Name | Number of supported studies | Average coverage | |
---|---|---|---|
regulatory T cell | 9 studies | 18% ± 3% | |
CD4-positive, alpha-beta T cell | 5 studies | 18% ± 2% | |
epithelial cell | 5 studies | 29% ± 10% | |
ciliated cell | 5 studies | 25% ± 4% | |
classical monocyte | 4 studies | 24% ± 7% | |
effector memory CD8-positive, alpha-beta T cell | 4 studies | 17% ± 2% | |
non-classical monocyte | 4 studies | 28% ± 9% | |
natural killer cell | 4 studies | 20% ± 3% | |
endothelial cell | 4 studies | 21% ± 7% | |
plasmacytoid dendritic cell | 4 studies | 20% ± 5% | |
CD16-positive, CD56-dim natural killer cell, human | 3 studies | 16% ± 1% | |
conventional dendritic cell | 3 studies | 32% ± 14% | |
hematopoietic precursor cell | 3 studies | 22% ± 3% | |
plasma cell | 3 studies | 28% ± 13% | |
astrocyte | 3 studies | 19% ± 2% | |
glutamatergic neuron | 3 studies | 39% ± 16% | |
CD8-positive, alpha-beta T cell | 3 studies | 21% ± 4% | |
dendritic cell | 3 studies | 34% ± 9% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
bladder | 100% | 1007.57 | 21 / 21 | 100% | 24.13 | 504 / 504 |
esophagus | 100% | 917.22 | 1445 / 1445 | 100% | 18.06 | 183 / 183 |
lung | 100% | 860.42 | 578 / 578 | 100% | 22.43 | 1155 / 1155 |
ovary | 100% | 912.67 | 180 / 180 | 100% | 24.07 | 430 / 430 |
pancreas | 100% | 808.88 | 328 / 328 | 100% | 21.04 | 178 / 178 |
prostate | 100% | 1033.59 | 245 / 245 | 100% | 18.43 | 502 / 502 |
skin | 100% | 996.31 | 1809 / 1809 | 100% | 19.83 | 472 / 472 |
stomach | 100% | 925.72 | 359 / 359 | 100% | 20.40 | 286 / 286 |
thymus | 100% | 960.06 | 653 / 653 | 100% | 25.89 | 605 / 605 |
uterus | 100% | 993.14 | 170 / 170 | 100% | 25.60 | 459 / 459 |
breast | 100% | 918.97 | 459 / 459 | 100% | 23.49 | 1117 / 1118 |
brain | 100% | 736.69 | 2639 / 2642 | 100% | 13.93 | 705 / 705 |
intestine | 100% | 935.11 | 966 / 966 | 100% | 21.43 | 526 / 527 |
adrenal gland | 100% | 943.67 | 258 / 258 | 100% | 19.83 | 229 / 230 |
liver | 100% | 549.45 | 226 / 226 | 100% | 15.24 | 404 / 406 |
kidney | 100% | 850.10 | 89 / 89 | 99% | 13.91 | 889 / 901 |
adipose | 100% | 853.10 | 1204 / 1204 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 100% | 19.86 | 80 / 80 |
lymph node | 0% | 0 | 0 / 0 | 100% | 37.87 | 29 / 29 |
spleen | 100% | 1190.17 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 20.03 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 13.57 | 1 / 1 |
blood vessel | 100% | 885.99 | 1334 / 1335 | 0% | 0 | 0 / 0 |
muscle | 100% | 646.49 | 801 / 803 | 0% | 0 | 0 / 0 |
heart | 99% | 561.40 | 851 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 99% | 874.92 | 918 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0006401 | Biological process | RNA catabolic process |
GO_0006364 | Biological process | rRNA processing |
GO_0006396 | Biological process | RNA processing |
GO_0000177 | Cellular component | cytoplasmic exosome (RNase complex) |
GO_0005730 | Cellular component | nucleolus |
GO_0101019 | Cellular component | nucleolar exosome (RNase complex) |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005829 | Cellular component | cytosol |
GO_0000178 | Cellular component | exosome (RNase complex) |
GO_0000176 | Cellular component | nuclear exosome (RNase complex) |
GO_0005737 | Cellular component | cytoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0004532 | Molecular function | RNA exonuclease activity |
GO_0005515 | Molecular function | protein binding |
GO_0003723 | Molecular function | RNA binding |
Gene name | EXOSC1 |
Protein name | Exosome component 1 Exosome complex component CSL4 (Exosome component 1) |
Synonyms | CGI-108 CSL4 |
Description | FUNCTION: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC1 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC6 and EXOSC8. |
Accessions | B1AMU7 R4GMQ7 ENST00000485122.6 ENST00000370885.8 ENST00000370902.8 Q9Y3B2 B1AMU4 ENST00000477692.6 ENST00000370886.9 R4GNH9 B1AMU3 ENST00000370884.5 |