I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| GABAergic neuron | 6 studies | 38% ± 17% | |
| GABAergic interneuron | 3 studies | 19% ± 2% | |
| interneuron | 3 studies | 43% ± 13% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| GABAergic neuron | 6 studies | 38% ± 17% | |
| GABAergic interneuron | 3 studies | 19% ± 2% | |
| interneuron | 3 studies | 43% ± 13% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 3 studies | 22% ± 1% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 99% | 460.29 | 2612 / 2642 | 87% | 8.02 | 615 / 705 |
| skin | 98% | 334.93 | 1776 / 1809 | 57% | 6.13 | 268 / 472 |
| bladder | 67% | 45.00 | 14 / 21 | 70% | 16.73 | 352 / 504 |
| intestine | 42% | 31.45 | 405 / 966 | 92% | 27.05 | 486 / 527 |
| lung | 76% | 75.18 | 438 / 578 | 48% | 8.95 | 559 / 1155 |
| esophagus | 37% | 29.00 | 534 / 1445 | 86% | 29.38 | 157 / 183 |
| stomach | 25% | 20.33 | 90 / 359 | 89% | 29.00 | 255 / 286 |
| breast | 83% | 93.83 | 381 / 459 | 28% | 2.20 | 316 / 1118 |
| thymus | 100% | 224.92 | 651 / 653 | 8% | 0.49 | 49 / 605 |
| ovary | 53% | 62.78 | 96 / 180 | 47% | 5.26 | 203 / 430 |
| ureter | 0% | 0 | 0 / 0 | 100% | 19.24 | 1 / 1 |
| adrenal gland | 87% | 83.72 | 225 / 258 | 11% | 1.94 | 26 / 230 |
| adipose | 93% | 153.58 | 1123 / 1204 | 0% | 0 | 0 / 0 |
| pancreas | 16% | 11.52 | 51 / 328 | 74% | 12.16 | 131 / 178 |
| uterus | 28% | 24.79 | 47 / 170 | 59% | 10.56 | 273 / 459 |
| prostate | 78% | 93.92 | 191 / 245 | 6% | 0.30 | 32 / 502 |
| spleen | 76% | 64.07 | 184 / 241 | 0% | 0 | 0 / 0 |
| blood vessel | 66% | 66.75 | 879 / 1335 | 0% | 0 | 0 / 0 |
| heart | 53% | 51.27 | 458 / 861 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 42% | 5.74 | 19 / 45 |
| kidney | 35% | 25.00 | 31 / 89 | 5% | 0.38 | 45 / 901 |
| peripheral blood | 28% | 21.44 | 259 / 929 | 0% | 0 | 0 / 0 |
| liver | 20% | 17.01 | 45 / 226 | 6% | 0.40 | 24 / 406 |
| lymph node | 0% | 0 | 0 / 0 | 24% | 1.11 | 7 / 29 |
| eye | 0% | 0 | 0 / 0 | 8% | 0.30 | 6 / 80 |
| muscle | 4% | 2.25 | 29 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0097553 | Biological process | calcium ion transmembrane import into cytosol |
| GO_0019722 | Biological process | calcium-mediated signaling |
| GO_0060079 | Biological process | excitatory postsynaptic potential |
| GO_0008344 | Biological process | adult locomotory behavior |
| GO_0035235 | Biological process | ionotropic glutamate receptor signaling pathway |
| GO_0051930 | Biological process | regulation of sensory perception of pain |
| GO_0098976 | Biological process | excitatory chemical synaptic transmission |
| GO_0060291 | Biological process | long-term synaptic potentiation |
| GO_2000463 | Biological process | positive regulation of excitatory postsynaptic potential |
| GO_0099505 | Biological process | regulation of presynaptic membrane potential |
| GO_0048167 | Biological process | regulation of synaptic plasticity |
| GO_1904062 | Biological process | regulation of monoatomic cation transmembrane transport |
| GO_0048168 | Biological process | regulation of neuronal synaptic plasticity |
| GO_0098655 | Biological process | monoatomic cation transmembrane transport |
| GO_0007420 | Biological process | brain development |
| GO_0001964 | Biological process | startle response |
| GO_0051968 | Biological process | positive regulation of synaptic transmission, glutamatergic |
| GO_1905232 | Biological process | cellular response to L-glutamate |
| GO_0035249 | Biological process | synaptic transmission, glutamatergic |
| GO_0098978 | Cellular component | glutamatergic synapse |
| GO_0098839 | Cellular component | postsynaptic density membrane |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0005789 | Cellular component | endoplasmic reticulum membrane |
| GO_0048787 | Cellular component | presynaptic active zone membrane |
| GO_0098686 | Cellular component | hippocampal mossy fiber to CA3 synapse |
| GO_0045211 | Cellular component | postsynaptic membrane |
| GO_0017146 | Cellular component | NMDA selective glutamate receptor complex |
| GO_0022843 | Molecular function | voltage-gated monoatomic cation channel activity |
| GO_1904315 | Molecular function | transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential |
| GO_0004972 | Molecular function | NMDA glutamate receptor activity |
| GO_0004970 | Molecular function | glutamate-gated receptor activity |
| GO_0016595 | Molecular function | glutamate binding |
| GO_0099507 | Molecular function | ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential |
| GO_0022849 | Molecular function | glutamate-gated calcium ion channel activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | GRIN2D |
| Protein name | Glutamate receptor ionotropic, NMDA 2D (GluN2D) (EB11) (Glutamate [NMDA] receptor subunit epsilon-4) (N-methyl D-aspartate receptor subtype 2D) (NMDAR2D) (NR2D) |
| Synonyms | NMDAR2D GluN2D |
| Description | FUNCTION: Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) . Sensitivity to glutamate and channel kinetics depend on the subunit composition . . |
| Accessions | O15399 ENST00000263269.4 |
