Name | Number of supported studies | Average coverage | |
---|---|---|---|
glutamatergic neuron | 9 studies | 44% ± 28% | |
endothelial cell | 8 studies | 31% ± 12% | |
oligodendrocyte precursor cell | 8 studies | 27% ± 12% | |
GABAergic neuron | 7 studies | 41% ± 23% | |
oligodendrocyte | 7 studies | 29% ± 10% | |
interneuron | 6 studies | 39% ± 22% | |
microglial cell | 6 studies | 27% ± 5% | |
astrocyte | 6 studies | 34% ± 14% | |
neuron | 4 studies | 28% ± 9% | |
macrophage | 4 studies | 22% ± 5% | |
granule cell | 3 studies | 19% ± 1% | |
retina horizontal cell | 3 studies | 30% ± 17% | |
retinal cone cell | 3 studies | 31% ± 11% | |
retinal rod cell | 3 studies | 31% ± 8% | |
endothelial cell of lymphatic vessel | 3 studies | 18% ± 2% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 100% | 1840.39 | 2642 / 2642 | 100% | 8.49 | 703 / 705 |
esophagus | 100% | 1092.44 | 1445 / 1445 | 99% | 5.97 | 182 / 183 |
lung | 100% | 1053.63 | 576 / 578 | 99% | 4.65 | 1147 / 1155 |
breast | 100% | 1320.05 | 459 / 459 | 98% | 5.48 | 1100 / 1118 |
ovary | 100% | 1329.52 | 180 / 180 | 97% | 3.59 | 418 / 430 |
prostate | 100% | 944.56 | 245 / 245 | 97% | 4.34 | 485 / 502 |
bladder | 100% | 1009.67 | 21 / 21 | 96% | 3.90 | 485 / 504 |
thymus | 100% | 967.71 | 652 / 653 | 96% | 4.08 | 579 / 605 |
uterus | 100% | 1586.04 | 170 / 170 | 95% | 4.66 | 438 / 459 |
intestine | 100% | 932.28 | 966 / 966 | 94% | 2.77 | 495 / 527 |
stomach | 98% | 600.55 | 352 / 359 | 96% | 3.52 | 274 / 286 |
skin | 100% | 990.76 | 1806 / 1809 | 92% | 4.06 | 435 / 472 |
adrenal gland | 100% | 682.64 | 258 / 258 | 91% | 3.69 | 209 / 230 |
kidney | 100% | 659.88 | 89 / 89 | 91% | 4.05 | 816 / 901 |
pancreas | 93% | 367.99 | 306 / 328 | 97% | 3.19 | 172 / 178 |
adipose | 100% | 1185.70 | 1204 / 1204 | 0% | 0 | 0 / 0 |
spleen | 100% | 648.74 | 241 / 241 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 1214.46 | 1334 / 1335 | 0% | 0 | 0 / 0 |
liver | 49% | 134.70 | 111 / 226 | 50% | 1.10 | 204 / 406 |
heart | 96% | 516.05 | 828 / 861 | 0% | 0 | 0 / 0 |
muscle | 96% | 422.30 | 768 / 803 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 93% | 4.04 | 42 / 45 |
lymph node | 0% | 0 | 0 / 0 | 69% | 1.74 | 20 / 29 |
eye | 0% | 0 | 0 / 0 | 64% | 1.73 | 51 / 80 |
peripheral blood | 30% | 256.58 | 280 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0061025 | Biological process | membrane fusion |
GO_0016567 | Biological process | protein ubiquitination |
GO_0006511 | Biological process | ubiquitin-dependent protein catabolic process |
GO_0007030 | Biological process | Golgi organization |
GO_0070936 | Biological process | protein K48-linked ubiquitination |
GO_0000209 | Biological process | protein polyubiquitination |
GO_0030334 | Biological process | regulation of cell migration |
GO_0016601 | Biological process | Rac protein signal transduction |
GO_0000139 | Cellular component | Golgi membrane |
GO_0016604 | Cellular component | nuclear body |
GO_0005783 | Cellular component | endoplasmic reticulum |
GO_0032580 | Cellular component | Golgi cisterna membrane |
GO_0005737 | Cellular component | cytoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0061630 | Molecular function | ubiquitin protein ligase activity |
GO_0004842 | Molecular function | ubiquitin-protein transferase activity |
GO_0005515 | Molecular function | protein binding |
GO_0031267 | Molecular function | small GTPase binding |
Gene name | HACE1 |
Protein name | Alternative protein HACE1 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 E3 ubiquitin-protein ligase HACE1 (EC 2.3.2.26) (HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1) (HECT-type E3 ubiquitin transferase HACE1) HECT-type E3 ubiquitin transferase (EC 2.3.2.26) |
Synonyms | KIAA1320 |
Description | FUNCTION: E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. May also act as a transcription regulator via its interaction with RARB. . |
Accessions | ENST00000262903.9 [Q8IYU2-1] ENST00000521962.1 ENST00000416605.6 H0YAU8 H0YC48 ENST00000518503.5 E5RHI1 L8E8L5 ENST00000524020.1 ENST00000517424.1 Q8IYU2 ENST00000518402.5 ENST00000369125.6 [Q8IYU2-4] H0YC01 E5RFX0 ENST00000519645.5 H0YBH3 E3W983 |