G6PD | OmnibusX

Name	Number of supported studies	Average coverage
natural killer cell	22 studies	26% ± 8%	Explore
classical monocyte	13 studies	29% ± 11%	Explore
CD16-positive, CD56-dim natural killer cell, human	12 studies	29% ± 8%	Explore
non-classical monocyte	11 studies	24% ± 9%	Explore
CD16-negative, CD56-bright natural killer cell, human	10 studies	30% ± 8%	Explore
CD8-positive, alpha-beta T cell	8 studies	18% ± 3%	Explore
mature NK T cell	7 studies	25% ± 7%	Explore
gamma-delta T cell	6 studies	23% ± 7%	Explore
macrophage	5 studies	22% ± 7%	Explore
conventional dendritic cell	4 studies	32% ± 10%	Explore
hematopoietic precursor cell	4 studies	22% ± 3%	Explore
myeloid cell	4 studies	32% ± 11%	Explore
epithelial cell	4 studies	24% ± 5%	Explore
monocyte	4 studies	21% ± 5%	Explore
platelet	3 studies	22% ± 9%	Explore
effector CD8-positive, alpha-beta T cell	3 studies	25% ± 2%	Explore
megakaryocyte	3 studies	23% ± 8%	Explore
basal cell	3 studies	25% ± 10%	Explore
hematopoietic stem cell	3 studies	20% ± 2%	Explore
double negative thymocyte	3 studies	21% ± 4%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	9 studies	20% ± 3%	Explore
lung	3 studies	24% ± 7%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
thymus	100%	5250.29	653 / 653	100%	82.05	605 / 605
ovary	100%	3474.21	180 / 180	100%	57.28	428 / 430
esophagus	100%	3314.64	1438 / 1445	100%	191.20	183 / 183
uterus	100%	3054.77	170 / 170	99%	95.83	456 / 459
skin	100%	4009.95	1807 / 1809	99%	89.75	469 / 472
adrenal gland	100%	6148.26	258 / 258	99%	77.15	227 / 230
breast	100%	3094.59	459 / 459	99%	71.87	1102 / 1118
lung	99%	3816.78	575 / 578	99%	174.79	1141 / 1155
intestine	99%	1617.73	956 / 966	99%	54.76	523 / 527
prostate	100%	2290.46	244 / 245	99%	36.37	495 / 502
bladder	100%	5229.29	21 / 21	97%	102.38	491 / 504
brain	97%	2015.69	2558 / 2642	100%	42.26	703 / 705
kidney	100%	2070.66	89 / 89	96%	47.66	866 / 901
stomach	95%	1862.82	342 / 359	99%	60.82	282 / 286
pancreas	51%	526.45	166 / 328	97%	43.48	173 / 178
adipose	100%	3704.16	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	49.16	80 / 80
lymph node	0%	0	0 / 0	100%	80.12	29 / 29
spleen	100%	4372.73	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	86.35	45 / 45
ureter	0%	0	0 / 0	100%	22.06	1 / 1
peripheral blood	100%	9769.07	928 / 929	0%	0	0 / 0
blood vessel	100%	3866.28	1333 / 1335	0%	0	0 / 0
heart	66%	1095.99	566 / 861	0%	0	0 / 0
liver	8%	94.94	18 / 226	56%	38.54	229 / 406
muscle	9%	87.00	71 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006739	Biological process	NADP metabolic process
GO_0006098	Biological process	pentose-phosphate shunt
GO_0010041	Biological process	response to iron(III) ion
GO_0006740	Biological process	NADPH regeneration
GO_0043249	Biological process	erythrocyte maturation
GO_0009051	Biological process	pentose-phosphate shunt, oxidative branch
GO_0014070	Biological process	response to organic cyclic compound
GO_2000378	Biological process	negative regulation of reactive oxygen species metabolic process
GO_0045471	Biological process	response to ethanol
GO_0043523	Biological process	regulation of neuron apoptotic process
GO_0019322	Biological process	pentose biosynthetic process
GO_0061052	Biological process	negative regulation of cell growth involved in cardiac muscle cell development
GO_0034599	Biological process	cellular response to oxidative stress
GO_1904879	Biological process	positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
GO_0021762	Biological process	substantia nigra development
GO_0010734	Biological process	negative regulation of protein glutathionylation
GO_0032094	Biological process	response to food
GO_0051156	Biological process	glucose 6-phosphate metabolic process
GO_0006629	Biological process	lipid metabolic process
GO_0006695	Biological process	cholesterol biosynthetic process
GO_0006006	Biological process	glucose metabolic process
GO_0046390	Biological process	ribose phosphate biosynthetic process
GO_0006749	Biological process	glutathione metabolic process
GO_0034451	Cellular component	centriolar satellite
GO_0016020	Cellular component	membrane
GO_0009898	Cellular component	cytoplasmic side of plasma membrane
GO_0070062	Cellular component	extracellular exosome
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0043231	Cellular component	intracellular membrane-bounded organelle
GO_0042803	Molecular function	protein homodimerization activity
GO_0042802	Molecular function	identical protein binding
GO_0004345	Molecular function	glucose-6-phosphate dehydrogenase activity
GO_0050661	Molecular function	NADP binding
GO_0005536	Molecular function	D-glucose binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	G6PD
Protein name	glucose-6-phosphate dehydrogenase (NADP(+)) (EC 1.1.1.49) Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49) Glucose-6-phosphate dehydrogenase Glucose-6-phosphate 1-dehydrogenase (G6PD) (EC 1.1.1.49)
Synonyms
Description	FUNCTION: Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis. . FUNCTION: Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. . FUNCTION: Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. . FUNCTION: Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. . FUNCTION: Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. . FUNCTION: Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. . FUNCTION: Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. . FUNCTION: Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. . FUNCTION: Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. . FUNCTION: Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. . FUNCTION: Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. . FUNCTION: Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. .
Accessions	A0A2H4QGB2 Q2VF42 ENST00000696429.1 [P11413-1] A0A8Q3SJB9 ENST00000696426.1 Q0PHS2 A0A8Q3SIN6 ENST00000696427.1 Q2Q9B7 A0A8Q3WL83 ENST00000696422.1 ENST00000393562.10 [P11413-1] E7EUI8 ENST00000393564.7 [P11413-1] A7IZZ3 A0A8Q3WL90 ENST00000696428.1 Q0PHS5 ENST00000439227.6 ENST00000696431.1 ENST00000696424.1 ENST00000696421.1 Q2Q9H2 A0A8Q3WL93 A0A8Q3WLB9 ENST00000696420.1 Q0PHS4 ENST00000696430.1 [P11413-1] A0A2H4QGB8 Q0PHS3 A0A8Q3WL95 ENST00000696425.1 ENST00000369620.6 [P11413-2] A2IBT6 A0A6G9IW12 A0A8Q3SIS5 A0A8Q3WLT0 ENST00000696423.1 E9PD92 A0A8Q3WL80 ENST00000433845.1 A0A2H4QGB6 B6ZHS6 E7EM57 Q0PHS1 P11413 ENST00000440967.5 Q0PHS6 A0A8G1M3Q3

G6PD report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review