EXOSC1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006401Biological processRNA catabolic process
GO_0006364Biological processrRNA processing
GO_0006396Biological processRNA processing
GO_0000177Cellular componentcytoplasmic exosome (RNase complex)
GO_0005730Cellular componentnucleolus
GO_0101019Cellular componentnucleolar exosome (RNase complex)
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0000178Cellular componentexosome (RNase complex)
GO_0000176Cellular componentnuclear exosome (RNase complex)
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0004532Molecular functionRNA exonuclease activity
GO_0005515Molecular functionprotein binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameEXOSC1
Protein nameExosome component 1
Exosome complex component CSL4 (Exosome component 1)
SynonymsCGI-108
CSL4
DescriptionFUNCTION: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC1 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC6 and EXOSC8.

AccessionsB1AMU7
R4GMQ7
ENST00000485122.6
ENST00000370885.8
ENST00000370902.8
Q9Y3B2
B1AMU4
ENST00000477692.6
ENST00000370886.9
R4GNH9
B1AMU3
ENST00000370884.5