GAR1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of GAR1 at tissue level.

III. Associated gene sets

GO_0000454Biological processsnoRNA guided rRNA pseudouridine synthesis
GO_0007004Biological processtelomere maintenance via telomerase
GO_0001650Cellular componentfibrillar center
GO_0000781Cellular componentchromosome, telomeric region
GO_0005654Cellular componentnucleoplasm
GO_0031429Cellular componentbox H/ACA snoRNP complex
GO_0072589Cellular componentbox H/ACA scaRNP complex
GO_0090661Cellular componentbox H/ACA telomerase RNP complex
GO_0005697Cellular componenttelomerase holoenzyme complex
GO_0070034Molecular functiontelomerase RNA binding
GO_0005515Molecular functionprotein binding
GO_0034513Molecular functionbox H/ACA snoRNA binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameGAR1
Protein nameH/ACA ribonucleoprotein complex subunit 1 (Nucleolar protein family A member 1) (snoRNP protein GAR1)
SynonymsNOLA1
DescriptionFUNCTION: Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme. .

AccessionsENST00000226796.7 [Q9NY12-1]
ENST00000394631.7 [Q9NY12-1]
Q9NY12