GCM1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of GCM1 at tissue level.

III. Associated gene sets

GO_0006366Biological processtranscription by RNA polymerase II
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0060143Biological processpositive regulation of syncytium formation by plasma membrane fusion
GO_0000768Biological processsyncytium formation by plasma membrane fusion
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0042063Biological processgliogenesis
GO_0006355Biological processregulation of DNA-templated transcription
GO_0060670Biological processbranching involved in labyrinthine layer morphogenesis
GO_0009653Biological processanatomical structure morphogenesis
GO_0060018Biological processastrocyte fate commitment
GO_0060706Biological processcell differentiation involved in embryonic placenta development
GO_0060800Biological processregulation of cell differentiation involved in embryonic placenta development
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0000785Cellular componentchromatin
GO_0005667Cellular componenttranscription regulator complex
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0008270Molecular functionzinc ion binding
GO_0005515Molecular functionprotein binding
GO_0042826Molecular functionhistone deacetylase binding

IV. Literature review

[source]
Gene nameGCM1
Protein nameChorion-specific transcription factor GCMa (hGCMa) (GCM motif protein 1) (Glial cells missing homolog 1)
SynonymsGCMA
DescriptionFUNCTION: Transcription factor involved in the control of expression of placental growth factor (PGF) and other placenta-specific genes . Binds to the trophoblast-specific element 2 (TSE2) of the aromatase gene enhancer . Binds to the SYDE1 promoter . Has a central role in mediating the differentiation of trophoblast cells along both the villous and extravillous pathways in placental development . .

AccessionsENST00000259803.8
Q9NP62