GRM5 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
oligodendrocyte precursor cell	15 studies	66% ± 19%	Explore
glutamatergic neuron	12 studies	77% ± 21%	Explore
GABAergic neuron	11 studies	63% ± 20%	Explore
astrocyte	7 studies	38% ± 19%	Explore
interneuron	6 studies	54% ± 26%	Explore
neuron	5 studies	41% ± 18%	Explore
endothelial cell	4 studies	46% ± 18%	Explore
microglial cell	4 studies	37% ± 18%	Explore
GABAergic interneuron	3 studies	78% ± 1%	Explore
GABAergic amacrine cell	3 studies	29% ± 9%	Explore
ON-bipolar cell	3 studies	57% ± 28%	Explore
rod bipolar cell	3 studies	73% ± 30%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	17 studies	44% ± 25%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	85%	184.54	2245 / 2642	44%	2.18	307 / 705
blood vessel	18%	6.67	234 / 1335	0%	0	0 / 0
kidney	0%	0	0 / 89	9%	0.18	81 / 901
lung	2%	0.86	14 / 578	0%	0.01	5 / 1155
liver	0%	0	0 / 226	2%	0.04	9 / 406
skin	0%	0.06	1 / 1809	1%	0.01	3 / 472
pancreas	0%	0	0 / 328	1%	0.01	1 / 178
adrenal gland	0%	0	0 / 258	0%	0.00	1 / 230
muscle	0%	0.06	2 / 803	0%	0	0 / 0
breast	0%	0	0 / 459	0%	0.00	2 / 1118
adipose	0%	0.05	2 / 1204	0%	0	0 / 0
thymus	0%	0.04	1 / 653	0%	0	0 / 605
abdomen	0%	0	0 / 0	0%	0	0 / 0
bladder	0%	0	0 / 21	0%	0	0 / 504
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
esophagus	0%	0	0 / 1445	0%	0	0 / 183
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
heart	0%	0	0 / 861	0%	0	0 / 0
intestine	0%	0	0 / 966	0%	0	0 / 527
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
ovary	0%	0	0 / 180	0%	0	0 / 430
peripheral blood	0%	0	0 / 929	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
prostate	0%	0	0 / 245	0%	0	0 / 502
spinal column	0%	0	0 / 0	0%	0	0 / 0
spleen	0%	0	0 / 241	0%	0	0 / 0
stomach	0%	0	0 / 359	0%	0	0 / 286
tonsil	0%	0	0 / 0	0%	0	0 / 45
ureter	0%	0	0 / 0	0%	0	0 / 1
uterus	0%	0	0 / 170	0%	0	0 / 459

III. Associated gene sets

GO_0048170	Biological process	positive regulation of long-term neuronal synaptic plasticity
GO_0050850	Biological process	positive regulation of calcium-mediated signaling
GO_0099566	Biological process	regulation of postsynaptic cytosolic calcium ion concentration
GO_0002029	Biological process	desensitization of G protein-coupled receptor signaling pathway
GO_0007612	Biological process	learning
GO_0007611	Biological process	learning or memory
GO_0007206	Biological process	phospholipase C-activating G protein-coupled glutamate receptor signaling pathway
GO_0007196	Biological process	adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway
GO_0099553	Biological process	trans-synaptic signaling by endocannabinoid, modulating synaptic transmission
GO_0007216	Biological process	G protein-coupled glutamate receptor signaling pathway
GO_0043410	Biological process	positive regulation of MAPK cascade
GO_0051966	Biological process	regulation of synaptic transmission, glutamatergic
GO_0007268	Biological process	chemical synaptic transmission
GO_0006355	Biological process	regulation of DNA-templated transcription
GO_0060078	Biological process	regulation of postsynaptic membrane potential
GO_0050890	Biological process	cognition
GO_0050808	Biological process	synapse organization
GO_1904646	Biological process	cellular response to amyloid-beta
GO_0007626	Biological process	locomotory behavior
GO_0007205	Biological process	protein kinase C-activating G protein-coupled receptor signaling pathway
GO_0098978	Cellular component	glutamatergic synapse
GO_0098839	Cellular component	postsynaptic density membrane
GO_0098685	Cellular component	Schaffer collateral - CA1 synapse
GO_0005886	Cellular component	plasma membrane
GO_0043197	Cellular component	dendritic spine
GO_0043198	Cellular component	dendritic shaft
GO_0030425	Cellular component	dendrite
GO_0097449	Cellular component	astrocyte projection
GO_0005737	Cellular component	cytoplasm
GO_0008066	Molecular function	glutamate receptor activity
GO_0004930	Molecular function	G protein-coupled receptor activity
GO_0031687	Molecular function	A2A adenosine receptor binding
GO_0099583	Molecular function	neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration
GO_0042802	Molecular function	identical protein binding
GO_1990782	Molecular function	protein tyrosine kinase binding
GO_0099530	Molecular function	G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential
GO_0030296	Molecular function	protein tyrosine kinase activator activity
GO_0001640	Molecular function	adenylate cyclase inhibiting G protein-coupled glutamate receptor activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	GRM5
Protein name	Metabotropic glutamate receptor 5 variant H Metabotropic glutamate receptor 5 variant G Metabotropic glutamate receptor 5 variant F GRM5 variant 9 Glutamate metabotropic receptor 5 Metabotropic glutamate receptor 5 (mGluR5)
Synonyms	MGLUR5 GPRC1E
Description	FUNCTION: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity. .
Accessions	G8XUU6 K9J9K9 A8MT20 ENST00000305432.9 [P41594-2] G8XUU8 P41594 ENST00000305447.5 [P41594-1] ENST00000393294.3 ENST00000455756.6 [P41594-2] G8XUU7 ENST00000449371.6 H7C223

GRM5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review