Name | Number of supported studies | Average coverage | |
---|---|---|---|
renal alpha-intercalated cell | 6 studies | 42% ± 12% | |
basal cell | 6 studies | 29% ± 14% | |
epithelial cell | 5 studies | 34% ± 10% | |
endothelial cell | 4 studies | 20% ± 6% | |
natural killer cell | 4 studies | 18% ± 3% | |
fibroblast | 4 studies | 22% ± 5% | |
CD16-negative, CD56-bright natural killer cell, human | 3 studies | 20% ± 3% | |
CD4-positive, alpha-beta T cell | 3 studies | 19% ± 2% | |
hematopoietic precursor cell | 3 studies | 20% ± 5% | |
ciliated cell | 3 studies | 26% ± 1% | |
erythroblast | 3 studies | 29% ± 9% | |
GABAergic neuron | 3 studies | 35% ± 11% | |
glutamatergic neuron | 3 studies | 39% ± 15% | |
dendritic cell | 3 studies | 30% ± 4% | |
astrocyte | 3 studies | 19% ± 2% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
bladder | 100% | 1334.05 | 21 / 21 | 100% | 24.75 | 504 / 504 |
ovary | 100% | 1410.79 | 180 / 180 | 100% | 12.39 | 430 / 430 |
prostate | 100% | 1461.42 | 245 / 245 | 100% | 22.35 | 502 / 502 |
skin | 100% | 2777.32 | 1809 / 1809 | 100% | 17.13 | 472 / 472 |
thymus | 100% | 1489.07 | 653 / 653 | 100% | 24.23 | 605 / 605 |
uterus | 100% | 1443.55 | 170 / 170 | 100% | 23.93 | 459 / 459 |
intestine | 100% | 1089.33 | 966 / 966 | 100% | 21.92 | 525 / 527 |
adrenal gland | 100% | 3014.55 | 258 / 258 | 100% | 19.38 | 229 / 230 |
liver | 100% | 761.76 | 226 / 226 | 100% | 11.56 | 404 / 406 |
breast | 100% | 1283.46 | 459 / 459 | 99% | 16.75 | 1112 / 1118 |
esophagus | 100% | 1264.64 | 1444 / 1445 | 99% | 11.15 | 182 / 183 |
brain | 99% | 987.08 | 2616 / 2642 | 100% | 18.00 | 705 / 705 |
lung | 99% | 1159.17 | 574 / 578 | 100% | 17.89 | 1151 / 1155 |
kidney | 100% | 1622.42 | 89 / 89 | 99% | 13.09 | 889 / 901 |
stomach | 100% | 1068.99 | 359 / 359 | 99% | 16.84 | 282 / 286 |
pancreas | 99% | 630.71 | 325 / 328 | 99% | 18.63 | 177 / 178 |
eye | 0% | 0 | 0 / 0 | 100% | 14.32 | 80 / 80 |
lymph node | 0% | 0 | 0 / 0 | 100% | 33.21 | 29 / 29 |
spleen | 100% | 1303.24 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 20.87 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 31.99 | 1 / 1 |
adipose | 100% | 1190.43 | 1203 / 1204 | 0% | 0 | 0 / 0 |
muscle | 100% | 1638.76 | 802 / 803 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 1123.11 | 1333 / 1335 | 0% | 0 | 0 / 0 |
heart | 97% | 1053.81 | 833 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 73% | 1000.51 | 682 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0071038 | Biological process | TRAMP-dependent tRNA surveillance pathway |
GO_0071035 | Biological process | nuclear polyadenylation-dependent rRNA catabolic process |
GO_0006396 | Biological process | RNA processing |
GO_0034475 | Biological process | U4 snRNA 3'-end processing |
GO_0006401 | Biological process | RNA catabolic process |
GO_0034473 | Biological process | U1 snRNA 3'-end processing |
GO_0034476 | Biological process | U5 snRNA 3'-end processing |
GO_0071028 | Biological process | nuclear mRNA surveillance |
GO_0000288 | Biological process | nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay |
GO_0000956 | Biological process | nuclear-transcribed mRNA catabolic process |
GO_0006364 | Biological process | rRNA processing |
GO_0000467 | Biological process | exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
GO_0005730 | Cellular component | nucleolus |
GO_0000178 | Cellular component | exosome (RNase complex) |
GO_0005654 | Cellular component | nucleoplasm |
GO_0000177 | Cellular component | cytoplasmic exosome (RNase complex) |
GO_0101019 | Cellular component | nucleolar exosome (RNase complex) |
GO_0005829 | Cellular component | cytosol |
GO_0000176 | Cellular component | nuclear exosome (RNase complex) |
GO_0005634 | Cellular component | nucleus |
GO_0004532 | Molecular function | RNA exonuclease activity |
GO_0035925 | Molecular function | mRNA 3'-UTR AU-rich region binding |
GO_0003723 | Molecular function | RNA binding |
GO_0000175 | Molecular function | 3'-5'-RNA exonuclease activity |
GO_0005515 | Molecular function | protein binding |
Gene name | EXOSC7 |
Protein name | Exosome complex component RRP42 (Exosome component 7) (Ribosomal RNA-processing protein 42) (p8) |
Synonyms | KIAA0116 RRP42 |
Description | FUNCTION: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. |
Accessions | Q15024 ENST00000265564.8 |