GPR37L1 | OmnibusX

Name	Number of supported studies	Average coverage
astrocyte	15 studies	36% ± 10%	Explore
oligodendrocyte precursor cell	11 studies	40% ± 16%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of GPR37L1 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	9305.84	2634 / 2642	100%	150.93	702 / 705
ovary	0%	0	0 / 180	50%	1.56	214 / 430
intestine	4%	44.23	36 / 966	37%	0.81	196 / 527
stomach	1%	5.06	2 / 359	37%	0.63	105 / 286
adrenal gland	0%	3.43	1 / 258	33%	0.92	75 / 230
esophagus	2%	18.15	22 / 1445	25%	0.56	45 / 183
breast	0%	1.69	1 / 459	17%	0.59	187 / 1118
bladder	0%	0	0 / 21	16%	0.27	80 / 504
pancreas	0%	0	0 / 328	16%	0.31	28 / 178
lung	0%	0	0 / 578	11%	0.27	128 / 1155
uterus	0%	0	0 / 170	9%	0.20	43 / 459
eye	0%	0	0 / 0	8%	0.32	6 / 80
skin	0%	0	0 / 1809	6%	0.32	26 / 472
liver	0%	0	0 / 226	5%	0.10	19 / 406
thymus	0%	0	0 / 653	3%	0.24	21 / 605
tonsil	0%	0	0 / 0	2%	0.03	1 / 45
kidney	0%	0	0 / 89	2%	0.03	15 / 901
prostate	1%	7.56	2 / 245	1%	0.01	3 / 502
adipose	0%	2.15	3 / 1204	0%	0	0 / 0
blood vessel	0%	2.04	3 / 1335	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
heart	0%	0	0 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
muscle	0%	0	0 / 803	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
peripheral blood	0%	0	0 / 929	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
spleen	0%	0	0 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0007224	Biological process	smoothened signaling pathway
GO_0034614	Biological process	cellular response to reactive oxygen species
GO_0060020	Biological process	Bergmann glial cell differentiation
GO_0045879	Biological process	negative regulation of smoothened signaling pathway
GO_0043410	Biological process	positive regulation of MAPK cascade
GO_0048712	Biological process	negative regulation of astrocyte differentiation
GO_0003085	Biological process	negative regulation of systemic arterial blood pressure
GO_0045665	Biological process	negative regulation of neuron differentiation
GO_0007193	Biological process	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
GO_0021940	Biological process	positive regulation of cerebellar granule cell precursor proliferation
GO_0043235	Cellular component	receptor complex
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0060170	Cellular component	ciliary membrane
GO_0004930	Molecular function	G protein-coupled receptor activity
GO_0042277	Molecular function	peptide binding
GO_0008528	Molecular function	G protein-coupled peptide receptor activity
GO_0036505	Molecular function	prosaposin receptor activity
GO_0005515	Molecular function	protein binding

Gene name	GPR37L1
Protein name	G protein-coupled receptor 37 like 1 G-protein coupled receptor 37-like 1 (Endothelin B receptor-like protein 2) (ETBR-LP-2)
Synonyms	ETBRLP2
Description	FUNCTION: G-protein coupled receptor . Has been shown to bind the neuroprotective and glioprotective factor prosaposin (PSAP), leading to endocytosis followed by an ERK phosphorylation cascade . However, other studies have shown that prosaposin does not increase activity . It has been suggested that GPR37L1 is a constitutively active receptor which signals through the guanine nucleotide-binding protein G(s) subunit alpha . Participates in the regulation of postnatal cerebellar development by modulating the Shh pathway (By similarity). Regulates baseline blood pressure in females and protects against cardiovascular stress in males (By similarity). Mediates inhibition of astrocyte glutamate transporters and reduction in neuronal N-methyl-D-aspartate receptor activity (By similarity). .
Accessions	ENST00000367282.6 ENST00000682887.1 A0A804HLL0 ENST00000682545.1 ENST00000683557.1 O60883 A0A804HKD8 A0A804HI82 A0A804HKQ6 ENST00000683302.1

GPR37L1 report