Insufficient scRNA-seq data for expression of GRM2 at single-cell level.
Insufficient scRNA-seq data for expression of GRM2 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 92% | 623.51 | 2419 / 2642 | 48% | 1.81 | 339 / 705 |
spleen | 98% | 174.56 | 236 / 241 | 0% | 0 | 0 / 0 |
breast | 70% | 82.63 | 321 / 459 | 5% | 0.10 | 51 / 1118 |
skin | 65% | 176.93 | 1180 / 1809 | 2% | 0.06 | 9 / 472 |
muscle | 67% | 90.80 | 539 / 803 | 0% | 0 | 0 / 0 |
uterus | 51% | 38.96 | 86 / 170 | 10% | 0.24 | 44 / 459 |
adipose | 60% | 91.62 | 717 / 1204 | 0% | 0 | 0 / 0 |
thymus | 53% | 51.94 | 345 / 653 | 1% | 0.01 | 4 / 605 |
prostate | 51% | 42.36 | 124 / 245 | 1% | 0.01 | 4 / 502 |
bladder | 43% | 52.24 | 9 / 21 | 4% | 0.09 | 22 / 504 |
lung | 43% | 40.82 | 251 / 578 | 3% | 0.05 | 29 / 1155 |
intestine | 42% | 34.92 | 401 / 966 | 2% | 0.03 | 10 / 527 |
blood vessel | 41% | 41.22 | 548 / 1335 | 0% | 0 | 0 / 0 |
ovary | 26% | 18.12 | 47 / 180 | 10% | 0.38 | 44 / 430 |
heart | 35% | 29.69 | 298 / 861 | 0% | 0 | 0 / 0 |
kidney | 28% | 25.37 | 25 / 89 | 2% | 0.03 | 17 / 901 |
esophagus | 23% | 16.83 | 332 / 1445 | 6% | 0.09 | 11 / 183 |
stomach | 20% | 14.64 | 71 / 359 | 5% | 0.08 | 13 / 286 |
pancreas | 15% | 10.37 | 49 / 328 | 7% | 0.19 | 13 / 178 |
peripheral blood | 13% | 11.73 | 125 / 929 | 0% | 0 | 0 / 0 |
adrenal gland | 4% | 2.54 | 11 / 258 | 5% | 0.14 | 12 / 230 |
liver | 5% | 3.36 | 12 / 226 | 2% | 0.05 | 8 / 406 |
tonsil | 0% | 0 | 0 / 0 | 2% | 0.02 | 1 / 45 |
eye | 0% | 0 | 0 / 0 | 1% | 0.03 | 1 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0014059 | Biological process | regulation of dopamine secretion |
GO_0007194 | Biological process | negative regulation of adenylate cyclase activity |
GO_2001023 | Biological process | regulation of response to drug |
GO_0090461 | Biological process | intracellular glutamate homeostasis |
GO_0007196 | Biological process | adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway |
GO_0035095 | Biological process | behavioral response to nicotine |
GO_0014048 | Biological process | regulation of glutamate secretion |
GO_0007216 | Biological process | G protein-coupled glutamate receptor signaling pathway |
GO_0051966 | Biological process | regulation of synaptic transmission, glutamatergic |
GO_0060292 | Biological process | long-term synaptic depression |
GO_0042220 | Biological process | response to cocaine |
GO_0007268 | Biological process | chemical synaptic transmission |
GO_0099171 | Biological process | presynaptic modulation of chemical synaptic transmission |
GO_0051897 | Biological process | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
GO_0010467 | Biological process | gene expression |
GO_0014047 | Biological process | glutamate secretion |
GO_0098978 | Cellular component | glutamatergic synapse |
GO_0005886 | Cellular component | plasma membrane |
GO_0042734 | Cellular component | presynaptic membrane |
GO_0030425 | Cellular component | dendrite |
GO_0097449 | Cellular component | astrocyte projection |
GO_0030424 | Cellular component | axon |
GO_0001641 | Molecular function | group II metabotropic glutamate receptor activity |
GO_0008066 | Molecular function | glutamate receptor activity |
GO_0004930 | Molecular function | G protein-coupled receptor activity |
GO_0005246 | Molecular function | calcium channel regulator activity |
GO_0097110 | Molecular function | scaffold protein binding |
GO_0005515 | Molecular function | protein binding |
Gene name | GRM2 |
Protein name | Glutamate metabotropic receptor 2 Metabotropic glutamate receptor 2 (mGluR2) |
Synonyms | GPRC1B MGLUR2 |
Description | FUNCTION: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization. . |
Accessions | ENST00000419928.1 C9JD41 ENST00000442933.2 ENST00000296479.9 C9JL63 H7BXL3 Q14416 ENST00000395052.8 |