FAF2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006986Biological processresponse to unfolded protein
GO_0030970Biological processretrograde protein transport, ER to cytosol
GO_0035617Biological processstress granule disassembly
GO_0034389Biological processlipid droplet organization
GO_0036503Biological processERAD pathway
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0035578Cellular componentazurophil granule lumen
GO_0005783Cellular componentendoplasmic reticulum
GO_0005576Cellular componentextracellular region
GO_0005811Cellular componentlipid droplet
GO_0034098Cellular componentVCP-NPL4-UFD1 AAA ATPase complex
GO_0055102Molecular functionlipase inhibitor activity
GO_0043130Molecular functionubiquitin binding
GO_0030674Molecular functionprotein-macromolecule adaptor activity
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0005515Molecular functionprotein binding
GO_0035473Molecular functionlipase binding

IV. Literature review

[source]
Gene nameFAF2
Protein nameFas associated factor family member 2
FAS-associated factor 2 (UBX domain-containing protein 3B) (UBX domain-containing protein 8)
SynonymsUBXD8
KIAA0887
UBXN3B
ETEA
DescriptionFUNCTION: Plays an important role in endoplasmic reticulum-associated degradation (ERAD) that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins . By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway . Involved in inhibition of lipid droplet degradation by binding to phospholipase PNPL2 and inhibiting its activity by promoting dissociation of PNPL2 from its endogenous activator, ABHD5 which inhibits the rate of triacylglycerol hydrolysis . Involved in stress granule disassembly: associates with ubiquitinated G3BP1 in response to heat shock, thereby promoting interaction between ubiquitinated G3BP1 and VCP, followed by G3BP1 extraction from stress granules and stress granule disassembly . .

AccessionsQ96CS3
ENST00000261942.7
ENST00000510730.5
D6RBG6