GRHL2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030216Biological processkeratinocyte differentiation
GO_0061713Biological processanterior neural tube closure
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0060672Biological processepithelial cell morphogenesis involved in placental branching
GO_0042733Biological processembryonic digit morphogenesis
GO_0003382Biological processepithelial cell morphogenesis
GO_0035264Biological processmulticellular organism growth
GO_0007155Biological processcell adhesion
GO_0090132Biological processepithelium migration
GO_0003208Biological processcardiac ventricle morphogenesis
GO_0060463Biological processlung lobe morphogenesis
GO_0060324Biological processface development
GO_0070830Biological processbicellular tight junction assembly
GO_0051973Biological processpositive regulation of telomerase activity
GO_0001843Biological processneural tube closure
GO_0034329Biological processcell junction assembly
GO_0048701Biological processembryonic cranial skeleton morphogenesis
GO_0007420Biological processbrain development
GO_0043010Biological processcamera-type eye development
GO_0021915Biological processneural tube development
GO_0060487Biological processlung epithelial cell differentiation
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0016020Cellular componentmembrane
GO_0005654Cellular componentnucleoplasm
GO_0005911Cellular componentcell-cell junction
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0140297Molecular functionDNA-binding transcription factor binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0043565Molecular functionsequence-specific DNA binding
GO_0001161Molecular functionintronic transcription regulatory region sequence-specific DNA binding
GO_0042802Molecular functionidentical protein binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0001216Molecular functionDNA-binding transcription activator activity
GO_0031490Molecular functionchromatin DNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameGRHL2
Protein nameGrainyhead-like protein 2 homolog (Brother of mammalian grainyhead) (Transcription factor CP2-like 3)
SynonymsBOM
TFCP2L3
DescriptionFUNCTION: Transcription factor playing an important role in primary neurulation and in epithelial development . Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' acting as an activator and repressor on distinct target genes (By similarity). During embryogenesis, plays unique and cooperative roles with GRHL3 in establishing distinct zones of primary neurulation. Essential for closure 3 (rostral end of the forebrain), functions cooperatively with GRHL3 in closure 2 (forebrain/midbrain boundary) and posterior neuropore closure (By similarity). Regulates epithelial morphogenesis acting as a target gene-associated transcriptional activator of apical junctional complex components. Up-regulates of CLDN3 and CLDN4, as well as of RAB25, which increases the CLDN4 protein and its localization at tight junctions (By similarity). Comprises an essential component of the transcriptional machinery that establishes appropriate expression levels of CLDN4 and CDH1 in different types of epithelia. Exhibits functional redundancy with GRHL3 in epidermal morphogenetic events and epidermal wound repair (By similarity). In lung, forms a regulatory loop with NKX2-1 that coordinates lung epithelial cell morphogenesis and differentiation (By similarity). In keratinocytes, plays a role in telomerase activation during cellular proliferation, regulates TERT expression by binding to TERT promoter region and inhibiting DNA methylation at the 5'-CpG island, possibly by interfering with DNMT1 enzyme activity . In addition, impairs keratinocyte differentiation and epidermal function by inhibiting the expression of genes clustered at the epidermal differentiation complex (EDC) as well as GRHL1 and GRHL3 through epigenetic mechanisms . .

AccessionsENST00000646743.1 [Q6ISB3-1]
Q6ISB3
ENST00000395927.1 [Q6ISB3-2]