EPHA3 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
glutamatergic neuron	11 studies	39% ± 19%	Explore
pericyte	7 studies	30% ± 8%	Explore
GABAergic neuron	7 studies	32% ± 12%	Explore
endothelial cell	6 studies	34% ± 14%	Explore
interneuron	6 studies	38% ± 13%	Explore
smooth muscle cell	6 studies	29% ± 9%	Explore
fibroblast	5 studies	38% ± 12%	Explore
neuron	4 studies	21% ± 4%	Explore
astrocyte	4 studies	43% ± 20%	Explore
retina horizontal cell	4 studies	53% ± 14%	Explore
retinal rod cell	4 studies	45% ± 16%	Explore
GABAergic interneuron	3 studies	24% ± 7%	Explore
microglial cell	3 studies	51% ± 15%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	12 studies	30% ± 16%	Explore
eye	4 studies	29% ± 11%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
prostate	100%	3600.08	245 / 245	96%	21.36	483 / 502
thymus	100%	2936.58	651 / 653	71%	4.80	431 / 605
bladder	100%	1791.14	21 / 21	39%	2.11	197 / 504
breast	94%	688.03	431 / 459	44%	4.52	487 / 1118
pancreas	48%	183.60	158 / 328	88%	13.07	156 / 178
intestine	87%	779.78	841 / 966	35%	2.55	186 / 527
uterus	98%	1074.96	166 / 170	24%	3.18	109 / 459
esophagus	77%	789.13	1114 / 1445	42%	2.39	76 / 183
lung	72%	387.93	418 / 578	45%	3.72	519 / 1155
brain	45%	157.77	1192 / 2642	71%	5.23	498 / 705
stomach	63%	412.00	226 / 359	52%	5.10	150 / 286
adipose	100%	1042.39	1198 / 1204	0%	0	0 / 0
blood vessel	98%	1657.06	1314 / 1335	0%	0	0 / 0
heart	95%	950.67	822 / 861	0%	0	0 / 0
liver	53%	212.81	120 / 226	33%	2.45	134 / 406
ovary	74%	405.34	133 / 180	7%	0.40	28 / 430
kidney	21%	58.72	19 / 89	58%	6.92	523 / 901
skin	33%	128.87	595 / 1809	45%	7.07	213 / 472
adrenal gland	7%	19.51	18 / 258	44%	3.39	102 / 230
tonsil	0%	0	0 / 0	42%	2.78	19 / 45
lymph node	0%	0	0 / 0	21%	0.79	6 / 29
muscle	17%	57.73	139 / 803	0%	0	0 / 0
spleen	10%	27.27	23 / 241	0%	0	0 / 0
eye	0%	0	0 / 0	1%	0.04	1 / 80
peripheral blood	0%	0.49	1 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0071300	Biological process	cellular response to retinoic acid
GO_0048013	Biological process	ephrin receptor signaling pathway
GO_0010976	Biological process	positive regulation of neuron projection development
GO_0045806	Biological process	negative regulation of endocytosis
GO_0007155	Biological process	cell adhesion
GO_0097156	Biological process	fasciculation of motor neuron axon
GO_1903078	Biological process	positive regulation of protein localization to plasma membrane
GO_0018108	Biological process	peptidyl-tyrosine phosphorylation
GO_0043087	Biological process	regulation of GTPase activity
GO_0051893	Biological process	regulation of focal adhesion assembly
GO_0070507	Biological process	regulation of microtubule cytoskeleton organization
GO_0006468	Biological process	protein phosphorylation
GO_0010717	Biological process	regulation of epithelial to mesenchymal transition
GO_0097155	Biological process	fasciculation of sensory neuron axon
GO_0016477	Biological process	cell migration
GO_0032956	Biological process	regulation of actin cytoskeleton organization
GO_0007411	Biological process	axon guidance
GO_0005576	Cellular component	extracellular region
GO_0005886	Cellular component	plasma membrane
GO_0005769	Cellular component	early endosome
GO_0005654	Cellular component	nucleoplasm
GO_0030425	Cellular component	dendrite
GO_0015629	Cellular component	actin cytoskeleton
GO_0005829	Cellular component	cytosol
GO_0031965	Cellular component	nuclear membrane
GO_0005004	Molecular function	GPI-linked ephrin receptor activity
GO_0005003	Molecular function	ephrin receptor activity
GO_0005005	Molecular function	transmembrane-ephrin receptor activity
GO_0005524	Molecular function	ATP binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	EPHA3
Protein name	Ephrin type-A receptor 3 (EC 2.7.10.1) (EPH-like kinase 4) (EK4) (hEK4) (HEK) (Human embryo kinase) (Tyrosine-protein kinase TYRO4) (Tyrosine-protein kinase receptor ETK1) (Eph-like tyrosine kinase 1) receptor protein-tyrosine kinase (EC 2.7.10.1) Ephrin type-A receptor 3 variant (EC 2.7.10.1)
Synonyms	HEK hCG_33008 ETK ETK1 TYRO4
Description	FUNCTION: Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in cardiac cells migration and differentiation and regulates the formation of the atrioventricular canal and septum during development probably through activation by EFNA1. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development. .
Accessions	P29320 Q6P4R6 ENST00000494014.1 E2I6F6 A0A140VJJ0 C9JXA2 ENST00000452448.6 [P29320-2] ENST00000336596.7 [P29320-1]

EPHA3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review