GCSH report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006546Biological processglycine catabolic process
GO_0009249Biological processprotein lipoylation
GO_0019464Biological processglycine decarboxylation via glycine cleavage system
GO_0005960Cellular componentglycine cleavage complex
GO_0005759Cellular componentmitochondrial matrix
GO_0005737Cellular componentcytoplasm
GO_0005739Cellular componentmitochondrion
GO_0004047Molecular functionaminomethyltransferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameGCSH
Protein nameGlycine cleavage system protein H
Glycine cleavage system H protein, mitochondrial (Lipoic acid-containing protein)
Glycine cleavage system H protein
SynonymshCG_1980047
DescriptionFUNCTION: The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST). Has a pivotal role in the lipoylation of enzymes involved in cellular energetics such as the mitochondrial dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex (DLAT), and the mitochondrial dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex (DLST) . .

FUNCTION: The H protein shuttles the methylamine group of glycine from the P protein to the T protein. .

FUNCTION: The H protein shuttles the methylamine group of glycine from the P protein to the T protein. .

FUNCTION: The H protein shuttles the methylamine group of glycine from the P protein to the T protein. .

FUNCTION: The H protein shuttles the methylamine group of glycine from the P protein to the T protein. .

AccessionsENST00000639689.1
ENST00000561801.2
H3BQ30
P23434
ENST00000709349.1
ENST00000640150.1
A0A1W2PQX3
ENST00000315467.9
ENST00000566566.2
A0A1W2PNX3
H3BPF0
Q53XL7
Q6IAT2
H3BNV1
ENST00000564386.6
ENST00000564477.1
A0A1W2PQV2
ENST00000639169.1
ENST00000569885.6
H3BUH9
H3BUG8