GNPTAB | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	36 studies	33% ± 11%	Explore
mast cell	26 studies	37% ± 13%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	39% ± 11%	Explore
oligodendrocyte precursor cell	15 studies	39% ± 21%	Explore
macrophage	14 studies	24% ± 9%	Explore
mature NK T cell	13 studies	26% ± 9%	Explore
CD16-negative, CD56-bright natural killer cell, human	12 studies	27% ± 6%	Explore
glutamatergic neuron	11 studies	40% ± 24%	Explore
gamma-delta T cell	11 studies	26% ± 7%	Explore
CD8-positive, alpha-beta T cell	9 studies	21% ± 5%	Explore
astrocyte	9 studies	32% ± 17%	Explore
type I pneumocyte	8 studies	24% ± 6%	Explore
GABAergic neuron	8 studies	44% ± 20%	Explore
microglial cell	8 studies	25% ± 6%	Explore
B cell	7 studies	21% ± 5%	Explore
T cell	7 studies	21% ± 5%	Explore
effector memory CD8-positive, alpha-beta T cell	7 studies	21% ± 3%	Explore
endothelial cell	7 studies	26% ± 11%	Explore
epithelial cell	7 studies	27% ± 9%	Explore
CD8-positive, alpha-beta memory T cell	6 studies	19% ± 3%	Explore
myeloid cell	6 studies	27% ± 8%	Explore
type II pneumocyte	6 studies	25% ± 7%	Explore
interneuron	6 studies	41% ± 21%	Explore
neuron	5 studies	28% ± 6%	Explore
club cell	5 studies	26% ± 9%	Explore
basal cell	5 studies	21% ± 5%	Explore
dendritic cell	5 studies	29% ± 12%	Explore
monocyte	5 studies	22% ± 4%	Explore
leukocyte	4 studies	27% ± 8%	Explore
cardiac muscle cell	4 studies	25% ± 3%	Explore
lymphocyte	4 studies	37% ± 13%	Explore
respiratory goblet cell	4 studies	31% ± 14%	Explore
fibroblast	4 studies	17% ± 1%	Explore
melanocyte	4 studies	42% ± 26%	Explore
plasmacytoid dendritic cell	4 studies	24% ± 7%	Explore
ionocyte	3 studies	22% ± 3%	Explore
secretory cell	3 studies	17% ± 1%	Explore
effector CD8-positive, alpha-beta T cell	3 studies	21% ± 2%	Explore
classical monocyte	3 studies	25% ± 4%	Explore
conventional dendritic cell	3 studies	25% ± 7%	Explore
hematopoietic precursor cell	3 studies	33% ± 8%	Explore
non-classical monocyte	3 studies	23% ± 7%	Explore
GABAergic interneuron	3 studies	30% ± 6%	Explore
innate lymphoid cell	3 studies	23% ± 5%	Explore
granulocyte	3 studies	33% ± 13%	Explore
alveolar macrophage	3 studies	23% ± 7%	Explore
oligodendrocyte	3 studies	24% ± 8%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	14 studies	32% ± 19%	Explore
lung	6 studies	20% ± 4%	Explore
peripheral blood	4 studies	26% ± 6%	Explore
intestine	3 studies	17% ± 1%	Explore
liver	3 studies	18% ± 4%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	100%	3648.12	578 / 578	100%	27.13	1154 / 1155
brain	100%	3666.67	2642 / 2642	100%	22.66	704 / 705
esophagus	100%	2903.22	1445 / 1445	99%	23.26	182 / 183
breast	100%	2838.75	459 / 459	99%	27.75	1111 / 1118
thymus	100%	2408.49	653 / 653	99%	20.89	601 / 605
bladder	100%	2987.71	21 / 21	99%	21.70	500 / 504
intestine	100%	3426.99	966 / 966	99%	19.43	521 / 527
kidney	100%	2110.99	89 / 89	99%	21.16	890 / 901
skin	100%	3718.54	1809 / 1809	99%	54.72	466 / 472
uterus	100%	2209.66	170 / 170	98%	22.97	452 / 459
stomach	100%	2301.09	359 / 359	98%	19.72	281 / 286
prostate	100%	4122.31	245 / 245	98%	31.35	491 / 502
pancreas	98%	1410.42	323 / 328	98%	16.96	175 / 178
ovary	100%	1459.41	180 / 180	92%	12.75	396 / 430
adrenal gland	98%	1508.74	254 / 258	87%	12.36	199 / 230
liver	84%	694.74	189 / 226	61%	6.17	247 / 406
adipose	100%	2697.40	1204 / 1204	0%	0	0 / 0
spleen	100%	3103.25	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	30.24	45 / 45
ureter	0%	0	0 / 0	100%	15.68	1 / 1
blood vessel	100%	2577.94	1334 / 1335	0%	0	0 / 0
muscle	100%	1786.43	802 / 803	0%	0	0 / 0
heart	98%	2254.65	843 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	97%	23.04	28 / 29
eye	0%	0	0 / 0	95%	42.06	76 / 80
peripheral blood	90%	2555.75	836 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0007040	Biological process	lysosome organization
GO_0033299	Biological process	secretion of lysosomal enzymes
GO_0046835	Biological process	carbohydrate phosphorylation
GO_0016256	Biological process	N-glycan processing to lysosome
GO_0000139	Cellular component	Golgi membrane
GO_0005794	Cellular component	Golgi apparatus
GO_0005509	Molecular function	calcium ion binding
GO_0005515	Molecular function	protein binding
GO_0003976	Molecular function	UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity

IV. Literature review

[source]

Gene name	GNPTAB
Protein name	N-acetylglucosamine-1-phosphate transferase subunits alpha and beta GNPTAB protein (N-acetylglucosamine-1-phosphate transferase subunits alpha and beta) N-acetylglucosamine-1-phosphotransferase subunits alpha/beta (EC 2.7.8.17) (GlcNAc-1-phosphotransferase subunits alpha/beta) (Stealth protein GNPTAB) (UDP-N-acetylglucosamine-1-phosphotransferase subunits alpha/beta) [Cleaved into: N-acetylglucosamine-1-phosphotransferase subunit alpha; N-acetylglucosamine-1-phosphotransferase subunit beta]
Synonyms	GNPTA KIAA1208
Description	FUNCTION: Catalyzes the formation of mannose 6-phosphate (M6P) markers on high mannose type oligosaccharides in the Golgi apparatus. M6P residues are required to bind to the M6P receptors (MPR), which mediate the vesicular transport of lysosomal enzymes to the endosomal/prelysosomal compartment. .
Accessions	ENST00000392919.4 Q3T906 H0YIE6 H0YIU2 F8VQW2 ENST00000549940.5 [Q3T906-2] ENST00000549738.5 H0YIK3 ENST00000550718.1 ENST00000299314.12 [Q3T906-1] ENST00000552681.1 Q9BUA5 ENST00000549165.1

GNPTAB report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review