HACE1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0061025Biological processmembrane fusion
GO_0016567Biological processprotein ubiquitination
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0007030Biological processGolgi organization
GO_0070936Biological processprotein K48-linked ubiquitination
GO_0000209Biological processprotein polyubiquitination
GO_0030334Biological processregulation of cell migration
GO_0016601Biological processRac protein signal transduction
GO_0000139Cellular componentGolgi membrane
GO_0016604Cellular componentnuclear body
GO_0005783Cellular componentendoplasmic reticulum
GO_0032580Cellular componentGolgi cisterna membrane
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0005515Molecular functionprotein binding
GO_0031267Molecular functionsmall GTPase binding

IV. Literature review

[source]
Gene nameHACE1
Protein nameAlternative protein HACE1
HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1
E3 ubiquitin-protein ligase HACE1 (EC 2.3.2.26) (HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1) (HECT-type E3 ubiquitin transferase HACE1)
HECT-type E3 ubiquitin transferase (EC 2.3.2.26)
SynonymsKIAA1320
DescriptionFUNCTION: E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. May also act as a transcription regulator via its interaction with RARB. .

AccessionsENST00000262903.9 [Q8IYU2-1]
ENST00000521962.1
ENST00000416605.6
H0YAU8
H0YC48
ENST00000518503.5
E5RHI1
L8E8L5
ENST00000524020.1
ENST00000517424.1
Q8IYU2
ENST00000518402.5
ENST00000369125.6 [Q8IYU2-4]
H0YC01
E5RFX0
ENST00000519645.5
H0YBH3
E3W983