GGA2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006886Biological processintracellular protein transport
GO_0043001Biological processGolgi to plasma membrane protein transport
GO_0034394Biological processprotein localization to cell surface
GO_0006893Biological processGolgi to plasma membrane transport
GO_0005802Cellular componenttrans-Golgi network
GO_0010008Cellular componentendosome membrane
GO_0031901Cellular componentearly endosome membrane
GO_0030136Cellular componentclathrin-coated vesicle
GO_0005794Cellular componentGolgi apparatus
GO_0043130Molecular functionubiquitin binding
GO_0005515Molecular functionprotein binding
GO_0031267Molecular functionsmall GTPase binding
GO_0035091Molecular functionphosphatidylinositol binding

IV. Literature review

[source]
Gene nameGGA2
Protein nameADP-ribosylation factor-binding protein GGA2 (Gamma-adaptin-related protein 2) (Golgi-localized, gamma ear-containing, ARF-binding protein 2) (VHS domain and ear domain of gamma-adaptin) (Vear)
Golgi associated, gamma adaptin ear containing, ARF binding protein 2
SynonymsKIAA1080
DescriptionFUNCTION: Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif . Mediates export of the GPCR receptor ADRA2B to the cell surface . Regulates retrograde transport of phosphorylated form of BACE1 from endosomes to the trans-Golgi network . .

AccessionsH3BMM6
H3BPF4
I3L263
I3L2C4
Q9UJY4
ENST00000570111.5
H3BPI3
H3BMN6
ENST00000563047.1
ENST00000562944.5
ENST00000569300.5
ENST00000562117.1
ENST00000567468.5
ENST00000563494.5
ENST00000569189.2
ENST00000309859.8