GRIN2A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0019233Biological processsensory perception of pain
GO_0042177Biological processnegative regulation of protein catabolic process
GO_0097553Biological processcalcium ion transmembrane import into cytosol
GO_0019722Biological processcalcium-mediated signaling
GO_1903539Biological processprotein localization to postsynaptic membrane
GO_0007611Biological processlearning or memory
GO_0030431Biological processsleep
GO_0060079Biological processexcitatory postsynaptic potential
GO_0035235Biological processionotropic glutamate receptor signaling pathway
GO_0042417Biological processdopamine metabolic process
GO_0098976Biological processexcitatory chemical synaptic transmission
GO_0060291Biological processlong-term synaptic potentiation
GO_0045471Biological processresponse to ethanol
GO_0033058Biological processdirectional locomotion
GO_2000463Biological processpositive regulation of excitatory postsynaptic potential
GO_0008542Biological processvisual learning
GO_0097202Biological processactivation of cysteine-type endopeptidase activity
GO_0048167Biological processregulation of synaptic plasticity
GO_1904062Biological processregulation of monoatomic cation transmembrane transport
GO_0022008Biological processneurogenesis
GO_0048168Biological processregulation of neuronal synaptic plasticity
GO_0007268Biological processchemical synaptic transmission
GO_0098655Biological processmonoatomic cation transmembrane transport
GO_0030163Biological processprotein catabolic process
GO_0007420Biological processbrain development
GO_0007613Biological processmemory
GO_0001964Biological processstartle response
GO_0051968Biological processpositive regulation of synaptic transmission, glutamatergic
GO_0001975Biological processresponse to amphetamine
GO_0009410Biological processresponse to xenobiotic stimulus
GO_0042428Biological processserotonin metabolic process
GO_0007215Biological processglutamate receptor signaling pathway
GO_0043065Biological processpositive regulation of apoptotic process
GO_0009611Biological processresponse to wounding
GO_1904646Biological processcellular response to amyloid-beta
GO_0035249Biological processsynaptic transmission, glutamatergic
GO_0098978Cellular componentglutamatergic synapse
GO_0098839Cellular componentpostsynaptic density membrane
GO_0005886Cellular componentplasma membrane
GO_0043197Cellular componentdendritic spine
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0097060Cellular componentsynaptic membrane
GO_0042734Cellular componentpresynaptic membrane
GO_0009986Cellular componentcell surface
GO_0008021Cellular componentsynaptic vesicle
GO_0014069Cellular componentpostsynaptic density
GO_0045211Cellular componentpostsynaptic membrane
GO_0017146Cellular componentNMDA selective glutamate receptor complex
GO_0030659Cellular componentcytoplasmic vesicle membrane
GO_1904315Molecular functiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
GO_0004972Molecular functionNMDA glutamate receptor activity
GO_0001540Molecular functionamyloid-beta binding
GO_0008270Molecular functionzinc ion binding
GO_0022849Molecular functionglutamate-gated calcium ion channel activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameGRIN2A
Protein nameGlutamate receptor
Glutamate ionotropic receptor NMDA type subunit 2A
Glutamate receptor ionotropic, NMDA 2A (GluN2A) (Glutamate [NMDA] receptor subunit epsilon-1) (N-methyl D-aspartate receptor subtype 2A) (NMDAR2A) (NR2A) (hNR2A)
SynonymsNR2A
NMDAR2A
hCG_14641
DescriptionFUNCTION: Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) . Sensitivity to glutamate and channel kinetics depend on the subunit composition; channels containing GRIN1 and GRIN2A have lower sensitivity to glutamate and faster deactivation kinetics than channels formed by GRIN1 and GRIN2B . Contributes to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning (By similarity). .

FUNCTION: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. .

FUNCTION: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. .

FUNCTION: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. .

FUNCTION: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. .

FUNCTION: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. .

AccessionsA0A890YTL4
A0A1B0GUT1
ENST00000674742.1
A0A6Q8PGD2
ENST00000330684.4 [Q12879-1]
ENST00000562109.5 [Q12879-2]
A0A1B0GU35
Q12879
ENST00000637393.1
ENST00000396573.6 [Q12879-1]
ENST00000637188.1
ENST00000535259.6
A0A6Q8PHM7
ENST00000675398.1
ENST00000636406.1
F5GZ52
Q547U9
A0A1B0GVW1