GGA1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006886Biological processintracellular protein transport
GO_0034394Biological processprotein localization to cell surface
GO_0042147Biological processretrograde transport, endosome to Golgi
GO_0045732Biological processpositive regulation of protein catabolic process
GO_0006893Biological processGolgi to plasma membrane transport
GO_0030163Biological processprotein catabolic process
GO_0008104Biological processprotein localization
GO_0043001Biological processGolgi to plasma membrane protein transport
GO_1903441Biological processprotein localization to ciliary membrane
GO_0016020Cellular componentmembrane
GO_0005769Cellular componentearly endosome
GO_0031901Cellular componentearly endosome membrane
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0005794Cellular componentGolgi apparatus
GO_0005802Cellular componenttrans-Golgi network
GO_0005829Cellular componentcytosol
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0010008Cellular componentendosome membrane
GO_0031267Molecular functionsmall GTPase binding
GO_0035091Molecular functionphosphatidylinositol binding
GO_0005515Molecular functionprotein binding
GO_0043130Molecular functionubiquitin binding
GO_0003674Molecular functionmolecular_function

IV. Literature review

[source]
Gene nameGGA1
Protein nameADP-ribosylation factor-binding protein GGA1 (Gamma-adaptin-related protein 1) (Golgi-localized, gamma ear-containing, ARF-binding protein 1)
Golgi associated, gamma adaptin ear containing, ARF binding protein 1
Synonyms
DescriptionFUNCTION: Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif . Mediates export of the GPCR receptor ADRA2B to the cell surface . Required for targeting PKD1:PKD2 complex from the trans-Golgi network to the cilium membrane (By similarity). Regulates retrograde transport of proteins such as phosphorylated form of BACE1 from endosomes to the trans-Golgi network . .

AccessionsQ9UJY5
ENST00000411501.5
ENST00000449944.5
B0QYS2
ENST00000405147.7
B0QYR9
ENST00000439161.5
ENST00000343632.9 [Q9UJY5-1]
ENST00000431745.5
ENST00000413251.5
ENST00000326597.6
ENST00000381756.9 [Q9UJY5-6]
ENST00000429218.5
B0QYS0
ENST00000423024.1
ENST00000325180.12 [Q9UJY5-4]
ENST00000406772.5 [Q9UJY5-3]
B0QYS5
B0QYS3
B0QYR5
ENST00000447515.5
B0QYS1
B0QYR8
ENST00000453208.5
B0QYR6