EXOSC9 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of EXOSC9 at tissue level.

III. Associated gene sets

GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0071038Biological processTRAMP-dependent tRNA surveillance pathway
GO_0006402Biological processmRNA catabolic process
GO_0071035Biological processnuclear polyadenylation-dependent rRNA catabolic process
GO_0030307Biological processpositive regulation of cell growth
GO_0006396Biological processRNA processing
GO_0034475Biological processU4 snRNA 3'-end processing
GO_0006401Biological processRNA catabolic process
GO_0034473Biological processU1 snRNA 3'-end processing
GO_0006955Biological processimmune response
GO_0034476Biological processU5 snRNA 3'-end processing
GO_0071028Biological processnuclear mRNA surveillance
GO_0000288Biological processnuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO_0000956Biological processnuclear-transcribed mRNA catabolic process
GO_0006364Biological processrRNA processing
GO_0000467Biological processexonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO_0005730Cellular componentnucleolus
GO_0000178Cellular componentexosome (RNase complex)
GO_0000228Cellular componentnuclear chromosome
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0000177Cellular componentcytoplasmic exosome (RNase complex)
GO_0101019Cellular componentnucleolar exosome (RNase complex)
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0000176Cellular componentnuclear exosome (RNase complex)
GO_0005634Cellular componentnucleus
GO_0004532Molecular functionRNA exonuclease activity
GO_0061629Molecular functionRNA polymerase II-specific DNA-binding transcription factor binding
GO_0035925Molecular functionmRNA 3'-UTR AU-rich region binding
GO_0003723Molecular functionRNA binding
GO_0000175Molecular function3'-5'-RNA exonuclease activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameEXOSC9
Protein nameExosome complex component RRP45 (Exosome component 9)
Exosome complex component RRP45 (Autoantigen PM/Scl 1) (Exosome component 9) (P75 polymyositis-scleroderma overlap syndrome-associated autoantigen) (Polymyositis/scleroderma autoantigen 1) (Polymyositis/scleroderma autoantigen 75 kDa) (PM/Scl-75)
Exosome component 9
SynonymshCG_38830
PMSCL1
DescriptionFUNCTION: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC9 binds to ARE-containing RNAs. .

AccessionsENST00000512454.5
ENST00000513654.5
ENST00000379663.7 [Q06265-2]
ENST00000511132.1
D6RIY6
A5PLM5
Q06265
D6R905
D6RA17
D6RAP4
ENST00000243498.10 [Q06265-1]
ENST00000511454.5
H0Y9L5
ENST00000509800.5