FOXA3 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of FOXA3 at tissue level.

III. Associated gene sets

GO_0006325Biological processchromatin organization
GO_0006366Biological processtranscription by RNA polymerase II
GO_0007283Biological processspermatogenesis
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0009267Biological processcellular response to starvation
GO_0001678Biological processintracellular glucose homeostasis
GO_0061484Biological processhematopoietic stem cell homeostasis
GO_0030154Biological processcell differentiation
GO_0009653Biological processanatomical structure morphogenesis
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005654Cellular componentnucleoplasm
GO_0015629Cellular componentactin cytoskeleton
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0019904Molecular functionprotein domain specific binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0000976Molecular functiontranscription cis-regulatory region binding
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameFOXA3
Protein nameHepatocyte nuclear factor 3-gamma (HNF-3-gamma) (HNF-3G) (Fork head-related protein FKH H3) (Forkhead box protein A3) (Transcription factor 3G) (TCF-3G)
Forkhead box A3
SynonymsHNF3G
TCF3G
DescriptionFUNCTION: Transcription factor that is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites (By similarity). Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; binds to and activates transcription from the G6PC1 promoter. Binds to the CYP3A4 promoter and activates its transcription in cooperation with CEBPA. Binds to the CYP3A7 promoter together with members of the CTF/NF-I family. Involved in regulation of neuronal-specific transcription. May be involved in regulation of spermatogenesis. .

AccessionsM0QZW5
ENST00000302177.3
ENST00000594297.1
P55318