GALNT11 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016266Biological processO-glycan processing
GO_0007220Biological processNotch receptor processing
GO_0060271Biological processcilium assembly
GO_0008593Biological processregulation of Notch signaling pathway
GO_0061314Biological processNotch signaling involved in heart development
GO_0007368Biological processdetermination of left/right symmetry
GO_0018243Biological processprotein O-linked glycosylation via threonine
GO_0006493Biological processprotein O-linked glycosylation
GO_0000139Cellular componentGolgi membrane
GO_0005794Cellular componentGolgi apparatus
GO_0005112Molecular functionNotch binding
GO_0004653Molecular functionpolypeptide N-acetylgalactosaminyltransferase activity
GO_0030246Molecular functioncarbohydrate binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameGALNT11
Protein namePolypeptide N-acetylgalactosaminyltransferase 11
Polypeptide N-acetylgalactosaminyltransferase 11 (cDNA FLJ57736, highly similar to PolypeptideN-acetylgalactosaminyltransferase 11)
Polypeptide N-acetylgalactosaminyltransferase 11 (EC 2.4.1.41) (Polypeptide GalNAc transferase 11) (GalNAc-T11) (pp-GaNTase 11) (Protein-UDP acetylgalactosaminyltransferase 11) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 11)
Alternative protein GALNT11
Polypeptide N-acetylgalactosaminyltransferase (EC 2.4.1.-) (Protein-UDP acetylgalactosaminyltransferase)
SynonymshCG_1990637
tcag7.1057
DescriptionFUNCTION: Polypeptide N-acetylgalactosaminyltransferase that catalyzes the initiation of protein O-linked glycosylation and is involved in left/right asymmetry by mediating O-glycosylation of NOTCH1. O-glycosylation of NOTCH1 promotes activation of NOTCH1, modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO). Polypeptide N-acetylgalactosaminyltransferases catalyze the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Displays the same enzyme activity toward MUC1, MUC4, and EA2 than GALNT1. Not involved in glycosylation of erythropoietin (EPO). .

AccessionsENST00000447778.5
ENST00000431668.1
ENST00000446096.5
ENST00000423337.5
ENST00000430044.7 [Q8NCW6-1]
ENST00000431940.1
C9K0N9
ENST00000447796.1
Q8NCW6
C9J111
A0A090N7X6
C9JPR8
ENST00000434507.5 [Q8NCW6-1]
C9J8A7
ENST00000422997.6 [Q8NCW6-2]
H7BZL5
B7Z3L9
C9JMT8
ENST00000415421.5 [Q8NCW6-2]
ENST00000419245.5
L8EB40