EIF4EBP2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007613Biological processmemory
GO_0006412Biological processtranslation
GO_0031929Biological processTOR signaling
GO_0048167Biological processregulation of synaptic plasticity
GO_0008286Biological processinsulin receptor signaling pathway
GO_0050804Biological processmodulation of chemical synaptic transmission
GO_0035176Biological processsocial behavior
GO_0045947Biological processnegative regulation of translational initiation
GO_0098794Cellular componentpostsynapse
GO_0043232Cellular componentintracellular non-membrane-bounded organelle
GO_0071598Cellular componentneuronal ribonucleoprotein granule
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0030371Molecular functiontranslation repressor activity
GO_0005515Molecular functionprotein binding
GO_0008190Molecular functioneukaryotic initiation factor 4E binding

IV. Literature review

[source]
Gene nameEIF4EBP2
Protein nameeIF4EBP2 protein
Eukaryotic translation initiation factor 4E-binding protein 2 (4E-BP2) (eIF4E-binding protein 2)
Synonyms
DescriptionFUNCTION: Repressor of translation initiation involved in synaptic plasticity, learning and memory formation . Regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form of EIF4EBP2 competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation . EIF4EBP2 is enriched in brain and acts as a regulator of synapse activity and neuronal stem cell renewal via its ability to repress translation initiation (By similarity). Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways (By similarity). .

AccessionsQ13542
ENST00000373218.5
Q6FG68