I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| epithelial cell | 3 studies | 18% ± 2% | |
| GABAergic neuron | 3 studies | 28% ± 6% | |
| glutamatergic neuron | 3 studies | 38% ± 8% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| epithelial cell | 3 studies | 18% ± 2% | |
| GABAergic neuron | 3 studies | 28% ± 6% | |
| glutamatergic neuron | 3 studies | 38% ± 8% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 4 studies | 26% ± 6% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| breast | 100% | 474.85 | 459 / 459 | 100% | 6.60 | 1114 / 1118 |
| brain | 100% | 466.54 | 2636 / 2642 | 100% | 6.59 | 704 / 705 |
| esophagus | 99% | 486.46 | 1434 / 1445 | 100% | 4.15 | 183 / 183 |
| prostate | 100% | 485.28 | 245 / 245 | 99% | 4.71 | 495 / 502 |
| ovary | 100% | 548.12 | 180 / 180 | 98% | 3.70 | 422 / 430 |
| thymus | 100% | 477.64 | 653 / 653 | 98% | 3.58 | 593 / 605 |
| lung | 98% | 400.37 | 567 / 578 | 99% | 4.17 | 1147 / 1155 |
| adrenal gland | 100% | 877.14 | 257 / 258 | 97% | 4.35 | 224 / 230 |
| stomach | 99% | 404.80 | 357 / 359 | 97% | 3.02 | 277 / 286 |
| kidney | 100% | 280.93 | 89 / 89 | 96% | 3.71 | 864 / 901 |
| uterus | 100% | 617.58 | 170 / 170 | 96% | 3.61 | 440 / 459 |
| pancreas | 99% | 307.58 | 325 / 328 | 97% | 2.83 | 172 / 178 |
| skin | 100% | 566.74 | 1804 / 1809 | 95% | 4.48 | 450 / 472 |
| intestine | 100% | 484.58 | 964 / 966 | 95% | 2.63 | 501 / 527 |
| bladder | 100% | 643.24 | 21 / 21 | 94% | 2.99 | 476 / 504 |
| liver | 98% | 297.53 | 221 / 226 | 74% | 1.61 | 301 / 406 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 3.94 | 29 / 29 |
| spleen | 100% | 539.77 | 241 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 1.38 | 1 / 1 |
| muscle | 100% | 609.32 | 802 / 803 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 486.59 | 1333 / 1335 | 0% | 0 | 0 / 0 |
| adipose | 100% | 473.88 | 1201 / 1204 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 98% | 3.86 | 44 / 45 |
| heart | 97% | 374.26 | 836 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 78% | 2.05 | 62 / 80 |
| peripheral blood | 47% | 231.73 | 440 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0006303 | Biological process | double-strand break repair via nonhomologous end joining |
| GO_0006281 | Biological process | DNA repair |
| GO_1905768 | Biological process | negative regulation of double-stranded telomeric DNA binding |
| GO_0051974 | Biological process | negative regulation of telomerase activity |
| GO_0034644 | Biological process | cellular response to UV |
| GO_0009650 | Biological process | UV protection |
| GO_0032205 | Biological process | negative regulation of telomere maintenance |
| GO_0006289 | Biological process | nucleotide-excision repair |
| GO_0009411 | Biological process | response to UV |
| GO_1904357 | Biological process | negative regulation of telomere maintenance via telomere lengthening |
| GO_0000724 | Biological process | double-strand break repair via homologous recombination |
| GO_0010506 | Biological process | regulation of autophagy |
| GO_1905765 | Biological process | negative regulation of protection from non-homologous end joining at telomere |
| GO_0000723 | Biological process | telomere maintenance |
| GO_0000712 | Biological process | resolution of meiotic recombination intermediates |
| GO_0061819 | Biological process | telomeric DNA-containing double minutes formation |
| GO_1901255 | Biological process | nucleotide-excision repair involved in interstrand cross-link repair |
| GO_0000110 | Cellular component | nucleotide-excision repair factor 1 complex |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0070522 | Cellular component | ERCC4-ERCC1 complex |
| GO_0000109 | Cellular component | nucleotide-excision repair complex |
| GO_0000781 | Cellular component | chromosome, telomeric region |
| GO_0005634 | Cellular component | nucleus |
| GO_0003677 | Molecular function | DNA binding |
| GO_1990841 | Molecular function | promoter-specific chromatin binding |
| GO_0003697 | Molecular function | single-stranded DNA binding |
| GO_0001094 | Molecular function | TFIID-class transcription factor complex binding |
| GO_0042802 | Molecular function | identical protein binding |
| GO_0010521 | Molecular function | telomerase inhibitor activity |
| GO_0004520 | Molecular function | DNA endonuclease activity |
| GO_1990599 | Molecular function | 3' overhang single-stranded DNA endodeoxyribonuclease activity |
| GO_0000014 | Molecular function | single-stranded DNA endodeoxyribonuclease activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0003684 | Molecular function | damaged DNA binding |
| Gene name | ERCC4 |
| Protein name | DNA repair endonuclease XPF ERCC excision repair 4, endonuclease catalytic subunit DNA repair endonuclease XPF (Excision repair cross-complementing rodent repair deficiency, complementation group 4, isoform CRA_a) ERCC4 protein DNA repair endonuclease XPF (EC 3.1.-.-) (DNA excision repair protein ERCC-4) (DNA repair protein complementing XP-F cells) (Xeroderma pigmentosum group F-complementing protein) |
| Synonyms | XPF hCG_37239 ERCC11 |
| Description | FUNCTION: Catalytic component of a structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair, and which is essential for nucleotide excision repair (NER) and interstrand cross-link (ICL) repair. . |
| Accessions | ENST00000311895.8 [Q92889-1] A0PJA9 I3L4K0 ENST00000682617.1 I3NI48 Q92889 ENST00000574194.1 ENST00000462862.1 A0A1W1GST9 A0A1W1GSP5 A0A1W1GSL6 A0A804HIY2 A0A804HKF9 ENST00000575156.5 [Q92889-2] ENST00000683962.1 A0A1W1GSK9 ENST00000682826.1 A0A804HI16 |
