1560.63 | 652 / 653 | 99% | 5.96 | 601 / 605 |
skin | 100% | 2465.87 | 1806 / 1809 | 97% | 8.41 | 460 / 472 |
prostate | 100% | 1284.05 | 244 / 245 | 97% | 3.72 | 485 / 502 |
brain | 97% | 1372.64 | 2562 / 2642 | 98% | 4.66 | 689 / 705 |
lung | 100% | 1760.22 | 578 / 578 | 92% | 3.93 | 1063 / 1155 |
esophagus | 93% | 792.05 | 1340 / 1445 | 96% | 6.85 | 175 / 183 |
adrenal gland | 98% | 602.41 | 254 / 258 | 88% | 2.52 | 203 / 230 |
uterus | 98% | 464.46 | 166 / 170 | 88% | 4.02 | 405 / 459 |
pancreas | 79% | 329.08 | 260 / 328 | 97% | 3.32 | 172 / 178 |
ovary | 96% | 452.89 | 173 / 180 | 77% | 2.05 | 333 / 430 |
intestine | 95% | 499.99 | 917 / 966 | 75% | 2.06 | 394 / 527 |
kidney | 96% | 549.01 | 85 / 89 | 74% | 2.20 | 663 / 901 |
stomach | 74% | 366.97 | 267 / 359 | 77% | 2.89 | 220 / 286 |
bladder | 81% | 483.19 | 17 / 21 | 69% | 2.30 | 349 / 504 |
spleen | 100% | 886.28 | 241 / 241 | 0% | 0 | 0 / 0 |
adipose | 99% | 1076.11 | 1197 / 1204 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 97% | 12.70 | 28 / 29 |
tonsil | 0% | 0 | 0 / 0 | 96% | 7.56 | 43 / 45 |
heart | 89% | 512.38 | 766 / 861 | 0% | 0 | 0 / 0 |
blood vessel | 82% | 375.58 | 1091 / 1335 | 0% | 0 | 0 / 0 |
liver | 42% | 138.04 | 94 / 226 | 31% | 0.77 | 125 / 406 |
peripheral blood | 57% | 748.00 | 531 / 929 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 56% | 1.21 | 45 / 80 |
muscle | 54% | 221.20 | 434 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0035914 | Biological process | skeletal muscle cell differentiation |
GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
GO_0005737 | Cellular component | cytoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0000978 | Molecular function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
GO_0005515 | Molecular function | protein binding |
GO_0000981 | Molecular function | DNA-binding transcription factor activity, RNA polymerase II-specific |
GO_0046872 | Molecular function | metal ion binding |
Gene name | HIVEP3 |
Protein name | Transcription factor HIVEP3 (Human immunodeficiency virus type I enhancer-binding protein 3) (Kappa-B and V(D)J recombination signal sequences-binding protein) (Kappa-binding protein 1) (KBP-1) (Zinc finger protein ZAS3) |
Synonyms | KIAA1555 KBP1 KRC ZAS3 |
Description | FUNCTION: Plays a role of transcription factor; binds to recognition signal sequences (Rss heptamer) for somatic recombination of immunoglobulin and T-cell receptor gene segments; Binds also to the kappa-B motif of gene such as S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regulatory element found in promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens, mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down-regulation promotes cell cycle progression with ultimate formation of multinucleated giant cells. Strongly inhibits TNF-alpha-induced NF-kappa-B activation; Interferes with nuclear factor NF-kappa-B by several mechanisms: as transcription factor, by competing for Kappa-B motif and by repressing transcription in the nucleus; through a non transcriptional process, by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in the tumor necrosis factor signaling, which blocks the formation of IKK complex. Interaction with TRAF proteins inhibits both NF-Kappa-B-mediated and c-Jun N-terminal kinase/JNK-mediated responses that include apoptosis and pro-inflammatory cytokine gene expression. Positively regulates the expression of IL2 in T-cell. Essential regulator of adult bone formation. . |
Accessions | ENST00000372583.6 [Q5T1R4-1] Q5T1R4 ENST00000372584.5 [Q5T1R4-2] ENST00000643665.1 [Q5T1R4-2] |